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Jeffrey Lochhead
Assistant Research Professor, Pharmacology - (Research Series Track)
Pharmacology
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Research Area
blood-brain barrier,
drug delivery,
central nervous system,
intranasal administration,
neuroprotection,
ischemic stroke,
neuroscience,
atorvastatin,
acetaminophen,
transporters
Grants
(3)
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Publications
(30)
Recent
Oat(Organic Anion Transporting Polypeptide)Mediated Transport: A Mechanism for Atorvastatin Neuroprotection in Stroke
2023
drug transport,
neuroprotection,
stroke,
organic anion transporting polypeptide,
atorvastatin
Endogenous Blood-Brain Barrier Uptake Transport is Required for Neuroprotective Efficacy of Atorvastatin in Acute Ischemic Stroke.
2022
blood-brain barrier,
neuroprotective efficacy,
atorvastatin,
acute ischemic stroke,
endogenous transport
High Resolution Multiplex Confocal Imaging of the Neurovascular Unit in Health and Experimental Ischemic Stroke
2022
neuroimaging,
ischemic stroke,
neurovascular unit,
high-resolution imaging,
experimental research
Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-Activin Receptor-Like Kinase 1 Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors i.e. Statins)
2022
blood-brain barrier,
transporters,
signaling pathways,
brain disposition,
statins
β-spectrin as a stalk cell-intrinsic regulator of VEGF signaling
2022
cell signaling,
β-spectrin,
vegf regulation,
stalk cells,
cell biology
High-Dose Acetaminophen Alters the Integrity of the Blood-Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats
2022
acetaminophen,
blood-brain barrier,
cns uptake,
codeine,
rat model
Memantine requires transcellular transport mediated by organic cation transporters at the blood-brain barrier to exert neuroprotective effects in ischemic stroke
2021
neuroprotective effects,
transcellular transport,
blood-brain barrier,
organic cation transporters,
ischemic stroke
Involvement of endogenous blood-brain barrier transporters in the regional disposition of 3-hydroxy-3-methylglutaryl coenzyme A HMG-CoA) reductase inhibitors in the brain.
2021
blood-brain barrier transporters,
drug disposition,
hmg-coa reductase inhibitors,
brain pharmacokinetics,
neuropharmacology
Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders
2020
blood-brain barrier,
tight junctions,
central nervous system,
structure,
regulation
Abstract TP121: Organic Anion Transporting Polypeptide Oatp)Mediated Transport is Required for Statin-Induced Neuroprotection: A Role for Blood-Brain Barrier Transporters in Stroke Treatment
2020
neuroprotection,
blood-brain barrier,
stroke treatment,
organic anion transporters,
statin-induced transport
Collaborations
(4)
Tally Largent-Milnes
Mutual work: 1 Proposal
Collaboration Details
Patrick Ronaldson
Mutual work: 15 Proposals﹒13 Publications﹒2 Grants
Collaboration Details
Thomas Davis
Mutual work: 2 Grants﹒16 Publications﹒11 Proposals
Collaboration Details
Sharon Hom
Mutual work: 1 Publication
Collaboration Details
Courses
(1)
Molecular Targets of Pharmacological Agents
$789.2K / $5.8M Funding
30+ Publications
