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Picture of Lalitha Madhavan

Lalitha Madhavan

Associate Professor, Neurology | Associate Professor, BIO5 Institute | Associate Professor, Clinical Translational Sciences | Associate Professor, Molecular and Cellular Biology | Associate Professor, Medicine | Associate Professor, Evelyn F McKnight Brain Institute | Associate Professor, Applied BioSciences - GIDP | Associate Professor, Neuroscience - GIDP | Associate Professor, Physiological Sciences - GIDP | Member of the Graduate Faculty

Collaboration(40)

Helena Morrison
Baldassarre Stea
Todd Vanderah
Carol Barnes
Gene Alexander

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Grants(10)

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Publications(43)

Recent

The angiotensin 1–7) glycopeptide PNA5 improves cognition in a chronic progressive mouse model of Parkinson's disease through modulation of neuroinflammation

2024

neuroinflammation, parkinson's disease, cognition, mouse model

Erratum to “NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice”

2024

parkinson's disease, nrf2, behavioral dysfunction, alpha-synuclein, neurodegeneration

Parallel neurodegenerative phenotypes in sporadic Parkinson’s disease fibroblasts and midbrain dopamine neurons

2023

parkinson's disease, neurodegeneration, fibroblasts

The hyper) excitable brain: what can a ubiquitous TMS measure reveal about cognitive aging?

2023

cognitive aging, tms, brain excitability, neuroscience, cognitive function

Design and synthesis of brain penetrant glycopeptide analogues of PACAP with neuroprotective potential for traumatic brain injury and parkinsonism

2022

α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease

2022

parkinson's disease, neuronal loss, ferroptosis, α-syn overexpression, nrf2 suppression

Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAFV600E/NRASQ61K malignant melanoma cells targeting intracranial tumors in a …

2022

cancer, drug development, apoptosis, er stress, intracranial tumors

639 Identification of experimental therapeutics overcoming NRAS-based BRAFi-resistant malignant melanoma targeting brain metastases in a bioluminescent murine model

2022

cancer therapy, braf inhibitor resistance, melanoma, brain metastases, experimental therapeutics

Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging

2021

aging, neural stem cells, nrf2 expression, cell function, neuroscience

NRF2 loss accentuates parkinsonian pathology and behavioral dysfunction in human α-synuclein overexpressing mice

2021

parkinson's disease, neurodegeneration, alpha-synuclein, nrf2, behavioral dysfunction