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Matthew Cordes

Associate Professor, BIO5 Institute,

Associate Professor, Chemistry and Biochemistry-Sci,

Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
cordes@arizona.edu

520/626-1175

Grant: $3.5M

Matthew Cordes experts in bioinformatics, computational biology, molecular evolution, biochemistry, molecular biology, systems biology, structural biology, microbiology, venom, biophysics, pharmacology, inorganic chemistry, organic chemistry, bioinorganic chemistry, polymer chemistry, materials science, phylogenetics, microbial ecology, machine learning, immunology, virology, dna repair, molecular dynamics, nmr spectroscopy, sphingolipids, enzymology, entomology

Courses

Biological Structure 2

Biological Structure I

Introduction to Biochemical Research

Biochemistry

Nucleic Acids, Metabolism, and Signaling

Recent Grants

	2020	$342.9K	Active
MRI: Acquisition of a State-of-the-Art Analytical Ultracentrifuge (AUC) For Biomedical and Materials Research
	2018	$405.0K	Active
Collaborative Research: Head Group Preference in Recluse Spider Phospholipase D Toxins
	2013	$835.3K
The Conversion of Noncoding Sequences Into Proteins
	2008	$1.3M
Conformational Switching in Proteins
	2007	$697.5K
CAREER: The Functional Evolution of Sequence-Specific DNA-Binding Proteins

News

2017	Birth of a New Protein: How Evolution Does More Than Tinker
2013	Spider Venom Reveals New Secret
2012	BIO5 Institute Funds Eight Collaborative Pilot Grants
2008	The Age of Biology is Here
2008	Researchers Tackling Unsolved Questions About Protein Structures
2001	Department of Biochemistry to Hold First Departmental Reunion

Publications (37)

Recent

2015	The Recent De Novo Origin of Protein C-Termini
2015	Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products
2015	Studying protein fold evolution with hybrids of differently folded homologs
2015	Variable Substrate Preference Among Phospholipase D Toxins From Sicariid Spiders
2013	A role for indels in the evolution of Cro protein folds
2013	Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates
2013	A polymetamorphic protein
2012	The porous borders of the protein world
2011	Measuring sup 1 /sup H sup N /sup temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy
2011	Determinants of gas-phase disassembly behavior in homodimeric protein complexes with related yet divergent structures
2011	Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences
2011	Reengineering Cro protein functional specificity with an evolutionary code
2010	A simple method for measuring signs of 1HN chemical shift differences between ground and excited protein states
2009	Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms
2008	Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA
2008	Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds
2008	Structural features and the persistence of acquired proteins
2008	N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces
2007	Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage λ
2006	Relationship between sequence determinants of stability for two natural homologous proteins with different folds
2006	Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria
2006	A trade between similar but nonequivalent intrasubunit and intersubunit contacts in Cro dimer evolution
2006	High polar content of long buried blocks of sequence in protein domains suggests selection against amyloidogenic non-polar sequences
2005	Sequence determinants of a conformational switch in a protein structure
2005	Networking at the Protein Society symposium.
2005	Sphingomyelinase D from venoms of Loxosceles spiders: Evolutionary insights from cDNA sequences and gene structure
2005	Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition
2004	Secondary structure switching in Cro protein evolution
2003	Solution structure of switch Arc, a mutant with 3 sub 10 /sub helices replacing a wild-type β-ribbon
2003	Retroevolution of lambda Cro toward a stable monomer
2000	An evolutionary bridge to a new protein fold
1999	Evolution of a protein fold in vitro
1999	Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions
1996	Sequence space, folding and protein design
1996	Medium effects on the rates of stereomutation of a pair of diastereomeric cyclopropanones. Ground state stabilization in nucleophilic solvents induces deviation from solvent polarity controlled behavior
1994	Stereochemistry of a cyclopropanone by crystal structure analysis. The exo configuration of the diels-alder adduct of cyclopropenone and 1,3-diphenylisobenzofuran appears to be stabilized relative to the endo by an attractive ether-carbonyl interaction
1985	Inhibition of rabbit lung angiotensin-converting enzyme by N(α)-[(S)-1-carboxy-3-phenylpropyl]L-alanyl-L-proline and N(α)-[(S)-1-carboxy-3-phenylpropyl]L-lysyl-L-proline

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