Research Professor, Internal Medicine | Member of the Graduate Faculty | Professor, Clinical Translational Sciences
Dr. Gladysheva’s research is focused on the molecular and pathophysiologic mechanisms of cardiomyopathy, heart failure and concurrent complications in order to delay or prevent transition from cardiac dysfunction cardiomyopathy) to symptomatic heart failure. Specifically, we are interested in proteases and hormones as potential diagnostic and therapeutic targets, and not pharmacological approaches life-style choices) to modulate progression of cardiomyopathy and heart failure.
A grant titled 'Factor XIIa is the Long-sought Activator of Circulating Renin in Heart Failure' has been awarded by the DPT of Health & Human Services. Dr. Inna Gladysheva from COM Phx Internal Medicine will lead the research. The project aims to understand how the protein Factor XIIa contributes to heart failure by activating renin, a key regulator of the renin-angiotensin-aldosterone system.
- The study focuses on heart failure with reduced ejection fraction (HFrEF), a common and deadly condition.
- Researchers will investigate how Factor XIIa activates renin in the circulation, potentially leading to novel strategies to prevent HFrEF progression and death.
- The project combines enzymology, biomarker analysis, and heart failure modeling in vivo to explore the role of FXIIa in heart failure.
- The long-term goal is to discover new therapeutic strategies to block or prevent the progression of HFrEF.