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Dr. Vercelli received her MD degree from the University of Florence in 1978 and trained in immunology at Children’s Hospital/Harvard Medical School, where in 1991 she became an Assistant Professor of Pediatrics. In 1999, she moved to the University of Arizona where she currently is a Regents Professor, a Professor of Cellular and Molecular Medicine, the Associate Director of the Asthma and Airway Disease Research Center, and the Director of the Arizona Center for the Biology of Complex Diseases (ABCD). She is an elected member of the Association of American Physicians (AAP) and from 2005 to 2012 was the Associate Editor for Genetics of The Journal of Allergy and Clinical Immunology. Dr. Vercelli’s research relies on both human and animal models and focuses on the environmental, genetic and epigenetic mechanisms that regulate allergic inflammation and asthma.Dr. Vercelli has received numerous honors awards. In 2017 she received the Herbert Pardes Clinical Research Excellence Award from the Clinical Research Forum. In 2018 she became the Secretary General, and in 2022 the Vice-President, of the Collegium Internationale Allergologicum, of which she will become President in 2026. In 2019 she was awarded the Henry and Phyllis Koffler Prize for Research/Scholarship/Creative Activity by the University of Arizona. In 2022 she became a Regents Professor at the University of Arizona and was elected Fellow of the American Association for the Advancement of Science.Show Less
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Courses
- ETEnvironmental Toxicology
- PCBPrinciples of Cell Biology
Grants
- Innate Immunity and Viral Infection in Asthma
Principal Investigator (PI)
2021
$2.9M
Active - Binational Early Asthma & Microbiome Study (BEAMS)
Multiple Principal Investigator (MPI)
2020
$9.1M
Active - Role of Gamma delta-17 T Cells in Asthma Protection by Amish Farm Exposure
Principal Investigator (PI)
2019
$442.8K
Active - Effect of OM-85-BV in an OVA Model of Asthma: A Comprehensive Dose-Response Study
Principal Investigator (PI)
2017
$11.4M
Active - The Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC)
undefined (CD)
2016
$561.3K
Active - Fungal Asthma and Lung Innate Immunity
Key Personnel (KP)
2020
$2.1M
- Assessment of the Asthma-Protective Properties of Cow Shed Dust Fractions from Bavarian Farms
Principal Investigator (PI)
2018
$101.1K
- Collaboration Agreement to Explore Appropriate and Novel Approaches for the Advancement of OM-85-BV or BronchoVaxom
Co-Investigator (COI)
2018
$8.1K
- Interactions Between the Environmental Microbiome, Maternal Immunity, Neonatal Epigenome and Respiratory Microbiome Development as Determinants of Asthma in Childhood
Principal Investigator (PI)
2017
$438.7K
- Effect of OM-85-BV in an OVA Model of Asthma: A Comprehensive Dose-Response Study
Principal Investigator (PI)
2016
$440.6K
Technologies / Patents
News
- Five UArizona researchers named AAAS Fellows
2023
- ABOR votes to confirm 5 new UArizona Regents Professors
2022
- Respiratory Tract Bacterial Extracts Could Prevent COVID-19
2021
- Breathing New Life Into the Study of Asthma
2016
- Amish Farms May Protect Children Against Asthma
2016
- Dusty Secrets Could Help Asthma Sufferers
2015
- UA Science Lecture Series: Genomics Now
2013
- BIO5 Institute Funds Eight Collaborative Pilot Grants
2012
- UA Center Receives Nearly $1 Million from NIH
2010
- Researchers to Study How Dogs Decrease Asthma Susceptibility
2009
- UA Co-Hosting Conference on Health Disparities
2009
- Graduate Council Awards UA Genetics Student $12,000 Fellowship
2004
- IBSB Plans May Research Symposium
2004
- Public Invited to UA Mini-Medical School Evening Lecture Series
2003
- Arizona Respiratory Center Receives Nearly $7 Million NIH SCOR Grant for Study of Asthma
2002
- Arizona Respiratory Center Sponsors NIH Program on Lung Disease Genetics
2002
- People And Programs On The Move at AHSC
2001
- Nationally Recognized Arizona Respiratory Center Campaigns Against Asthma
2001
Publications (68)
Recent
- Secretory protein beta-lactoglobulin in cattle stable dust may contribute to the allergy-protective farm effect.
2022
- Type-2 Cytokine Mitigates Inflammatory Response to SARS-CoV-2
2022
- The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression.
