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Courses
  • IMCAM
    Introduction to Microbiome Community Analysis Methods

Grants
  • Funding agency logo
    AZ-IG ? Neuroinflammation-Induced Pediatric Neuropsychiatric Illness: From Mechanism to Translation

    Principal Investigator (PI)

    2023

    $750.0K
    Active
  • Funding agency logo
    Development of Novel Serological Diagnostic Tool for Children's Postinfectious Autoimmune Encephalopathy (CPAE)

    Key Personnel (KP)

    2023

    $224.9K
    Active
  • Funding agency logo
    The Role of Milk Fat Globule Membrane and 2'-Fucosyllactose in the Infant Gut Microbiota

    undefined (CD)

    2022

    $368.2K
    Active
  • Funding agency logo
    (LTW) Novel Therapeutic Delivery System for Pediatric IBD

    Co-Investigator (COI)

    2022

    $130.0K
    Active
  • Funding agency logo
    Microbiome and Nutrition in Severe PARDS

    Co-Investigator (COI)

    2021

    $1.4M
    Active
  • Funding agency logo
    Impact of IVIG Therapy on Gut and Upper Airway Microbiome and the Associated Immune Response in Children?s Postinfectious Autoimmune Encephalopathy (CPAE)

    Co-Investigator (COI)

    2021

    $500.0K
    Active
  • Funding agency logo
    (SRA) Non-Canonical Roles of NHE3 in the Colonic Epithelium

    Principal Investigator (PI)

    2021

    $347.4K
    Active
  • Funding agency logo
    Exposures, Health Impacts, and Risk for Mine Waste Contamination

    Co-Investigator (COI)

    2020

    $8.9M
    Active
  • Funding agency logo
    Intestinal lysozyme controls mucosal immune response to microbiota

    Principal Investigator (PI)

    2019

    $558.3K
    Active
  • Funding agency logo
    Assessing the Causes, Epidemiology and Under-Diagnosis of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) in Arizonans

    Co-Investigator (COI)

    2018

    $750.0K
Technologies / Patents
      News
      • Steele Children’s Research Center Receives $1.73M Grant

        2016

      • 'Molecular Truck' Could Deliver New Treatment

        2015

      • Curcumin Shows Potential to Prevent Colorectal Cancer

        2015

      • UA Discovery Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism

        2014

      • High School Students Participate in UA Institute on 'Medical Ignorance'

        2013

      • UA Steele Center Receives $1.65M to Continue Autoimmune Disease Research

        2012

      • $1M Grant to Expand IBD Study

        2010

      • Curcumin May be Viable Supplement to Treat Inflammatory Bowel Disease

        2009

      • Steele Center Investigators Discover Answers to Deadly Diarrhea

        2008

      • Turmeric Prevents Experimental Rheumatoid Arthritis and Bone Loss

        2006

      Publications (166)
      Recent
      • Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression.

        2022

      • span style= font-size:11pt; Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism /span

        2022

      • Decreased NHE3 expression in colon cancer is associated with DNA damage, increased inflammation and tumor growth

        2022

      • span style= font-size:11pt; Gut microbiota modulates PARP1-driven PARylation to control colonic inflammation /span

        2022

      • Interactive Effect of Combined Intermittent and Sustained Hypoxia and High-Fat Diet on the Colonic Mucosal Microbiome and Host Gene Expression in Mice

        2022

      • Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism.

        2021

      • Dynamics of dark fermentation microbial communities in the light of lactate and butyrate production

        2021

      • Proliferation in the developing intestine is regulated by the endosomal protein Endotubin

        2021

      • Intestinal Regulatory T Cells

        2021

      • Dynamics of Gut Microbiota Recovery after Antibiotic Exposure in Young and Old Mice (A Pilot Study)

        2021

      • Elevating EGFR-MAPK program by a nonconventional Cdc42 enhances intestinal epithelial survival and regeneration

        2020

      • Emerging Roles of Disabled Homolog 2 (DAB2) in Immune Regulation

        2020

      • Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine

        2020

      • Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T-Cell-Induced, and Infectious Colitis in Mice

        2020

      • Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell-Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction

        2020

      • Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells

        2019

      • Role of Lymphatic Deficiency in the Pathogenesis and Progression of Inflammatory Bowel Disease to Colorectal Cancer in an Experimental Mouse Model

        2019

      • Rapid downregulation of DAB2 by toll-like receptor activation contributes to a pro-inflammatory switch in activated dendritic cells.

        2019

      • Total CD3 T Cells Are Necessary and Sufficient to Induce Colitis in Immunodeficient Mice With Dendritic Cell–Specific Deletion of TGFbR2: A Novel IBD Model to Study CD4 and CD8 T-Cell Interaction

        2019

      • ZBTB32 restrains antibody responses to murine cytomegalovirus infections, but not other repetitive challenges

        2019

      • Significance of NF-kappaB signaling and PARP1 activity in the TNF-induced inhibition of PHEX gene expression in human osteoblasts

        2018

      • Microbial dysbiosis associated with impaired intestinal Na/H exchange accelerates and exacerbates colitis in ex-germ free mice

        2018

      • Sexual Dimorphism in the Response to Broad-spectrum Antibiotics During T Cell-mediated Colitis

        2018

      • Decreased Expression of NHE3 in Colon Cancer Epithelium is Associated with DNA Damage, Increased Local Inflammation and Tumor Growth

        2018

      • Sa1671 - Long-Term Reduction of Nhe3 Expression in Colon Cancer Cells Activates Ampk, and Leads to Energy Crisis While Promoting Cell Survival and Proliferation

        2018

      • Transforming Growth Factor Beta Signaling in Dendritic Cells Is Required for Immunotolerance to Sperm in the Epididymis

        2018

      • Su1948 - Dynamics of Gut Microbiome Recovery after Broad-Spectrum Antibiotic Treatment in Young and Old Mice

        2018

      • SLC9 Gene Family: Function, Expression, and Regulation

        2018

      • Tu1823 - Differential Response to Broad-Spectrum Antibiotics by the Gut Microbiota in Male and Female Mice During Colitis

        2018

      • Tu1853 - Downregulation of Disabled Homolog 2 (DAB2) Expression by Microbial Components in Dendritic Cells in Inflammatory Bowel Disease Contributes to Dendritic Cells Function and Intestinal Inflammation

        2018

      • Epithelial NA + /H + Exchange Promotes Homeostasis in the GUT Microbiome and Protects Against the Development of Colitis

        2017

      • Vitamins and Minerals in Inflammatory Bowel Disease

        2017

      • Mucosal Inflammation, not Microbiome, Drives the Development Colorectal Cancer During Colitis-Associated Microbial Dysbiosis

        2017

      • Microbial Dysbiosis Associated with Impaired Intestinal Na+/H+ Exchange Accelerates and Exacerbates Colitis in Gnotobiotic Mice

        2017

      • TGFβ' Signailing in Dendritic Cells is Required for the Maintenance of CD8 + CD103 + Regulatory T Cell Pool

        2017

      • Expression of Cav1.3 calcium channel in the human and mouse colon: post-transcriptional inhibition by IFNγ

        2017

      • Physiology of Intestinal Absorption and Secretion

        2016

      • Transcriptional reprogramming and resistance to colonic mucosal injury in poly (ADP-ribose) polymerase 1 (PARP1) deficient mice

        2016

      • Reduced epithelial Na<sup>+</sup>/H<sup>+</sup>exchange drives gut microbial dysbiosis and promotes inflammatory response in T cell-mediated murine colitis

        2016

      • Reduced Epithelial Na+/H+ Exchange Drives Gut Microbial Dysbiosis and Promotes Inflammatory Response in T Cell-Mediated Murine Colitis

        2016

      • 563 Post Transcriptional Regulation of Colonic Cav1.3 by IFNγ in Colitis: Potential Implications for IBD-Associated Impaired Intestinal Ca2+Absorption and Bone Loss

        2016

      • 542 Intrinsic Effects of Reduced NHE3 Activity in Intestinal Epithelial Cells

        2016

      • Transcriptional Reprogramming and Resistance to Colonic Mucosal Injury in Poly(ADP-ribose) Polymerase 1 (PARP1)-deficient Mice

        2016

      • Pathophysiology of Intestinal Na+/H+ exchange

        2016

      • ROLE OF THE LYMPHATIC SYSTEM IN THE PROGRESSION OF INFLAMMATORY BOWEL DISEASE TO COLORECTAL CANCER IN AN EXPERIMENTAL MOUSE MODEL

        2016

      • Gut microbial dysbiosis may predict diarrhea and fatigue in patients undergoing pelvic cancer radiotherapy: A pilot study

        2015

      • Clinical characteristics associated with postoperative intestinal epithelial barrier dysfunction in children with congenital heart disease

        2015

      • Sa1764 Poly(ADP-ribose) Polymerase 1 (PARP1) Expression in iTreg Plays a Role in the Pathogenesis of Experimental Colitis

        2015

      • Tu1823 Elevated Expression of Colonic CYP3A4 May Be Responsible for Increased Local Vitamin D3 Metabolism in IBD and Experimental Colitis

        2015

      • Sa1765 Role of Poly(ADP-ribose) Polymerase 1 (PARP1) in the Modulation of Neutrophil Function: Relevance in Inflammatory Bowel Diseases

        2015

      • Experimental colitis is associated with transcriptional inhibition of Na&lt;sup&gt;+&lt;/sup&gt;/Ca&lt;sup&gt;2+&lt;/sup&gt; exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules

        2015

      • Mo1775 Colonic Microbiome and Barrier Dysfunction Contribute to Susceptibility to Colitis in NHE3XRag2 Double Knockout Mice

        2015

      • EARLY PARENTERAL NUTRITION IMPROVES INTESTINAL BARRIER FUNCTION: RESULTS FROM A PILOT RCT

        2015

      • Experimental Colitis Is Associated with Transcriptional Inhibition of Na+/Ca2+Exchanger Isoform 1 (NCX1) Expression by Interferon γ in the Renal Distal Convoluted Tubules

        2015

      • T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome

        2015

      • Tu1739 TGF-Beta Signaling in Dendritic Cells Mediates Crosstalk With Other Innate Immune Cells by Inducing the Production of Cytokines Important in Mucosal Protection

        2014

      • Post-Translational Loss of Renal TRPV5 Calcium Channel Expression, Ca2+ Wasting, and Bone Loss in Experimental Colitis

        2014

      • pTyr<sup>421</sup> cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: Involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)

        2014

      • Tu1761 Dramatic Susceptibility to T-Cell Mediated Colitis in RAG2/NHE3 Double Knockout Mice

        2014

      • Mo1720 Relevance of Poly(ADP-ribose) Polymerase 1 (PARP1) in Experimental Colitis

        2014

      • The Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention

        2014

      • Tu1651 Increased Activation of Dendritic Cells Contributes to T-Cell Mediated Colitis but Not Gastritis in DC-TGFBR2 Ko Mice

        2013

      • Sa1841 Antagonism of TGFβ Signaling Pathway in Dendritic Cells by TLR Stimulation Is TRIF-Dependent

        2013

      • Su1135 High Vitamin D Diet Leads to a Paradoxical Decrease of Bone Mineral Density in Adoptive T-Cell Transfer Colitis

        2013

      • Na+-H+ Exchange in Mammalian Digestive Tract

        2013

      • 739 Alteration of the Gut Microbiome in NHE3-Deficient Mice

        2013

      • Rhythmicity of pancreatic secretion in pigs fed ad libitum five days after weaning

        2013

      • High vitamin D<inf>3</inf> diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

        2013

      • Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis

        2013

      • Metabolic bone disease in inflammatory bowel disease

        2012

      • 1058: INTESTINAL INJURY IN CHILDREN AFTER CARDIOPULMONARY BYPASS

        2012

      • Curcumin inhibits interferon-gamma signaling in colonic epithelial cells

        2012

      • Mo1619 Curcumin Reduces Migration of Human Colon Cancer Cells via Modulation of Cortactin Expression

        2012

      • THE EFFECT OF ENTEROSTATIN ON PIG DUODENAL, JEJUNAL AND ILEAL MOTILITY IN-VITRO

        2012

      • Tu1954 The Pathogenic Role of Poly(ADP-ribose) Polymerase 1 (PARP-1) in Experimental Colitis

        2012

      • Small intestinal ion transport

        2012

      • Polyclonal CD4+Foxp3+ Treg cells induce TGFβ-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

        2012

      • Sa1876 Evaluation of Bone Mineral Density in Four Distinct Models of Colitis

        2012

      • Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium

        2012

      • Tu1949 Abrogation of TGF Signaling in Dendritic Cells Leads to Autoimmunity Through Regulatory T Cell Dependent and Independent Mechanisms

        2012

      • Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity

        2012

      • Na+/H+ Exchange in Mammalian Digestive Tract

        2012

      • High vitamin D-3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

        2011

      • Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases

        2011

      • Transcriptional regulation of the rat NHE3 gene - Functional interactions between GATA-5 and Sp family transcription factors

        2011

      • From probiotics to therapeutics: Another step forward?

