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Profile
Tarjani Thaker
Scientist, Chemistry and Biochemistry
Chemistry & Biochemistry - Science
Overview
Research
More
Collaboration
(4)
Martha Bhattacharya
Mutual work: 1 Grant﹒1 Proposal
Collaboration Details
Andy Powell
Mutual work: 1 Grant
Collaboration Details
Craig Aspinwall
Mutual work: 1 Supervisor
Collaboration Details
Thomas Tomasiak
Mutual work: 2 Grants﹒2 Proposals
Collaboration Details
Grants
(3)
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
Active
·
2023
·
$0 / $434.6K
·
External
undefined (CD)
mtorc1 regulation,
tmem184b function,
synaptic maintenance,
cellular signaling,
protein function
Co-Crystallization of CD8ab with Targeting Antibodies
Active
·
2021
·
$7.7K / $15.5K
·
External
Co-Investigator (COI)
protein crystallization,
immunotherapy,
drug development,
antigen-antibody interaction,
immune system
Biochemical and radiometric analysis of nanoSPA particles
Active
·
2021
·
$12.3K
·
External
Principal Investigator (PI)
nanoparticle analysis,
radiometric analysis,
biochemical analysis,
nanotechnology,
particle characterization
Publications
(17)
Recent
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter
2022
drug binding,
abc transporter,
atp-loaded state,
inward-facing,
asymmetric binding
The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
2022
protein regulation,
transporter regulation,
phosphorylation,
cellular transport,
structural biology
Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface
2021
protein interaction,
cancer,
cell signaling,
structural biology,
biomedical research
Cryo-EM structure of an elusive pre-transport intermediate of the multidrug ABC transporter BmrCD reveals modes of asymmetric drug binding
2021
cryo-em,
abc transporter,
drug binding,
pre-transport,
asymmetric
Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand
2021
protein interactions,
receptor dynamics,
ligand binding,
structural biology,
biomedical research
The role of novel COQ8B mutations in glomerulopathy and related kidney defects
2021
genetics,
kidney disease,
mutations,
glomerulopathy,
coq8b
A conserved motif in intracellular loo1 stabilizes the outward-facing conformation of TmrAB
2021
protein structure,
membrane transport,
cell biology,
biochemistry,
molecular biology
More than the sum of the parts: Toward full‐length receptor tyrosine kinase structures
2019
protein structure,
cell signaling,
biophysics,
molecular biology,
biochemistry
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
2019
protein assemblies,
enzyme function,
polymerization,
cellular signaling,
mitochondrial dynamics
Regulation of kinase activity in the Caenorhabditis elegans EGF receptor, LET-23
2018
kinase activity,
caenorhabditis elegans,
egf receptor,
regulation,
let-23