Profile

Gregory Thatcher

Member of the Graduate Faculty | Professor, Chemistry and Biochemistry | Professor, Pharmacology and Toxicology | Endowed Chair, R Ken and Donna Coit - Drug Discovery

Pharmacology and Toxicology

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Overview

Research

Collaboration(34)

Page 1 of 7

Grants(14)

PARP1 and PARylation as Novel Effectors of Gut Inflammation
Active·2023·$60.8K / $1.3M·
External
Co-Investigator (COI)
inflammation, parp1, gut, parylation, effectors
SRA with Sunshine Biopharma for SARS-CoV-2 PLpro inhibitors
Active·2023·$279.4K / $547.8K·
External
Principal Investigator (PI)
drug development, viral inhibitors, biopharmaceuticals, sars-cov-2, protease inhibitors
Identifying Compounds That Target APOE4 Associated Brain Endothelial Dysfunction
Active·2023·$59.4K·
External
Principal Investigator (PI)
brain health, drug discovery, neuroscience, endothelial function, genetics
Identifying Compounds That Target APOE4 Associated Brain Endothelial Dysfunction
Active·2023·$118.8K / $59.4K·
External
Principal Investigator (PI)
brain health, drug discovery, neuroscience, endothelial function, genetics
Nonlipogenic ABCA1 Inducers for ADRD
Active·2022·$2.2M / $2.6M·
External
Principal Investigator (PI)
alzheimer's disease, cholesterol metabolism, drug discovery, neurodegeneration, lipid transport

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Publications(12)

Recent

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.

2022

drug development, antiviral therapy, enzyme inhibitors, sars-cov-2, protease inhibitors

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

2021

metabolomics, abca1, obesity, therapeutic development, inducer

Extending the Calpain–Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma

2021

neurovasculature, calpain, cathepsin, neurotrauma, brain endothelial cells

Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer’s Disease and Type 2 Diabetes

2021

alzheimer's disease, type 2 diabetes, abca1, nonlipogenic compounds, discovery

Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs

2021

drug development, pharmacology, biochemistry, medicine, cell biology

Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

2021

breast cancer, estrogen mimic, endocrine-resistant, unfolded protein response, apoptosis

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human

2021

neuroinflammation, synaptic proteins, behavior, candesartan treatment, female mice

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

2021

filovirus entry, small molecules, mechanisms, inhibitors, viral entry

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

2021

sars-cov-2, plpro inhibitors, viral replication, monkey cell cultures, human cell cultures

Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments

2021

parasite drug target, thioredoxin glutathione reductase, small molecule fragments, surface probing, drug discovery

People

Profile

Gregory Thatcher

Collaboration(34)

Todd Vanderah

Megha Padi

Nathan Cherrington

Wei Wang

Fayez Ghishan

Grants(14)

PARP1 and PARylation as Novel Effectors of Gut Inflammation

SRA with Sunshine Biopharma for SARS-CoV-2 PLpro inhibitors

Identifying Compounds That Target APOE4 Associated Brain Endothelial Dysfunction

Identifying Compounds That Target APOE4 Associated Brain Endothelial Dysfunction

Nonlipogenic ABCA1 Inducers for ADRD

Publications(12)

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity.

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

Extending the Calpain–Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma

Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer’s Disease and Type 2 Diabetes

Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs

Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer

Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments