Phospholipase enzymes are a group of enzymes that play a key role in the breakdown of phospholipids, which are important components of cell membranes. These enzymes catalyze the hydrolysis of the ester bonds in phospholipids, resulting in the release of fatty acids and other bioactive lipid molecules. Phospholipases are involved in various biological processes, including cell signaling, lipid metabolism, and inflammation. Dysregulation of phospholipases has been implicated in several human diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Research in this area focuses on understanding the biochemical and physiological functions of different phospholipase enzymes, as well as developing inhibitors and modulators for potential therapeutic applications.