Photo of Matthew Cordes(cordes)

Matthew Cordes

Associate Professor, BIO5 Institute,
Associate Professor, Chemistry and Biochemistry-Sci,
Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
UAVitae logo
Grant: $3.5M
Matthew Cordes experts in bioinformatics, computational biology, molecular evolution, biochemistry, molecular biology, systems biology, structural biology, microbiology, venom, biophysics, pharmacology, inorganic chemistry, organic chemistry, bioinorganic chemistry, polymer chemistry, materials science, phylogenetics, microbial ecology, machine learning, immunology, virology, dna repair, molecular dynamics, nmr spectroscopy, sphingolipids, enzymology, entomology
Biological Structure 2 
Biological Structure I 
Introduction to Biochemical Research 
Nucleic Acids, Metabolism, and Signaling 
Recent Grants
Logo of MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research funding agency
2020 $342.9KActive
MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
Logo of Collaborative Research: Head Group Preference in Recluse Spider Phospholipase D Toxins funding agency
2018 $405.0KActive
Collaborative Research: Head Group Preference in Recluse Spider Phospholipase D Toxins
Logo of The Conversion of Noncoding Sequences Into Proteins funding agency
2013 $835.3K
The Conversion of Noncoding Sequences Into Proteins
Logo of Conformational Switching in Proteins funding agency
2008 $1.3M
Conformational Switching in Proteins
Logo of CAREER: The Functional Evolution of Sequence-Specific DNA-Binding Proteins funding agency
2007 $697.5K
CAREER: The Functional Evolution of Sequence-Specific DNA-Binding Proteins
2017Birth of a New Protein: How Evolution Does More Than Tinker 
2013Spider Venom Reveals New Secret 
2012BIO5 Institute Funds Eight Collaborative Pilot Grants 
2008The Age of Biology is Here 
2008Researchers Tackling Unsolved Questions About Protein Structures 
2001Department of Biochemistry to Hold First Departmental Reunion 
Publications (37)
2015The Recent De Novo Origin of Protein C-Termini 
2015Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products 
2015Studying protein fold evolution with hybrids of differently folded homologs 
2015Variable Substrate Preference Among Phospholipase D Toxins From Sicariid Spiders 
2013A role for indels in the evolution of Cro protein folds 
2013Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates 
2013A polymetamorphic protein 
2012The porous borders of the protein world 
2011Measuring sup 1 /sup H sup N /sup temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy 
2011Determinants of gas-phase disassembly behavior in homodimeric protein complexes with related yet divergent structures 
2011Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences 
2011Reengineering Cro protein functional specificity with an evolutionary code 
2010A simple method for measuring signs of 1HN chemical shift differences between ground and excited protein states 
2009Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms 
2008Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA 
2008Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds 
2008Structural features and the persistence of acquired proteins 
2008N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces 
2007Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage λ 
2006Relationship between sequence determinants of stability for two natural homologous proteins with different folds 
2006Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria 
2006A trade between similar but nonequivalent intrasubunit and intersubunit contacts in Cro dimer evolution 
2006High polar content of long buried blocks of sequence in protein domains suggests selection against amyloidogenic non-polar sequences 
2005Sequence determinants of a conformational switch in a protein structure 
2005Networking at the Protein Society symposium. 
2005Sphingomyelinase D from venoms of Loxosceles spiders: Evolutionary insights from cDNA sequences and gene structure 
2005Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition 
2004Secondary structure switching in Cro protein evolution 
2003Solution structure of switch Arc, a mutant with 3 sub 10 /sub helices replacing a wild-type β-ribbon 
2003Retroevolution of lambda Cro toward a stable monomer 
2000An evolutionary bridge to a new protein fold 
1999Evolution of a protein fold in vitro 
1999Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions 
1996Sequence space, folding and protein design 
1996Medium effects on the rates of stereomutation of a pair of diastereomeric cyclopropanones. Ground state stabilization in nucleophilic solvents induces deviation from solvent polarity controlled behavior 
1994Stereochemistry of a cyclopropanone by crystal structure analysis. The exo configuration of the diels-alder adduct of cyclopropenone and 1,3-diphenylisobenzofuran appears to be stabilized relative to the endo by an attractive ether-carbonyl interaction 
1985Inhibition of rabbit lung angiotensin-converting enzyme by N(α)-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N(α)-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline