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Picture of Michael Kuhns

Michael Kuhns

Professor, Cancer Biology - GIDP | Professor, BIO5 Institute | Senior Scientific Advisor, Center for Advanced Molecular & Immuno Therapies | Member of the Graduate Faculty | Professor, Genetics - GIDP | Professor, Immunobiology

Collaboration(21)

Janko Nikolich
Anne Cress
Karen Hastings
Jacobus Barnard
Ali Akoglu

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Grants(16)

Evolution-guided Analysis of Extracellular and Intracellular Mechanisms Driving T Cell Activation
Active·2024·$392.4K / $682.4K·
External
Principal Investigator (PI)
evolution, t cell activation, intracellular mechanisms, extracellular mechanisms, analysis
Infection and Inflammation as Drivers of Aging (IIDA) Predoctoral Training Program
Active·2024·$0 / $292.3K·
External
aging, infection, inflammation, pre-doctoral, training
A Phospholipid-Derived Nanotherapeutic Platform for Improved Colorectal Cancer Immunochemotherapy
Active·2023·$33.6K / $672.5K·
External
Co-Investigator (COI)
nanotherapeutic, colorectal cancer, phospholipid-derived, immunochemotherapy, improved platform
PVAHCS IPA for Michael Kuhns
Active·2023·$0 / $11.8K·
External
Key Personnel (KP)
healthcare, patient care, medical records, health information technology, insurance
Engineering 2nd Generation 5MCARs to Monitor and Treat Type-I Diabetes
Active·2022·$2.5M·
External
Principal Investigator (PI)
diabetes, bioengineering, medical devices, health monitoring, gene therapy

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Publications(26)

Recent

The CD4 transmembrane GGXXG and juxtamembrane C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

2023

cell signaling, cd4 receptor, immune system, transmembrane signaling, protein motifs

The TCR Cα Domain Regulates Responses to Self-pMHC Class II

2022

immunology, t-cell receptor, autoimmunity, peptide-mhc interaction, regulatory t cells

Enhancing and inhibitory motifs regulate CD4 activity

2022

immunology, protein regulation, cell signaling, molecular biology, biochemistry

A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice

2018

ageing, immunology, t-cell, immune response, mouse model

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

2018

t-cell receptor, cd4 engagement, pmhcii stabilization, receptor macrocomplex, nucleating interaction

Domain-swapped T cell receptors improve the safety of TCR gene therapy

2016

t cell receptors, tcr gene therapy, safety, domain-swapped, gene therapy

Functional evidence for TCR-intrinsic specificity for MHCII

2016

t-cell receptor, mhc class ii, immunology, cell biology, protein interactions

The CD4 and CD3δε Cytosolic Juxtamembrane Regions Are Proximal within a Compact TCR-CD3-pMHC-CD4 Macrocomplex

2016

tcr-cd3-pmhc-cd4, cytosolic juxtamembrane, cd4, cd3δε, pmhc

A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization

2015

transmembrane domain, cd4 function, lck-independent function, cd4 dimerization, ggxxg motif

Self-recognition drives the preferential accumulation of promiscuous CD4( T-cells in aged mice

2015

immunology, aging, cell biology, immunosenescence, t cell repertoire