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Lonnie Lybarger

Associate Professor, BIO5 Institute | Associate Professor, Cellular and Molecular Medicine | Associate Professor, Immunobiology | Member of the Graduate Faculty

Cellular & Molecular Medicine
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10+ Collaborators
$401.6K / $435.1K Funding
6+ Publications
10+ Courses

About

My research interests center on the cell biology of antigen presentation within the immune system. We study a family of virus-encoded immune evasion molecules that co-opt host ubiquitin-dependent intracellular trafficking pathways to inhibit antigen presentation. These pathways are explored using biochemical and cell biological techniques.

Research Area

immune activation, immune regulation, ubiquitination, cell signaling, e3 ubiquitin ligase, glucose tolerance, lipid storage, sex-specific regulation, metabolic regulation, immunology

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    Recent

    Intestinal Epithelial MHCII Expression Modulates the Course of Autoimmune and Infectious Colitis

    2020
    immunology, infectious diseases, autoimmunity, intestinal health, epithelial biology

    Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice

    2020
    intestinal, colitis, mhcii, infectious, t-cell

    The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner

    2018
    e3 ubiquitin ligase, glucose tolerance, lipid storage, sex-specific regulation, metabolic regulation

    Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 MARCH1)

    2011

    DC-expressed MHC class I single-chain trimer-based vaccines prime cytotoxic T lymphocytes against exogenous but not endogenous antigens

    2010

    Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression

    2009

    Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation

    2009

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    • Histology of Digestive and Respiratory Systems

    • Mechanisms of Human Disease

    • Histology of Urogenital and Endocrine Systems

    • Basic Immunology

    • Histology Basics

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