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Picture of Sean Limesand

Sean Limesand

Professor, Physiological Sciences - GIDP | Professor, Animal and Comparative Biomedical Sciences | Member of the Graduate Faculty | Professor, BIO5 Institute | Professor, Obstetrics and Gynecology | Director, Agriculture Research Complex

Animal&Biomedical Sciences-Res

Collaboration(16)

Ronald Lynch
Josef Vagner
Fiona McCarthy
Klearchos Papas
Chiu-Hsieh Hsu

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Grants(25)

eNAMPT-Neutralizing Monoclonal Antibody (ALT-100), as a Novel Treatment of Chorioamnionitis
Active·2024·$100K·
External
Principal Investigator (PI)
monoclonal antibodies, chorioamnionitis, treatment, enampt, novel
Reestablishing Muscle Growth in the Growth Restricted Fetal Lamb
Active·2023·$1.4M / $1.8M·
External
Principal Investigator (PI)
fetal development, muscle regeneration, nutrition, animal physiology, growth restriction
The Role of Alpha1-Adrenergic Receptors Promoter Methylation in Cerebral Autoregulation in Fetus
Active·2023·$152.7K / $763.7K·
External
Co-Investigator (COI)
epigenetics, neurodevelopment, cerebrovascular regulation, fetal development, adrenergic receptors
Alpha Adrenergic Methylation and Developmental Maturation of Cerebral Autoregulation in Ovine Preterm Fetus
Active·2023·$30.7K / $153.5K·
External
Co-Investigator (COI)
adrenergic regulation, developmental maturation, cerebral autoregulation, preterm fetus, methylation
Prevention of Placental Insufficiency Improves Beta-Cells Function
Active·2022·$1.1M / $1.4M·
External
Principal Investigator (PI)
placental insufficiency, beta-cells function, prevention, research, pregnancy

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Publications(118)

Recent

Chronic Epinephrine-Induced Endoplasmic Reticulum and Oxidative Stress Impairs Pancreatic β-Cells Function and Fate

2024

endoplasmic reticulum stress, oxidative stress, epinephrine, chronic stress

Blood Transcriptomic Analyses Reveal Functional Pathways Associated with Thermotolerance in Pregnant Ewes Exposed to Environmental Heat Stress

2023

transcriptomic analysis, thermotolerance, environmental heat stress, pregnant ewes, functional pathways

Molecular markers for thermo-tolerance are associated with reproductive and physiological traits in Pelibuey ewes raised in a semiarid environment

2023

molecular markers, thermotolerance, reproductive traits, physiological traits, semiarid environment

Vascular Stem Cells and the Role of B-Raf Kinase in Survival, Proliferation, and Apoptosis

2023

stem cells, cell signaling, vascular biology, apoptosis, kinase signaling

In Vivo Real-Time Study of Drug Effects on Carotid Blood Flow in the Ovine Fetus

2023

pharmacology, fetal physiology, cardiovascular research, animal studies, real-time monitoring

Elevated Norepinephrine Stimulates Adipocyte Hyperplasia in Ovine Fetuses With Placental Insufficiency and IUGR

2023

adipocyte development, placental insufficiency, intrauterine growth restriction, hormonal regulation, fetal programming

Decreased Pyruvate but Not Fatty Acid Driven Mitochondrial Respiration in Skeletal Muscle of Growth Restricted Fetal Sheep

2023

mitochondrial respiration, fetal programming, skeletal muscle metabolism, growth restriction, metabolic adaptation

Sexual dimorphic gene expression profile of perirenal adipose tissue in ovine fetuses with growth restriction

2023

gene expression, adipose tissue, fetal development, growth restriction, sheep

Tissue-specific responses that constrain glucose oxidation and increase lactate production with the severity of hypoxemia in fetal sheep

2022

metabolism, hypoxia, fetal development, tissue-specific responses, lactate production

Hepatic Lipid Accumulation and Dysregulation Associate with Enhanced Reactive Oxygen Species and Pro-Inflammatory Cytokine in Low-Birth-Weight Goats

2022

lipid accumulation, reactive oxygen species, pro-inflammatory cytokine, low birth weight, hepatic dysregulation