Profile

Klearchos Papas

Surgery

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Overview

Research

Collaboration(23)

Page 1 of 5

Grants(35)

Oxygen Enabled High-Capacity Vascularized Devices for Beta-cell Replacement Therapy in Humans
Active·2023·$2.7M·
External
Principal Investigator (PI)
tissue engineering, diabetes, biomedical engineering, regenerative medicine, transplantation
Integrated Islet Distribution Program (U24) - 2021
Active·2023·$300K·
External
Principal Investigator (PI)
islet biology, cell transplantation, diabetes research, biomedical engineering, regenerative medicine
Accelerated Insulin Absorption by Administration Through a Miniature Subcutaneously Implanted Vascularized Chamber
Active·2023·$99.4K·
External
Principal Investigator (PI)
insulin absorption, medical devices, diabetes treatment, implantable devices, drug delivery systems
Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes
Active·2020·$584.9K / $7.6M·
External
Principal Investigator (PI)
stem cells, islet cells, therapy, diabetes, encapsulation
Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes
Active·2020·$4.6M / $4.7M·
External
Principal Investigator (PI)
stem cells, islet cells, therapy, diabetes, encapsulation

Page 1 of 7

Publications(135)

Recent

401.3: The development of a sheemodel for encapsulated cell therapies

2023

cell therapies, biomedical engineering, tissue engineering, biomaterials, modeling

116.2: Dynamic insulin/glucagon measurements from human islet perifusion

2023

insulin, glucagon, islet, perifusion, dynamic

Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?

2023

diabetes treatment, encapsulated cells, acute hypoglycemia, cell encapsulation, diabetes complications

401.4: Sustained hyperoxic exposure decreases cell viability and reduces cell growth in pancreatic beta cell lines

2023

hyperoxia, cell viability, pancreatic beta-cells, cell growth, exposure

401.2: Effects of hyperoxia on human and rat islets

2023

hyperoxia, islet function, human health, rat health, oxygen toxicity

rizona-primo.hosted.exlibrisgroup.comrimo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_4d2c40b1f118487788b0c8b74419747e context=PC vid=01UA lang=en_US search_scope=Everything adaptor=primo_central_multiple_fe tab=default_tab query=any%2Ccontains%2CKlearchos%20Papas offset=0 Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets a

2023

hypoxia, implantable devices, islet viability, tissue engineering, biomedical engineering

Kisspeptin Modulates Mitochondrial Metabolic State and Potentiates Glucose Stimulated Insulin Secretion in INS 832/3 Cells and Pseudo-Islets

2023

mitochondrial metabolism, insulin secretion, kisspeptin, glucose metabolism, cellular energy regulation

Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study

2023

islet transplantation, immune response, allogeneic transplantation, diabetes treatment, biocompatible materials

Development of a Compact NMR System to Measure pO2 in a Tissue-Engineered Graft

2023

nmr, tissue engineering, medical devices, biomedical engineering, oxygen measurement

Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques

2022

immunosuppression, rejection, inflammation, xenotransplant, macaques

People

Profile

Klearchos Papas

Collaboration(23)

Andrew Carnie

Carol Barnes

Ronald Lynch

Josef Vagner

Fiona McCarthy

Grants(35)

Oxygen Enabled High-Capacity Vascularized Devices for Beta-cell Replacement Therapy in Humans

Integrated Islet Distribution Program (U24) - 2021

Accelerated Insulin Absorption by Administration Through a Miniature Subcutaneously Implanted Vascularized Chamber

Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes

Encapsulated hESC Islet Cell Therapy for the Treatment of Diabetes

Publications(135)

401.3: The development of a sheemodel for encapsulated cell therapies

116.2: Dynamic insulin/glucagon measurements from human islet perifusion

Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?

401.4: Sustained hyperoxic exposure decreases cell viability and reduces cell growth in pancreatic beta cell lines

401.2: Effects of hyperoxia on human and rat islets

Kisspeptin Modulates Mitochondrial Metabolic State and Potentiates Glucose Stimulated Insulin Secretion in INS 832/3 Cells and Pseudo-Islets

Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study

Development of a Compact NMR System to Measure pO2 in a Tissue-Engineered Graft

Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques