Profile

Timothy Marlowe

Research Assistant Professor, Clinical Translational Sciences | Assistant Research Professor, Dermatology | Assistant Research Professor, Internal Medicine | Member of the Graduate Faculty | Research Assistant Professor, Pharmacology and Toxicology

AZ Health Sci Ctrs & Divisions

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Overview

Research

Collaboration(21)

Page 1 of 5

Grants(6)

Validation of Targeting the FAK FAT Domain in Cancer
Active·2023·$42.4K·
External
Principal Investigator (PI)
cancer, targeted therapy, cell signaling, drug development, signal transduction
Focal Adhesion Kinase - Tumor Biology and Therapeutics
Active·2022·$949.4K / $968.8K·
External
Principal Investigator (PI)
cancer, cell biology, therapeutics, molecular biology, cell signaling
Discovery of PPI Inhibitors for the FAK FAT Domain
Active·2022·$192.9K / $385.7K·
External
Principal Investigator (PI)
protein-protein interactions, drug discovery, cancer, pharmacology, cell signaling
Validation of Targeting the FAK FAT Domain in Cancer
2021·$294.1K·
External
Principal Investigator (PI)
cancer, targeted therapy, cell signaling, drug development, tumor microenvironment
Discovery of Novel Peptidic Inhibitors of the Non-Catalytic Function of Focal Adhesion Kinase (FAK)
2019·$82.9K / $87.3K·
External
Principal Investigator (PI)
peptide inhibitors, focal adhesion kinase, drug discovery, protein function, cell signaling

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Publications(10)

Recent

PTK2-associated gene signature could predict the prognosis of IPF

2023

gene expression, prognosis, idiopathic pulmonary fibrosis, biomarkers, ptk2

Novel Non-Catalytic FAK Inhibition Downregulates Lung Fibroblast Matrix Production

2022

inhibition, lung fibroblast, matrix production, fak, non-catalytic

FN-2012, a Small Peptide Inhibitor of the Focal Adhesion Kinase FAK)Paxillin Interaction Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis

2022

liver fibrosis, peptide inhibitor, focal adhesion kinase, hepatic stellate cell, cell activation

Structure-Based Discovery Stapled Peptide PPI Inhibitors of Focal Adhesion Kinase FAK) Scaffolding with a Novel Mechanism of Action and Murine Anticancer Efficacy

2022

drug discovery, cancer treatment, protein-protein interaction, molecular mechanism, kinase inhibitors

Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling

2020

chemical probes, cancer signaling, computational discovery, fak ferm domain, her2 inhibition

Abstract 1032-C: Development of screening platforms to target the “undruggable” focal adhesion targeting FAT) domain

2020

drug development, protein targeting, screening platforms, biomedical research, molecular biology

Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK-Paxillin Interaction

2019

fluorescence assay, protein interaction, high-throughput screening, inhibitor detection, fak-paxillin

Identification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1

2019

rna binding, u2 snrnp protein, sf3a1, non-canonical, identification

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

2019

protein structure, drug targeting, cell signaling, cancer therapy, molecular interactions

Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR

2019

drug discovery, biophysics, biochemistry, protein interaction, structural biology

People

Profile

Timothy Marlowe

Collaboration(21)

Kenneth Knox

Denise Roe

Shenfeng Qiu

Karen Hastings

Anne Cress

Grants(6)

Validation of Targeting the FAK FAT Domain in Cancer

Focal Adhesion Kinase - Tumor Biology and Therapeutics

Discovery of PPI Inhibitors for the FAK FAT Domain

Validation of Targeting the FAK FAT Domain in Cancer

Discovery of Novel Peptidic Inhibitors of the Non-Catalytic Function of Focal Adhesion Kinase (FAK)

Publications(10)

PTK2-associated gene signature could predict the prognosis of IPF

Novel Non-Catalytic FAK Inhibition Downregulates Lung Fibroblast Matrix Production

FN-2012, a Small Peptide Inhibitor of the Focal Adhesion Kinase FAK)Paxillin Interaction Attenuates Hepatic Stellate Cell Activation and Liver Fibrosis

Structure-Based Discovery Stapled Peptide PPI Inhibitors of Focal Adhesion Kinase FAK) Scaffolding with a Novel Mechanism of Action and Murine Anticancer Efficacy

Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling

Abstract 1032-C: Development of screening platforms to target the “undruggable” focal adhesion targeting FAT) domain

Development of a High-Throughput Fluorescence Polarization Assay to Detect Inhibitors of the FAK-Paxillin Interaction

Identification of a noncanonical RNA binding domain in the U2 snRNP protein SF3A1

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site

Development of a Fragment-Based Screening Assay for the Focal Adhesion Targeting Domain Using SPR and NMR