KMap
Research in the Lynch lab focuses on second messenger signaling in nutrient sensing cells (e.g., Pancreatic Beta-Cells) and the vasculature with emphasis on alterations in signaling that occur during development of Diabetes. We develop technologies to modify and analyze beta-cell mass in order to evaluate the initiation of the pre-diabetic state, and efficacy of its treatment. Analysis of subcellular protein distributions, second messenger signaling, and ligand binding are performed using state of the art microscopy and analysis approaches which is a second area of expertise. For over 3 decades, the Lynch lab has worked on developing unique microscopic imaging and spectroscopy approaches to study cell and tissue function, as well as, screening assays for cell signaling and ligand binding.

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Courses
  • HP
    Human Physiology

  • RMP
    Research Methods in Physiology

  • BBE
    Biology for Biomedical Engineering

  • CMP
    Cellular and Molecular Physiology

  • PBE
    Physiology for Biomedical Engineering

Grants
  • Funding agency logo
    University of Arizona Cancer Center - Cancer Center Support Grant

    Key Personnel (KP)

    2022

    $4.7M
    Active
  • Funding agency logo
    Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes

    Co-Investigator (COI)

    2020

    $4.7M
    Active
  • Funding agency logo
    Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes

    Co-Investigator (COI)

    2020

    $2.2M
    Active
  • Funding agency logo
    Towards Clinical Translation of High Cell-Density Oxygen Enabled Encapsulation Devices in an Allo- and Xeno-Porcine Model

    Co-Investigator (COI)

    2018

    $1.2M
    Active
  • Funding agency logo
    hES-derived Insulin Secreting Cells - Rodent Model In Vivo Characterization

    Co-Investigator (COI)

    2018

    $1.1M
  • Funding agency logo
    Targeted Therapeutics for Polycystic Kidney Disease

    Co-Investigator (COI)

    2017

    $749.9K
  • Funding agency logo
    University of Arizona Cancer Center - Cancer Center Support Grant

    Key Personnel (KP)

    2016

    $26.3M
  • Funding agency logo
    Prevention of Fetal Adrenergic Signaling Improves Metabolic Dysfunction in IUGR

    Co-Investigator (COI)

    2015

    $1.7M
  • Funding agency logo
    Towards Clinical Translation of a High Density Encapsulation Devices with Enhanced Oxygen Supply

    Key Personnel (KP)

    2015

    $1.0M
  • Funding agency logo
    Graduate Training in Biomedical Imaging and Spectroscopy

    Co-Investigator (COI)

    2014

    $941.2K
News
  • Targeting Diabetes: New Agents Track Onset of Disease

    2011

  • Fetal Programming in Diabetes

    2010

  • Fighting Disease With Lasers, Light

    2010

  • Faculty Senate Election Leaves Seats Unfilled

    2002

Publications (33)
Recent
  • Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction

    2020

  • Oxygen Perfusion (Persufflation) of Human Pancreata Enhances Insulin Secretion and Attenuates Islet Proinflammatory Signaling

    2019

  • Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion

    2019

  • Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices

    2019

  • In vitro characterization of neonatal, juvenile, and adult porcine islet oxygen demand, β-cell function, and transcriptomes

    2018

  • Adrenergic receptor stimulation suppresses oxidative metabolism in isolated rat islets and Min6 cells

    2018

  • Comment on Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism

    2017

  • Acute Ischemia Induced by High-Density Culture Increases Cytokine Expression and Diminishes the Function and Viability of Highly Purified Human Islets of Langerhans

    2017

  • Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine

    2017

  • Linear scaffolds for multivalent targeting of melanocortin receptors

    2015

  • Development of a time-resolved fluorescence probe for evaluation of competitive binding to the cholecystokinin 2 receptor

    2015

  • Bestrophin-1 influences transepithelial electrical properties and Ca2+ signaling in human retinal pigment epithelium

    2015

  • A Synthetic Heterobivalent Ligand Composed of Glucagon-Like Peptide 1 and Yohimbine Specifically Targets β Cells Within the Pancreas

    2015

  • Trigonal scaffolds for multivalent targeting of melanocortin receptors

    2015

  • Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302

    2015

  • Glucagon-like peptide-1 modulation of calcium homeostasis in human coronary microvascular endothelial cells after ischemia and reperfusion.

    2014

  • Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets

    2014

  • Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells

    2014

  • Synthesis and bioactivity of MSH4 oligomers prepared by an A2 + B2 strategy

    2014

  • Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo

    2013

  • Simultaneous analysis of intracellular pH and Ca²⁺ from cell populations

    2013

  • Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting

    2013

  • Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors

    2013

  • Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment

    2013

  • Increased redox-sensitive green fluorescent protein reduction potential in the endoplasmic reticulum following glutathione-mediated dimerization

    2013

  • Chronic pulsatile hyperglycemia reduces insulin secretion and increases accumulation of reactive oxygen species in fetal sheep islets

    2012

  • Keeping the beat. Focus on enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro

    2012

  • Heterobivalent ligands target cell-surface receptor combinations in vivo

    2012

  • Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment

    2011

  • Cell-specific targeting by heterobivalent ligands

    2011

  • Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

    2011

  • Changes in APS sectional programming for EB2011. Expanded programming and meeting-within-a-meeting structure

    2010

  • Na(+)-K(+)-ATPase and Ca(2+) clearance proteins in smooth muscle: a functional unit

    2010

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