Research in the Lynch lab focuses on second messenger signaling in nutrient sensing cells e.g. Pancreatic Beta-Cells) and the vasculature with emphasis on alterations in signaling that occur during development of Diabetes. We develotechnologies to modify and analyze beta-cell mass in order to evaluate the initiation of the pre-diabetic state, and efficacy of its treatment. Analysis of subcellular protein distributions, second messenger signaling, and ligand binding are performed using state of the art microscopy and analysis approaches which is a second area of expertise. For over 3 decades, the Lynch lab has worked on developing unique microscopic imaging and spectroscopy approaches to study cell and tissue function, as well as, screening assays for cell signaling and ligand binding.