2022
- The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review
2022
- Maternal prenatal immunity, neonatal trained immunity, and early airway microbiota shape childhood asthma development
2022
- Microbiota and human allergic diseases: the company we keep
2021
- Airway administration of OM-85, a bacterial lysate, blocks experimental asthma by targeting dendritic cells and the epithelium/IL-33/ILC2 axis
2021
- Asthma- and allergy-protective agents in dust extracts from traditional farm environments
2021
- Microbiota, Epigenetics and Trained Immunity: Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood
2021
- Completing the hygiene hypothesis: secretory protein beta-lactoglobulin in stable dust may contribute to the allergy protective effect of cattle farms
2021
- Maternal prenatal immunity, neonatal immune training, and early airway microbiota development shape the trajectory to childhood asthma
2021
- The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression
2021
- The Role of Innate Immunity in Asthma Development and Protection: Lessons from the Environment
2020
- Intra-Nasal Administration of the OM-85 Bacterial Lysate Strongly Protects from Experimental Asthma by Targeting Multiple Innate and Adaptive Immune Processes
2020
- Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells
2020
- Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age
2020
- Strength in numbers: The quest for asthma genes
2019
- T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children
2019
- Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma
2018
- Of pleiotropy and trajectories: Does the TGF-β pathway link childhood asthma and chronic obstructive pulmonary disease?
2018
- Gut microbiota from Amish but not Hutterite pre-school children protect germ-free mice from experimental asthma
2018
- Are We What Our Mothers Made Us? Lessons from Epigenetics
2017
- The neonatal methylome as a gatekeeper in the trajectory to childhood asthma
2017
- When Innate Responses Matter: ILC2s Loom Large in Allergic Airway Inflammation
2017
- Immune development and environment: lessons from Amish and Hutterite children
2017
- Prevalence of Asthma in School Children on the Arizona-Sonora Border
2017
- Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers
2017
- The role of ST2 and ST2 genetic variants in schistosomiasis
2017
- Innate Immunity and Asthma Risk
2016
- A Virtuous Duplicity: 17q21 Variants at the Intersection between Asthma Protection and Risk
2016
- Exploration of Early-Life Candidate Biomarkers for Childhood Asthma Using Antibody Arrays
2016
- Does epigenetics play a role in human asthma?
2016
- Epigenetic Mechanisms in Asthma
2016
- Amish and Hutterite Environmental Farm Products Have Opposite Effects on Experimental Models of Asthma
2016
- Epigenetics and the trajectory to asthma
2016
- Differential regulation of human and mouse IL33 expression in the lungs of human em IL33 /em BAC transgenic mice.
2016
- Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children
2016
- The role of ST2 and ST2 variants in schistosomiasis
2016
- A virtuous duplicity: 17q21 variants at the intersection between asthma protection and risk. Editorial
2016
- The farm effect and allergic rhinitis
2015
- Epigenetics in allergic diseases
2015
- An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum
2015
- Early predictors of asthma and allergy in children: the role of epigenetics
2015
- Environmental protection from allergic diseases: From humans to mice and back
2015
- Editorial overview: Allergy and hypersensitivity: New developments in allergy and type 2 immunity: never a dull moment
2015
- Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor
2014
- Asthma/allergy-associated single nucleotide polymorphisms (SNPs) in IL13 strongly dysregulate human IL4 expression and IgE production
2013
- Validation of an Early Life Candidate Biomarker for Childhood Asthma
2013
- Epigenetics of human asthma and allergy: promises to keep
2013
- Asthma
2013
- Discovery of Early Life Plasma Protein Signatures for Asthma Development
2012
- The farm effect, or: when, what and how a farming environment protects from asthma and allergic disease
2012
- Gene-environment interactions in human disease: nuisance or opportunity?
2011
- A SOCS-1 promoter variant is associated with total serum IgE levels
2011
- Key advances in mechanisms of asthma, allergy, and immunology in 2009
2010
- Environmental determinants of and impact on childhood asthma by the bacterial community in household dust
2010
- Genetics and biology of asthma 2010: La' ci darem la mano..
2010
- Gene-environment interactions in asthma and allergy: the end of the beginning?
2010
- Faithful epigenetic and transcriptional regulation of a transgenic human Th2 cytokine gene locus in the murine nuclear environment (51.1)
2010
- NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells
2010
- Farm living: effects on childhood asthma and allergy
2010
- Of flaky tails and itchy skin
2009
- An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression
2009
- Phylogenetic and Functional Analysis Identifies Ets-1 as a Novel Regulator of the Th2 Cytokine Gene Locus
2009
- NF90 and NF45 Regulate Interleukin‐13 (IL13) Gene Transcription in Human T Cells
2008
- Discovering susceptibility genes for asthma and allergy
2008
- Advances in asthma and allergy genetics in 2007
2008
- Phylogenetic and Functional Analyses Identify Ets‐1 as an Important Regulator of the Th2 Cytokine Gene Locus
2008
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