Profile

Chris Glembotski

Director, Center for Translational Cardiovascular Research | Member of the Graduate Faculty | Vice Dean, Research | Professor, BIO5 Institute | Professor

College of Medicine - Phoenix

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Overview

Research

Collaboration(15)

Page 1 of 3

Grants(18)

Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1
Active·2024·$37.7K / $754.5K·
External
Co-Investigator (COI)
gene expression regulation, ribosome-binding protein, post-transcriptional regulation
Roles for Endoplasmic Reticulum Associated Degradation (ERAD) in Myocardial Proteostasis
Active·2024·$1.7M / $723.9K·
External
Principal Investigator (PI)
proteostasis, endoplasmic reticulum, myocardial, degradation, erad
Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Active·2024·$150K / $75K·
External
Principal Investigator (PI)
cardiometabolic heart failure, sgk1, preserved ejection fraction, roles, cardiometabolic
PVAHCS IPA for Chase Irwin
Active·2024·$52K·
External
Principal Investigator (PI)
healthcare, medical, veterans, administration, insurance
Mitochondrial Dysfunction Underlies the Integrated Stress Response Activation in Ponatinib-Induced Cardiotoxicity
Active·2023·$53.9K / $1.1M·
External
Co-Investigator (COI)
mitochondrial dysfunction, cardiotoxicity, integrated stress response, ponatinib, activation

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Publications(257)

Recent

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

2024

transcriptomics, endothelial, pulmonary hypertension, fatty acid-binding proteins, arterial programming

ATF6 protects against protein misfolding during cardiac hypertrophy

2024

cardiac hypertrophy, protein misfolding, atf6, cardiac function, cellular stress response

Noncanonical form of ERAD regulates cardiac hypertrophy

2023

cardiac hypertrophy, protein degradation, cellular homeostasis

E2F1 Mediates SOX17 Deficiency–Induced Pulmonary Hypertension

2023

e2f1, sox17, pulmonary hypertension, deficiency, mediation

IRE1α Protects Against Cardiac Fibrosis via Regulating Selective Transcript Degradation

2023

cardiac fibrosis, regulation, heart disease

Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks

2023

nutrition, alzheimer's, brain health, organ pathology, dietary intervention

ER-Specific Autophagy or ER-Phagy in Cardiac Myocytes Protects the Heart Against Doxorubicin-Induced Cardiotoxicity

2023

autophagy, cardiotoxicity, cardiac myocytes, doxorubicin

SGK1 is a Key Mediator of Pathological Cardiac Fibrosis

2023

cardiac fibrosis, sgk1, pathological, mediator

Optimization of Large‐Scale Adeno‐Associated Virus AAV) Production

2023

viral vectors, gene therapy, bioprocessing

mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes

2023

mtorc1 inhibition, unfolded protein response, er stress, cell death, cardiomyocytes

People

Profile

Chris Glembotski

Collaboration(15)

Shenfeng Qiu

Taben Hale

Steven Goldman

Chengcheng Hu

Won Hee Lee

Grants(18)

Post-Transcriptional Regulation of Gene Expression by Ribosome-Binding Protein 1

Roles for Endoplasmic Reticulum Associated Degradation (ERAD) in Myocardial Proteostasis

Roles for SGK1 in Cardiometabolic Heart Failure with Preserved Ejection Fraction

PVAHCS IPA for Chase Irwin

Mitochondrial Dysfunction Underlies the Integrated Stress Response Activation in Ponatinib-Induced Cardiotoxicity

Publications(257)

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

ATF6 protects against protein misfolding during cardiac hypertrophy

Noncanonical form of ERAD regulates cardiac hypertrophy

E2F1 Mediates SOX17 Deficiency–Induced Pulmonary Hypertension

IRE1α Protects Against Cardiac Fibrosis via Regulating Selective Transcript Degradation

Dietary choline intake is necessary to prevent systems‐wide organ pathology and reduce Alzheimer's disease hallmarks

ER-Specific Autophagy or ER-Phagy in Cardiac Myocytes Protects the Heart Against Doxorubicin-Induced Cardiotoxicity

SGK1 is a Key Mediator of Pathological Cardiac Fibrosis

Optimization of Large‐Scale Adeno‐Associated Virus AAV) Production

mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes