KMap
Courses
  • B
    Biochemistry

  • BSI
    Biological Structure I

  • BS
    Biological Structure 2

  • IBR
    Introduction to Biochemical Research

  • NAM
    Nucleic Acids, Metabolism, and Signaling

Student Thesis/Dissertation
  • INVESTIGATING TDP-43-MEDIATED TRANSLATIONAL REPRESSION IN MOTOR NEURONS IN A DROSOPHILA MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

    2022

    bachelors
  • EVALUATING NOVEL THERAPIES FOR NEURODEGENERATIVE DISEASES USING DROSOPHILA MODELS

    2021

    bachelors
  • Intrinsic Local Balancing of Hydrophobic and Hydrophilic Residues in Folded Protein Sequences

    2016

    doctoral
  • Mechanisms and Consequences of Evolving a New Protein Fold

    2016

    doctoral
  • A Reduction in Structural Specificity by Polar-to-Hydrophobic Surface Substitutions in the Arc Repressor Protein: A Romance of Three Folds

    2014

    doctoral
  • Novel Product Formation and Substrate Specificity of the Phospholipase D Toxins in the Venom of the Sicariidae Spider Family

    2014

    doctoral
Grants
  • Funding agency logo
    MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research

    Co-Investigator (COI)

    2020

    $342.9K
    Active
  • Funding agency logo
    Collaborative Research: Head Group Preference in Recluse Spider Phospholipase D Toxins

    Principal Investigator (PI)

    2018

    $405.0K
    Active
  • Funding agency logo
    The Conversion of Noncoding Sequences Into Proteins

    Principal Investigator (PI)

    2013

    $835.3K
  • Funding agency logo
    Conformational Switching in Proteins

    Principal Investigator (PI)

    2008

    $1.3M
  • Funding agency logo
    CAREER: The Functional Evolution of Sequence-Specific DNA-Binding Proteins

    Principal Investigator (PI)

    2007

    $697.5K
News
  • Birth of a New Protein: How Evolution Does More Than Tinker

    2017

  • Spider Venom Reveals New Secret

    2013

  • BIO5 Institute Funds Eight Collaborative Pilot Grants

    2012

  • The Age of Biology is Here

    2008

  • Researchers Tackling Unsolved Questions About Protein Structures

    2008

  • Department of Biochemistry to Hold First Departmental Reunion

    2001

Publications (37)
Recent
  • Studying protein fold evolution with hybrids of differently folded homologs

    2015

  • Variable Substrate Preference Among Phospholipase D Toxins From Sicariid Spiders

    2015

  • Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products

    2015

  • The Recent De Novo Origin of Protein C-Termini

    2015

  • A polymetamorphic protein

    2013

  • A role for indels in the evolution of Cro protein folds

    2013

  • Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates

    2013

  • The porous borders of the protein world

    2012

  • Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences

    2011

  • Reengineering Cro protein functional specificity with an evolutionary code

    2011

  • Measuring su1 suH suN su temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy

    2011

  • A simple method for measuring signs of 1HN chemical shift differences between ground and excited protein states

    2010

  • Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms

    2009

  • Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA

    2008

  • N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces

    2008

  • Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

    2008

  • Structural features and the persistence of acquired proteins

    2008

  • Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage 955;

    2007

  • A trade between similar but nonequivalent intrasubunit and intersubunit contacts in Cro dimer evolution

    2006

  • Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria

    2006

  • High polar content of long buried blocks of sequence in protein domains suggests selection against amyloidogenic non-polar sequences

    2006

  • Relationshibetween sequence determinants of stability for two natural homologous proteins with different folds

    2006

  • Sphingomyelinase D from venoms of Loxosceles spiders: Evolutionary insights from cDNA sequences and gene structure

    2005

  • Sequence determinants of a conformational switch in a protein structure

    2005

  • Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition

    2005

  • Networking at the Protein Society symposium.

    2005

  • Secondary structure switching in Cro protein evolution

    2004

  • Retroevolution of lambda Cro toward a stable monomer

    2003

  • Solution structure of switch Arc, a mutant with 3 sub 10 sub helices replacing a wild-type 946;ribbon

    2003

  • An evolutionary bridge to a new protein fold

    2000

  • Evolution of a protein fold in vitro

    1999

  • Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions

    1999

  • Medium effects on the rates of stereomutation of a pair of diastereomeric cyclopropanones. Ground state stabilization in nucleophilic solvents induces deviation from solvent polarity controlled behavior

    1996

  • Sequence space, folding and protein design

    1996

  • Stereochemistry of a cyclopropanone by crystal structure analysis. The exo configuration of the diels-alder adduct of cyclopropenone and 1,3-diphenylisobenzofuran appears to be stabilized relative to the endo by an attractive ether-carbonyl interaction

    1994

  • Inhibition of rabbit lung angiotensin-converting enzyme by N(α)S)1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N(α)S)1-carboxy-3-phenylpropyl]L-lysyl-L-proline

    1985

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