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Dr. Vercelli received her MD degree from the University of Florence in 1978 and trained in immunology at Children’s Hospital/Harvard Medical School, where in 1991 she became an Assistant Professor of Pediatrics. In 1999, she moved to the University of Arizona where she currently is a Regents Professor, a Professor of Cellular and Molecular Medicine, the Associate Director of the Asthma and Airway Disease Research Center, and the Director of the Arizona Center for the Biology of Complex Diseases (ABCD).  She is an elected member of the Association of American Physicians (AAP) and from 2005 to 2012 was the Associate Editor for Genetics of The Journal of Allergy and Clinical Immunology.  Dr. Vercelli’s research relies on both human and animal models and focuses on the environmental, genetic and epigenetic mechanisms that regulate allergic inflammation and asthma.Dr. Vercelli has received numerous honors awards.  In 2017 she received the Herbert Pardes Clinical Research Excellence Award from the Clinical Research Forum. In 2018 she became the Secretary General, and in 2022 the Vice-President, of the Collegium Internationale Allergologicum, of which she will become President in 2026. In 2019 she was awarded the Henry and Phyllis Koffler Prize for Research/Scholarship/Creative Activity by the University of Arizona. In 2022 she became a Regents Professor at the University of Arizona and was elected Fellow of the American Association for the Advancement of Science.

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Courses
  • ET
    Environmental Toxicology

  • PCB
    Principles of Cell Biology

Grants
  • Funding agency logo
    Innate Immunity and Viral Infection in Asthma

    Principal Investigator (PI)

    2021

    $2.9M
    Active
  • Funding agency logo
    Binational Early Asthma & Microbiome Study (BEAMS)

    Multiple Principal Investigator (MPI)

    2020

    $9.1M
    Active
  • Funding agency logo
    Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure

    Principal Investigator (PI)

    2019

    $442.8K
    Active
  • Funding agency logo
    Effect of OM-85-BV in an OVA Model of Asthma: A Comprehensive Dose-Response Study

    Principal Investigator (PI)

    2017

    $11.4M
    Active
  • Funding agency logo
    The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)

    undefined (CD)

    2016

    $561.3K
    Active
  • Funding agency logo
    Fungal Asthma and Lung Innate Immunity

    Key Personnel (KP)

    2020

    $2.1M
  • Funding agency logo
    Assessment of the Asthma-Protective Properties of Cow Shed Dust Fractions from Bavarian Farms

    Principal Investigator (PI)

    2018

    $101.1K
  • Funding agency logo
    Collaboration Agreement to Explore Appropriate and Novel Approaches for the Advancement of OM-85-BV or BronchoVaxom

    Co-Investigator (COI)

    2018

    $8.1K
  • Funding agency logo
    Interactions Between the Environmental Microbiome, Maternal Immunity, Neonatal Epigenome and Respiratory Microbiome Development as Determinants of Asthma in Childhood

    Principal Investigator (PI)

    2017

    $438.7K
  • Funding agency logo
    Effect of OM-85-BV in an OVA Model of Asthma: A Comprehensive Dose-Response Study

    Principal Investigator (PI)

    2016

    $440.6K
Technologies / Patents
      News
      • Five UArizona researchers named AAAS Fellows

        2023

      • ABOR votes to confirm 5 new UArizona Regents Professors

        2022

      • Respiratory Tract Bacterial Extracts Could Prevent COVID-19

        2021

      • Breathing New Life Into the Study of Asthma

        2016

      • Amish Farms May Protect Children Against Asthma

        2016

      • Dusty Secrets Could Help Asthma Sufferers

        2015

      • UA Science Lecture Series: Genomics Now

        2013

      • BIO5 Institute Funds Eight Collaborative Pilot Grants

        2012

      • UA Center Receives Nearly $1 Million from NIH

        2010

      • Researchers to Study How Dogs Decrease Asthma Susceptibility

        2009

      • UA Co-Hosting Conference on Health Disparities

        2009

      • Graduate Council Awards UA Genetics Student $12,000 Fellowship

        2004

      • IBSB Plans May Research Symposium

        2004

      • Public Invited to UA Mini-Medical School Evening Lecture Series

        2003

      • Arizona Respiratory Center Receives Nearly $7 Million NIH SCOR Grant for Study of Asthma

        2002

      • Arizona Respiratory Center Sponsors NIH Program on Lung Disease Genetics

        2002

      • People And Programs On The Move at AHSC

        2001

      • Nationally Recognized Arizona Respiratory Center Campaigns Against Asthma

        2001

      Publications (68)
      Recent
      • Secretory protein beta-lactoglobulin in cattle stable dust may contribute to the allergy-protective farm effect.

        2022

      • Type-2 Cytokine Mitigates Inflammatory Response to SARS-CoV-2

        2022

      • The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression.

