Profile

Nicholas Delamere

Member of the Graduate Faculty | Professor, Physiology | Professor, Ophthalmology | Professor, BIO5 Institute

Physiology

Full Page

Overview

Research

Collaboration(7)

Page 1 of 2

Grants(9)

TRP Channels as Master Controllers of Lens Function
Active·2021·$725.5K / $1.6M·
External
Principal Investigator (PI)
ion channels, ocular function, biophysics, cell signaling, sensory physiology
Hemichannels, TRPV4 and a Mechanosensitive Form of Autocrine Regulation in the NPE
Active·2019·$2M / $2.2M·
External
Principal Investigator (PI)
gap junctions, trpv4, autocrine regulation, mechanosensitive channels, cell signaling
TRP-Channels in Lens Development and Cataract
Active·2019·$43.3K / $45.6K·
External
Principal Investigator (PI)
lens development, cataract, trp channels, ophthalmology, cell biology
Do Horses, During Equine Facilitated Learning, Influence Elder Adults to Focus on the Present Moment Leading to Enhanced Heart Rate Variability, Blood Pressure Regulation and Social Behaviors?
2018·$167.9K·
External
Principal Investigator (PI)
equine facilitated learning, heart rate variability, social behaviors, blood pressure regulation, elder adults
TRPV4 as a Remote Controller of Lens Function
2016·$1.7M / $1.8M·
External
Principal Investigator (PI)
trpv4, lens function, remote control, channelopathies, ocular biology

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Publications(146)

Recent

A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens

2024

cataract, mutation, calcium dynamics, trpm3 cation channel, lens

Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium

2023

mechanotransduction, ion channels, cell signaling, ciliary epithelium, mechanical stress

Patch clamstudies on TRPV4-dependent hemichannel activation in lens epithelium

2023

ion channels, epithelial cells, lens, cell signaling, visual system

NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients

2022

nmda receptors, sodium elevations, olfactory neuroepithelial, bipolar patients, inhibition

Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens

2022

ion transport, piezo1 activation, na, k-atpase, mouse lens, cell signaling

Ion Transport Regulation by TRPV4 and TRPV1 in Lens and Ciliary Epithelium

2021

ion transport, trpv4 and trpv1, lens, ciliary epithelium, regulation

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens

2020

cell signaling, trpv channels, lens physiology, hydrostatic pressure, mouse model

TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens

2020

trpv1 activation, nkcc1 stimulation, hydrostatic pressure, mouse lens, ion channels

Terbutaline, forskolin and cAMP reduce secretion of aqueous humour in the isolated bovine eye

2020

ocular pharmacology, intraocular pressure, eye physiology, cyclic adenosine monophosphate (camp), drug effects on aqueous humour secretion

Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice

2018

neuronal development, gene expression regulation, potassium homeostasis, mecp2 deficiency, animal model

People

Profile

Nicholas Delamere

Collaboration(7)

George Watts

Mohammad Shahidullah

Ralph Fregosi

Achyut Bhattacharyya

Richard Levine

Grants(9)

TRP Channels as Master Controllers of Lens Function

Hemichannels, TRPV4 and a Mechanosensitive Form of Autocrine Regulation in the NPE

TRP-Channels in Lens Development and Cataract

Do Horses, During Equine Facilitated Learning, Influence Elder Adults to Focus on the Present Moment Leading to Enhanced Heart Rate Variability, Blood Pressure Regulation and Social Behaviors?

TRPV4 as a Remote Controller of Lens Function

Publications(146)

A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens

Mechanical Stretch Activates TRPV4 and Hemichannel Responses in the Nonpigmented Ciliary Epithelium

Patch clamstudies on TRPV4-dependent hemichannel activation in lens epithelium

NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients

Activation of Piezo1 Increases Na,K-ATPase-Mediated Ion Transport in Mouse Lens

Ion Transport Regulation by TRPV4 and TRPV1 in Lens and Ciliary Epithelium

Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens

TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens

Terbutaline, forskolin and cAMP reduce secretion of aqueous humour in the isolated bovine eye

Correcting deregulated Fxyd1 expression rescues deficits in neuronal arborization and potassium homeostasis in MeCP2 deficient male mice