Dr. Hamilton's research interests involve emerging technologies and methodologies that assist physicians, healthcare professionals, and healthcare delivery systems in eliminating preventable adverse medical events. His research focuses on quality assurance in human systems and performance as well as the development of informatics, artificial intelligence, “smart” artificial tissues, robotics, and “hard” versus “thick” data analysis. Dr. Hamilton is also involved in the development of new technologies to make surgery safer, innovative methods for training interprofessional healthcare teams, and new ways to create patient-specific anatomical models to provide surgeons with a better understanding of what a surgical procedure will require to produce the safest and most efficient outcomes. Dr. Hamilton's research goal is to create a healthcare system that is free of preventable errors through the use of a multi-disciplinary facility capable of simulating any healthcare environment or procedure and to ensure that the University of Arizona produces the best trained and most compassionate healthcare providers in the world. Dr. Hamilton is currently the PI or co-PI for research funding from the NIH, the NSF, and external bio-industrial sources. These research projects include developing and evaluating the next generation of laparoscopes, looking at self-guided robotics for surgery, and designing and developing prototype “smart” artificial tissues that are capable of bleeding and responding with changes in vascular supply, volume, and color that mimic tissue changes induced by ischemia, hypoxia, and direct mechanical trauma.