        2011

      • Role of NHE3 in the Maintenance of Intestinal Barrier Integrity in IL-10-Deficient Mice

        2011

      • Reduced colonic microbial diversity is associated with colitis in NHE3-deficient mice

        2011

      • Renal CA 2+ Wasting in Murine Models of Crohn's Disease is Mediated by Concerted Downregulation of Klotho and TRPV5 in Distal Convoluted Tubules

        2011

      • Cooperative role of NF-κB and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts

        2010

      • Design, Synthesis, and Testing of a Molecular Truck for Colonic Delivery of 5-Aminosalicylic Acid

        2010

      • EFFECTS OF REVERSIBLE COLD VAGAL BLOCKADE AND ATROPINIZATION ON EXOCRINE PANCREATIC FUNCTION DURING LIQUID FOOD-CONSUMPTION IN CALVES

        2010

      • Cooperative Role of NF-kappa B and Poly(ADP-ribose) Polymerase 1 (PARP-1) in the TNF-induced Inhibition of PHEX Expression in Osteoblasts

        2010

      • Curcumin Inhibits IFN-{gamma} Signaling in Colonic Epithelial Cells

        2010

      • Tumor Necrosis Factor and Interferon-γ Down-regulate Klotho in Mice With Colitis

        2010

      • 909 Lack of TGF-Beta Signaling in Dendritic Cells Leads to Systemic Autoimmunity

        2010

      • T1688 NF-κB Signaling Mediates TNFα-Induced Inhibition of Phex Expression

        2009

      • Unraveling the pathophysiology of alcohol-induced thiamin deficiency

        2009

      • Recent advances in the renal-skeletal-gut axis that controls phosphate homeostasis

        2009

      • 279 Changes in Mucosal Homeostasis Leading to Hypersensitivity to Mucosal Injury in NHE3 Knockout Mice

        2009

      • Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation

        2008

      • Epithelial Transport in Inflammatory Bowel Diseases

        2008

      • S1724 Spontaneous Distal Colitis in NHE3-Deficient Mice

        2008

      • 976 Downregulation of Klotho in Experimental Colitis: the Role of TNFα and IFN-γ

        2008

      • Downregulation of Klotho in Experimental Colitis: the Role of TNF alpha; and IFN- gamma;

        2008

      • Molecular mechanism of rat NHE3 gene promoter regulation by sodium butyrate

        2007

      • Modulation of Neutrophil Motility by Curcumin: Implications for Inflammatory Bowel Disease

        2007

      • Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells

        2007

      • 1,25-dihydroxyvitamin D-3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter

        2007

      • Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P-i cotransporter during ontogeny

        2007

      • pTyr(421) Cortactin Is Overexpressed in Colon Cancer and Is Dephosphorylated by Curcumin: Involvement of Non-Receptor Type 1 Protein Tyrosine Phosphatase (PTPN1)

        2006

      • Developmental aspects of pancreatic exocrine secretion at weaning in the pig.

        2006

      • Cardiac glycoside downregulates NHE3 activity and expression in LLC-PK1 cells

        2006

      • Dendritic Cell-Specific Disruption of TGF-beta Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

        2006

      • The Role of TNF{alpha} in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Colitis

        2006

      • NHE3 modulates the severity of colitis in IL-10-deficient mice

        2006

      • The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis

        2006

      • Na+-H+Exchange in Mammalian Digestive Tract

        2006

      • Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells

        2006

      • Apical NA+/H+ exchangers in the mammalian gastrointestinal tract

        2006

      • Effects of Boswellia serrata in mouse models of chemically induced colitis

        2005

      • Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression

        2005

      • POSSIBLE INTEGRATION OF THE ELECTRICAL-ACTIVITY OF THE DUODENUM AND PANCREAS SECRETION THROUGH ENTEROSTATIN

        2005

      • Polyclonal CD4Foxp3 Treg cells induce TGF beta-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome

        2005

      • 1,25-dihydroxyvitamin D3 down-regulation of PHEX gene expression is mediated by apparent repression of a 110 kDa transfactor that binds to a polyadenine element in the promoter

        2004

      • Ion transport in the intestine

        2004

      • Colonic gene expression profile in NHE3-deficient mice: evidence for spontaneous distal colitis

        2003

      • Transcriptional regulation of the rat NHE3 gene. Functional interactions between GATA-5 and Sp family transcription factors

        2003

      • Enteral crude red kidney bean (Phaseolus vulgaris) lectin - Phytohemagglutinin - Induces maturational changes in the enterocyte membrane proteins of suckling rats

        2003

      • Glucocorticoid regulation and glycosylation of mouse intestinal type IIb Na-P(i) cotransporter during ontogeny

        2002

      • mdr1a deficiency corrects sterility in Niemann-Pick C1 protein deficient female mice

        2002

      • APICAL NA(+)/H(+) EXCHANGERS IN THE MAMMALIAN GASTROINTESTINAL TRACT

        2001

      • Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor

        2001

      • Epidermal growth factor regulation of rat NHE2 gene expression

        2001

      • Regulation of the rat NHE3 gene promoter by sodium butyrate

        2001

      • Changes in Mucosal Homeostasis Predispose NHE3 Knockout Mice to Increased Susceptibility to DSS-Induced Epithelial Injury

        2001

      • Ontogeny of glucocorticoid regulation of the intestinal type IIb sodium-phosphate cotrassperter (Ma/Pi-IIb)

        2001

      • EGF regulation of rat intestinal sodium hydrogen exchanger isoform 2 (NHE 2)

        2001

      • Age- and tissue-specific induction of NHE3 by glucocorticoids in the rat small intestine

        2000

      • Molecular cloning and glucocorticoid responsiveness of the murine PHEX gene promoter

        2000

      • Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent

        2000

      • Expression of rat, renal NHE2 and NHE3 during postnatal development

        2000

      • Cholecystokinin-like activity in the duodenal lumen of anaesthetized neonatal calves

        1999

      • Differential regulation of renal sodium-phosphate transporter by glucocorticoids during rat ontogeny

        1999

      • Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection

        1999

      • Characterization of cis-elements required for osmotic response of rat Na(+)/H(+) exchanger-2 (NHE-2) gene

        1999

      • Lack of efficacy of curcumin on neurodegeneration in the mouse model of Niemann-Pick C1

        1999

      • Characterization of the rat intestinal Fc receptor (FcRn) promoter: transcriptional regulation of FcRn gene by the Sp family of transcription factors

        1998

      • Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves

        1998

      • Influence of duodenal infusion of betaine or choline on blood metabolites and duodenal electrical activity in Friesian calves

        1998

      • Influence of duodenal infusion of L-methionine and L-methionine-dl-sulfoxide on amino acid concentration and duodenal electrical activity in Friesian calves

        1997

      • Pancreatic Exocrine Secretion during the First Days after Weaning in Pigs

        1997

      • Kinetics of pancreatic juice secretion in relation to duodenal migrating myoelectric complex in preruminant and ruminant calves fed twice daily

        1997

      • Ontogeny of basolateral membrane sodium-hydrogen exchange (NHE) activity and mRNA expression of NHE-1 and NHE-4 in rat kidney and jejunum

        1997

      • Functional and molecular characterization of NHE3 expression during ontogeny in rat jejunal epithelium

        1997

      • Cholecystokinin-8 and vasoactive intestinal polypeptide stimulate exocrine pancreatic secretion via duodenally mediated mechanisms in the conscious pig

        1996

      • Enteral crude red kidney bean (Phaseolus vulgaris) lectin phytohernagglutinin induces maturational changes in the enterocyte membrane proteins of suckling rats

        1996

      • Effect of neural blockades, gastrointestinal regulatory peptides, and diversion of gastroduodenal contents on periodic pancreatic secretion in the preruminant calf

        1995

      • The effect of enterostatin on pig duodenal, jejunal and ileal motility in vitro

        1995

      • Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated

        1995

      • Possible integration of the electrical activity of the duodenum and pancreas secretion through enterostatin

        1995

      • Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis

        1994

      • Characterization of cis-elements required for osmotic response of rat Na+/H+ exchanger-2 (NHE-2) gene

        1994

      • The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis

        1992

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