KMap
Courses
- BBiochemistry
- BSIBiological Structure I
- BSBiological Structure 2
- IBRIntroduction to Biochemical Research
- NAMNucleic Acids, Metabolism, and Signaling
Student Thesis/Dissertation
- INVESTIGATING TDP-43-MEDIATED TRANSLATIONAL REPRESSION IN MOTOR NEURONS IN A DROSOPHILA MODEL OF AMYOTROPHIC LATERAL SCLEROSIS
2022
bachelors - EVALUATING NOVEL THERAPIES FOR NEURODEGENERATIVE DISEASES USING DROSOPHILA MODELS
2021
bachelors - Intrinsic Local Balancing of Hydrophobic and Hydrophilic Residues in Folded Protein Sequences
2016
doctoral - Mechanisms and Consequences of Evolving a New Protein Fold
2016
doctoral - A Reduction in Structural Specificity by Polar-to-Hydrophobic Surface Substitutions in the Arc Repressor Protein: A Romance of Three Folds
2014
doctoral - Novel Product Formation and Substrate Specificity of the Phospholipase D Toxins in the Venom of the Sicariidae Spider Family
2014
doctoral
Grants
- MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
Co-Investigator (COI)
2020
$342.9KActive - Collaborative Research: Head Group Preference in Recluse Spider Phospholipase D Toxins
Principal Investigator (PI)
2018
$405.0KActive - The Conversion of Noncoding Sequences Into Proteins
Principal Investigator (PI)
2013
$835.3K - Conformational Switching in Proteins
Principal Investigator (PI)
2008
$1.3M - CAREER: The Functional Evolution of Sequence-Specific DNA-Binding Proteins
Principal Investigator (PI)
2007
$697.5K
News
- Birth of a New Protein: How Evolution Does More Than Tinker
2017
- Spider Venom Reveals New Secret
2013
- BIO5 Institute Funds Eight Collaborative Pilot Grants
2012
- The Age of Biology is Here
2008
- Researchers Tackling Unsolved Questions About Protein Structures
2008
- Department of Biochemistry to Hold First Departmental Reunion
2001
Publications (37)
Recent
- Studying protein fold evolution with hybrids of differently folded homologs
2015
- Variable Substrate Preference Among Phospholipase D Toxins From Sicariid Spiders
2015
- Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products
2015
- The Recent De Novo Origin of Protein C-Termini
2015
- A polymetamorphic protein
2013
- A role for indels in the evolution of Cro protein folds
2013
- Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates
2013
- The porous borders of the protein world
2012
- Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences
2011
- Determinants of gas-phase disassembly behavior in homodimeric protein complexes with related yet divergent structures
2011
- Reengineering Cro protein functional specificity with an evolutionary code
2011
- Measuring su1 suH suN su temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy
2011
- A simple method for measuring signs of 1HN chemical shift differences between ground and excited protein states
2010
- Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms
2009
- Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA
2008
- N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces
2008
- Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds
2008
- Structural features and the persistence of acquired proteins
2008
- Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage 955;
2007
- A trade between similar but nonequivalent intrasubunit and intersubunit contacts in Cro dimer evolution
2006
- Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria
2006
- High polar content of long buried blocks of sequence in protein domains suggests selection against amyloidogenic non-polar sequences
2006
- Relationshibetween sequence determinants of stability for two natural homologous proteins with different folds
2006
- Sphingomyelinase D from venoms of Loxosceles spiders: Evolutionary insights from cDNA sequences and gene structure
2005
- Sequence determinants of a conformational switch in a protein structure
2005
- Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition
2005
- Networking at the Protein Society symposium.
2005
- Secondary structure switching in Cro protein evolution
2004
- Retroevolution of lambda Cro toward a stable monomer
2003
- Solution structure of switch Arc, a mutant with 3 sub 10 sub helices replacing a wild-type 946;ribbon
2003
- An evolutionary bridge to a new protein fold
2000
- Evolution of a protein fold in vitro
1999
- Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions
1999
- Medium effects on the rates of stereomutation of a pair of diastereomeric cyclopropanones. Ground state stabilization in nucleophilic solvents induces deviation from solvent polarity controlled behavior
1996
- Sequence space, folding and protein design
1996
- Stereochemistry of a cyclopropanone by crystal structure analysis. The exo configuration of the diels-alder adduct of cyclopropenone and 1,3-diphenylisobenzofuran appears to be stabilized relative to the endo by an attractive ether-carbonyl interaction
1994
- Inhibition of rabbit lung angiotensin-converting enzyme by N(α)S)1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N(α)S)1-carboxy-3-phenylpropyl]L-lysyl-L-proline
1985
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