INVESTIGATING TDP-43-MEDIATED TRANSLATIONAL REPRESSION IN MOTOR NEURONS IN A DROSOPHILA MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

EVALUATING NOVEL THERAPIES FOR NEURODEGENERATIVE DISEASES USING DROSOPHILA MODELS

Intrinsic Local Balancing of Hydrophobic and Hydrophilic Residues in Folded Protein Sequences

Mechanisms and Consequences of Evolving a New Protein Fold

A Reduction in Structural Specificity by Polar-to-Hydrophobic Surface Substitutions in the Arc Repressor Protein: A Romance of Three Folds

Birth of a New Protein: How Evolution Does More Than Tinker

Spider Venom Reveals New Secret

BIO5 Institute Funds Eight Collaborative Pilot Grants

The Age of Biology is Here

Researchers Tackling Unsolved Questions About Protein Structures

Studying protein fold evolution with hybrids of differently folded homologs

Variable Substrate Preference Among Phospholipase D Toxins From Sicariid Spiders

Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products

The Recent De Novo Origin of Protein C-Termini

A polymetamorphic protein

A role for indels in the evolution of Cro protein folds

Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphates

The porous borders of the protein world

Evolutionary bridges to new protein folds: design of C-terminal Cro protein chameleon sequences

Determinants of gas-phase disassembly behavior in homodimeric protein complexes with related yet divergent structures

Reengineering Cro protein functional specificity with an evolutionary code

Measuring su1 suH suN su temperature coefficients in invisible protein states by relaxation dispersion NMR spectroscopy

A simple method for measuring signs of 1HN chemical shift differences between ground and excited protein states

Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms

Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA

N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces

Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

Structural features and the persistence of acquired proteins

Conservation and diversity in the immunity regions of wild phages with the immunity specificity of phage 955;

A trade between similar but nonequivalent intrasubunit and intersubunit contacts in Cro dimer evolution

Lateral gene transfer of a dermonecrotic toxin between spiders and bacteria

High polar content of long buried blocks of sequence in protein domains suggests selection against amyloidogenic non-polar sequences

Relationshibetween sequence determinants of stability for two natural homologous proteins with different folds

Sphingomyelinase D from venoms of Loxosceles spiders: Evolutionary insights from cDNA sequences and gene structure

Sequence determinants of a conformational switch in a protein structure

Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition

Networking at the Protein Society symposium.

Secondary structure switching in Cro protein evolution

Retroevolution of lambda Cro toward a stable monomer

Solution structure of switch Arc, a mutant with 3 sub 10 sub helices replacing a wild-type 946;ribbon

An evolutionary bridge to a new protein fold

Evolution of a protein fold in vitro

Tolerance of a protein to multiple polar-to-hydrophobic surface substitutions

Medium effects on the rates of stereomutation of a pair of diastereomeric cyclopropanones. Ground state stabilization in nucleophilic solvents induces deviation from solvent polarity controlled behavior

Sequence space, folding and protein design

Stereochemistry of a cyclopropanone by crystal structure analysis. The exo configuration of the diels-alder adduct of cyclopropenone and 1,3-diphenylisobenzofuran appears to be stabilized relative to the endo by an attractive ether-carbonyl interaction