Cynthia Miranti

Professor, Cellular and Molecular Medicine | Interim Department Head, Cellular and Molecular Medicine | Professor, BIO5 Institute | Member of the Graduate Faculty | Chair, Cancer Biology - GIDP

Cellular & Molecular Medicine

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20+ Collaborators

$2.8M / $30.4M Funding

9+ Grants

60+ Publications

Research Area

prostate cancer, cell differentiation, cancer, tumor microenvironment, gene expression, androgen receptor, metastasis, tetraspanin cd82, cell biology, cancer research, notch3, gene regulation, cancer biology, drug resistance, immunology

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Recent

Microfluidic-based human prostate cancer on chip.

2024

cancer, microfluidics, medical research, biomedical engineering, organ-on-a-chip

AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production.

2024

prostate cancer, stromal morphogen production, nf-κb signaling, p38-mapk signaling, ar loss

PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion

2023

cancer, cell biology, protein kinases, tumor invasion, actin dynamics

PIM kinases regulate actin dynamics and tumor cell invasion in hypoxia

2023

kinase regulation, actin dynamics, tumor cell invasion, hypoxia response, cancer biology

Building capacity for collaborative research between basic scientists and underrepresented communities in cancer research

2023

cancer research, collaborative research, community engagement, capacity building, basic science

Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation.

2021

prostate cancer, cell differentiation, creb1 activation, luminal cells, aberrant activation

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

2021

cancer, angiogenesis, protein kinase, hif-1α, tumor microenvironment

Targeted Phage Display-based Pulmonary Vaccination in Mice and Non-human Primates

2021

vaccination, phage display, pulmonary delivery, immunization, animal models

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

2020

gene regulation, transcription, nucleolin, g-quadruplex, androgen receptor

Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer

2020

prostate cancer, pi3k inhibitors, androgen receptor, cell survival, drug resistance

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Cancer Biology Clinical Experience
Advanced Topics in Cancer Biology
Cancer Biology
Scientific Grantsmanship

Bio-Engineered Human Prostate Disease Model
2023·Technology
G-Quadruplex Targeting Small Molecules for the Treatment of Castration Resistant Prostate Cancer and HSV-1
2018·Technology

Cynthia Miranti

Research Area

Grants(10)

Publications(68)

Microfluidic-based human prostate cancer on chip.

AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production.

PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion

PIM kinases regulate actin dynamics and tumor cell invasion in hypoxia

Building capacity for collaborative research between basic scientists and underrepresented communities in cancer research

Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation.

Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors

Targeted Phage Display-based Pulmonary Vaccination in Mice and Non-human Primates

Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex

Androgen receptor-induced integrin α6β1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer

Collaborations(28)

Cynthia Thomson

Denise Roe

Rachna Shroff

Benjamin Lee

Megha Padi

Courses(4)

Cancer Biology Clinical Experience

Advanced Topics in Cancer Biology

Cancer Biology

Scientific Grantsmanship

Techs/Patents(2)

Bio-Engineered Human Prostate Disease Model

G-Quadruplex Targeting Small Molecules for the Treatment of Castration Resistant Prostate Cancer and HSV-1