Ubiquitination is a post-translational modification process in which a small protein called ubiquitin is attached to target proteins to regulate their stability, localization, and function within the cell. This modification is reversible and plays a crucial role in various cellular processes such as protein degradation, DNA repair, signal transduction, and immune response. Dysregulation of ubiquitination has been implicated in the pathogenesis of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Research in the field of ubiquitination aims to understand the molecular mechanisms underlying this process and its implications for human health and disease.