Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a crucial role in the regulation of antioxidant and detoxification gene expression. It is involved in the cellular response to oxidative stress and is known to activate various genes involved in the phase II detoxification process, as well as genes encoding antioxidant proteins. Research in the area of Nrf2 focuses on understanding its regulatory mechanisms, its role in various diseases such as cancer, neurodegenerative diseases, and inflammatory disorders, and its potential as a therapeutic target for mitigating oxidative stress and inflammation. Studies in this field aim to develop strategies to modulate the activity of Nrf2 for the prevention and treatment of various health conditions.