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Tarjani Thaker
Member of the Graduate Faculty | Assistant Professor
College of Medicine - Tucson
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Research Area
cell signaling,
structural biology,
protein structure,
protein interaction,
molecular biology,
protein interactions,
biophysics,
biochemistry,
cellular signaling,
biomedical research
Grants
(3)
Establishing the Function of TMEM184B in mTORC1 Regulation and Synaptic Maintenance
Active
·
2023
·
$0 / $434.6K
·
External
mtorc1 regulation,
tmem184b function,
synaptic maintenance,
cellular signaling,
protein function
Co-Crystallization of CD8ab with Targeting Antibodies
2021
·
$7.7K / $15.5K
·
External
Co-Investigator (COI)
protein crystallization,
immunotherapy,
drug development,
antigen-antibody interaction,
immune system
Biochemical and radiometric analysis of nanoSPA particles
2021
·
$12.3K
·
External
Principal Investigator (PI)
nanoparticle analysis,
radiometric analysis,
biochemical analysis,
nanotechnology,
particle characterization
Publications
(18)
Recent
The N-terminal signature motif on the transporter MCT1 is critical for CD147-mediated trafficking
2024
protein transport,
cell biology,
protein interaction,
membrane protein,
cellular trafficking
Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter
2022
drug binding,
abc transporter,
atp-loaded state,
inward-facing,
asymmetric binding
The structural basis for regulation of the glutathione transporter Ycf1 by regulatory domain phosphorylation
2022
protein regulation,
transporter regulation,
phosphorylation,
cellular transport,
structural biology
Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand
2021
protein interactions,
receptor dynamics,
ligand binding,
structural biology,
biomedical research
Cryo-EM structure of an elusive pre-transport intermediate of the multidrug ABC transporter BmrCD reveals modes of asymmetric drug binding
2021
cryo-em,
abc transporter,
drug binding,
pre-transport,
asymmetric
Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface
2021
protein interaction,
cancer,
cell signaling,
structural biology,
biomedical research
A conserved motif in intracellular loo1 stabilizes the outward-facing conformation of TmrAB
2021
protein structure,
membrane transport,
cell biology,
biochemistry,
molecular biology
The role of novel COQ8B mutations in glomerulopathy and related kidney defects
2021
genetics,
kidney disease,
mutations,
glomerulopathy,
coq8b
Functional role of PGAM5 multimeric assemblies and their polymerization into filaments
2019
protein assemblies,
enzyme function,
polymerization,
cellular signaling,
mitochondrial dynamics
More than the sum of the parts: Toward full‐length receptor tyrosine kinase structures
2019
protein structure,
cell signaling,
biophysics,
molecular biology,
biochemistry
Collaborations
(3)
Thomas Tomasiak
Mutual work: 2 Grants﹒4 Proposals
Collaboration Details
Martha Bhattacharya
Mutual work: 1 Grant﹒1 Proposal
Collaboration Details
A F M Tariqul Islam
Mutual work: 1 Supervisor
Collaboration Details
Courses
(2)
Introduction to Biochemical Research
Methods of Physical Biochemistry
$20K / $462.4K Funding
10+ Publications