        2022

      • The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review

        2022

      • Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development

        2022

      • Microbiota and human allergic diseases: the company we keep

        2021

      • Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis

        2021

      • Asthma- and allergy-protective agents in dust extracts from traditional farm environments

        2021

      • Microbiota, Epigenetics and Trained Immunity: Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood

        2021

      • Completing the hygiene hypothesis: secretory protein beta-lactoglobulin in stable dust may contribute to the allergy protective effect of cattle farms

        2021

      • Maternal prenatal immunity, neonatal immune training, and early airway microbiota development shape the trajectory to childhood asthma

        2021

      • The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression

        2021

      • The Role of Innate Immunity in Asthma Development and Protection: Lessons from the Environment

        2020

      • Intra-Nasal Administration of the OM-85 Bacterial Lysate Strongly Protects from Experimental Asthma by Targeting Multiple Innate and Adaptive Immune Processes

        2020

      • Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells

        2020

      • Strength in numbers: The quest for asthma genes

        2019

      • T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children

        2019

      • Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma

        2018

      • Gut microbiota from Amish but not Hutterite pre-school children protect germ-free mice from experimental asthma

        2018

      • Are We What Our Mothers Made Us? Lessons from Epigenetics

        2017

      • The neonatal methylome as a gatekeeper in the trajectory to childhood asthma

        2017

      • When Innate Responses Matter: ILC2s Loom Large in Allergic Airway Inflammation

        2017

      • Immune development and environment: lessons from Amish and Hutterite children

        2017

      • Prevalence of Asthma in School Children on the Arizona-Sonora Border

        2017

      • The role of ST2 and ST2 genetic variants in schistosomiasis

        2017

      • Innate Immunity and Asthma Risk

        2016

      • A Virtuous Duplicity: 17q21 Variants at the Intersection between Asthma Protection and Risk

        2016

      • Exploration of Early-Life Candidate Biomarkers for Childhood Asthma Using Antibody Arrays

        2016

      • Does epigenetics play a role in human asthma?

        2016

      • Epigenetic Mechanisms in Asthma

        2016

      • Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma

        2016

      • Epigenetics and the trajectory to asthma

        2016

      • Differential regulation of human and mouse IL33 expression in the lungs of human em IL33 /em BAC transgenic mice.

        2016

      • Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

        2016

      • The role of ST2 and ST2 variants in schistosomiasis

        2016

      • A virtuous duplicity: 17q21 variants at the intersection between asthma protection and risk. Editorial

        2016

      • The farm effect and allergic rhinitis

        2015

      • Epigenetics in allergic diseases

        2015

      • An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum

        2015

      • Early predictors of asthma and allergy in children: the role of epigenetics

        2015

      • Environmental protection from allergic diseases: From humans to mice and back

        2015

      • Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment

        2015

      • Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor

        2014

      • Asthma/allergy-associated single nucleotide polymorphisms (SNPs) in IL13 strongly dysregulate human IL4 expression and IgE production

        2013

      • Validation of an Early Life Candidate Biomarker for Childhood Asthma

        2013

      • Epigenetics of human asthma and allergy: promises to keep

        2013

      • Asthma

        2013

      • Discovery of Early Life Plasma Protein Signatures for Asthma Development

        2012

      • The farm effect, or: when, what and how a farming environment protects from asthma and allergic disease

        2012

      • Gene-environment interactions in human disease: nuisance or opportunity?

        2011

      • A SOCS-1 promoter variant is associated with total serum IgE levels

        2011

      • Key advances in mechanisms of asthma, allergy, and immunology in 2009

        2010

      • Environmental determinants of and impact on childhood asthma by the bacterial community in household dust

        2010

      • Genetics and biology of asthma 2010: La' ci darem la mano..

        2010

      • Gene-environment interactions in asthma and allergy: the end of the beginning?

        2010

      • Faithful epigenetic and transcriptional regulation of a transgenic human Th2 cytokine gene locus in the murine nuclear environment (51.1)

        2010

      • NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells

        2010

      • Farm living: effects on childhood asthma and allergy

        2010

      • Of flaky tails and itchy skin

        2009

      • An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression

        2009

      • Phylogenetic and Functional Analysis Identifies Ets-1 as a Novel Regulator of the Th2 Cytokine Gene Locus

        2009

      • NF90 and NF45 Regulate Interleukin‐13 (IL13) Gene Transcription in Human T Cells

        2008

      • Discovering susceptibility genes for asthma and allergy

        2008

      • Advances in asthma and allergy genetics in 2007

        2008

      • Phylogenetic and Functional Analyses Identify Ets‐1 as an Important Regulator of the Th2 Cytokine Gene Locus

        2008

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