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Research in the Lynch lab focuses on second messenger signaling in nutrient sensing cells (e.g., Pancreatic Beta-Cells) and the vasculature with emphasis on alterations in signaling that occur during development of Diabetes. We develop technologies to modify and analyze beta-cell mass in order to evaluate the initiation of the pre-diabetic state, and efficacy of its treatment. Analysis of subcellular protein distributions, second messenger signaling, and ligand binding are performed using state of the art microscopy and analysis approaches which is a second area of expertise. For over 3 decades, the Lynch lab has worked on developing unique microscopic imaging and spectroscopy approaches to study cell and tissue function, as well as, screening assays for cell signaling and ligand binding.Show Less
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Courses
- HPHuman Physiology
- RMPResearch Methods in Physiology
- BBEBiology for Biomedical Engineering
- CMPCellular and Molecular Physiology
- PBEPhysiology for Biomedical Engineering
Grants
- University of Arizona Cancer Center - Cancer Center Support Grant
Key Personnel (KP)
2022
$4.7M
Active - Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes
Co-Investigator (COI)
2020
$4.7M
Active - Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes
Co-Investigator (COI)
2020
$2.2M
Active - Towards Clinical Translation of High Cell-Density Oxygen Enabled Encapsulation Devices in an Allo- and Xeno-Porcine Model
Co-Investigator (COI)
2018
$1.2M
Active - hES-derived Insulin Secreting Cells - Rodent Model In Vivo Characterization
Co-Investigator (COI)
2018
$1.1M
- Targeted Therapeutics for Polycystic Kidney Disease
Co-Investigator (COI)
2017
$749.9K
- University of Arizona Cancer Center - Cancer Center Support Grant
Key Personnel (KP)
2016
$26.3M
- Prevention of Fetal Adrenergic Signaling Improves Metabolic Dysfunction in IUGR
Co-Investigator (COI)
2015
$1.7M
- Towards Clinical Translation of a High Density Encapsulation Devices with Enhanced Oxygen Supply
Key Personnel (KP)
2015
$1.0M
- Graduate Training in Biomedical Imaging and Spectroscopy
Co-Investigator (COI)
2014
$941.2K
News
- Targeting Diabetes: New Agents Track Onset of Disease
2011
- Fetal Programming in Diabetes
2010
- Fighting Disease With Lasers, Light
2010
- Faculty Senate Election Leaves Seats Unfilled
2002
Publications (33)
Recent
- Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction
2020
- Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling
2019
- Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion
2019
- Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices
2019
- In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes
2018
- Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells
2018
- Comment on Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism
2017
- Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans
2017
- Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine
2017
- Linear scaffolds for multivalent targeting of melanocortin receptors
2015
- Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor
2015
- Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium
2015
- A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas
2015
- Trigonal scaffolds for multivalent targeting of melanocortin receptors
2015
- Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302
2015
- Glucagon-like peptide-1 modulation of calcium homeostasis in human coronary microvascular endothelial cells after ischemia and reperfusion.
2014
- Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets
2014
- Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells
2014
- Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy
2014
- Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo
2013
- Simultaneous analysis of intracellular pH and Ca²⁺ from cell populations
2013
- Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting
2013
- Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors
2013
- Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment
2013
- Increased redox-sensitive green fluorescent protein reduction potential in the endoplasmic reticulum following glutathione-mediated dimerization
2013
- Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets
2012
- Keeping the beat. Focus on enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro
2012
- Heterobivalent ligands target cell-surface receptor combinations in vivo
2012
- Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment
2011
- Cell-specific targeting by heterobivalent ligands
2011
- Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.
2011
- Changes in APS sectional programming for EB2011. Expanded programming and meeting-within-a-meeting structure
2010
- Na(+)-K(+)-ATPase and Ca(2+) clearance proteins in smooth muscle: a functional unit
2010