The University of Arizona
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Janko Nikolich

Professor, BIO5 Institute | Professor, Neuroscience - GIDP | Professor, Genetics - GIDP | Interim Director, AEGIS Center | Department Head, Immunobiology | Professor, Immunobiology | Professor, Nutritional Sciences | Professor, Medicine | Co-Director, Arizona Center on Aging | Member of the Graduate Faculty

Immunobiology

About

Dr. Nikolich-Žugich is internationally recognized as a leading immunologist and gerontologist. He received his M.D. MSc and Ph.D. in Immunology from Belgrade University School of Medicine. From 1987 to 1990, he worked as a Research Associate at the Scripps Clinic and Research Foundation in the laboratory of Dr. Michael J. Bevan, FRS, NAS, HHMI. In 1990, he joined the Memorial Sloan-Kettering Cancer Center in New York as the Head of both the Flow Cytometry Core Facility and the Laboratory of T Cell Development, first as Assistant and then Associate Member. He served as Assistant Professor 1990-1996) and Associate Professor 1996-2001) at both the Cornell University Graduate School of Medical Sciences and the Division of Molecular Medicine in Cornell University School of Medicine. He was a recipient of the Pew Biomedical Scholar Award and the Louise and Allston Boyer Young Scientist Award. In 2001, Dr. Nikolich-Žugich assumed the position of Senior Scientist at the Oregon Health Science University at the Vaccine and Gene Therapy Institute, along with joint appointments as a tenured Professor in the Department of Molecular Microbiology and Immunology and a Senior Scientist at the Oregon National Primate Research Center. In 2008, Dr. Nikolich-Žugich moved to the University of Arizona to lead the Department of Immunobiology and the Arizona Center on Aging. His long-term interests include basic mechanisms of T-cell function, immunity to infection in older adults, vaccines and biomarkers of declining immunity in the elderly, immune rejuvenation, immune monitoring in chronic conditions of aging and the impact of inflammation and nutritional intervention in aging, immunity and metabolic disorders. He has published over 130 scientific papers and reviews describing his work.

Research Area

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    • Our primary research focus is to understand the basic mechanisms of immunity to infectious organisms and how these mechanisms change or deteriorate with age. Our secondary focus is on how longevity- and healthspan- extending interventions intersect with immune defense. We are particularly interested in how aging with persistent herpesviruses may influence immunity to other organisms across the lifespan. We are actively working to identify and test novel strategies, such as thymic rejuvenation, immune modulation, new vaccine approaches and metabolic/nutritional interventions to improve healthspan and immune protection in late life.

    • Advanced Topics: Function, Regulation and Dysregulation of the Immune System

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