Profile

Brett Colson

Associate Professor, Biomedical Engineering | Associate Professor, BIO5 Institute | Associate Professor, Clinical Translational Sciences | Associate Professor, Cellular and Molecular Medicine | Associate Professor, Biomedical Engineering | Member of the Graduate Faculty | Associate Professor, Physiological Sciences - GIDP

Cellular & Molecular Medicine

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Overview

Research

Collaboration(12)

Page 1 of 3

Grants(17)

Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation
Active·2024·$574.4K / $638.2K·
External
Principal Investigator (PI)
cardiac, myosin, protein, structural dynamics, regulation
Computer Modeling of Myosin Binding Protein C and Its Effects on Cardiac Contraction
Active·2024·$126.8K·
External
Principal Investigator (PI)
computational modeling, cardiac contraction, myosin-binding protein, protein function, cardiovascular physiology
Titin-Based Stiffness Regulation and Mechanosensing in Activated Skeletal Muscle.
Active·2023·$63.2K / $1.3M·
External
Co-Investigator (COI)
muscle mechanics, mechanosensing, skeletal muscle, regulation, titin
Role of Titin in the Pathophysiology of Diaphragm Weakness During Mechanical
Active·2023·$57.2K / $1.1M·
External
Co-Investigator (COI)
muscle biology, respiratory physiology, mechanical ventilation, protein function, pathophysiology
Mapping the Structure and Interaction of Mybp-c and Myosin in Hypertrophic Cardiomyopathy
Active·2023·$0 / $65.1K·
External
Co-Investigator (COI)
cardiomyopathy, protein interaction, muscle structure, hypertrophic, molecular biology

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Publications(56)

Recent

Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations

2024

cardiac myosin-binding protein c, myosin interactions, actin filaments, phosphorylation effects, m-domain mutations

Biosensor for detecting structural changes in human cardiac muscle protein

2024

biosensors, cardiac muscle, protein detection, structural changes, human health

Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin

2023

drug discovery, heart failure, myosin binding protein-c, actin interactions, cardiovascular research

Cardiac myosin-binding protein C N-terminal domains differentially affect calcium dissociation from the cardiac thin filament

2023

cardiac muscle, protein function, calcium regulation, myosin-binding protein, filament structure

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

2023

fluorescence lifetime, cardiac muscle, structural changes, contractile regulation, assay

Compositions and methods to quantify the binding interactions of myosin binding-protein c mybp-c)

2023

protein interactions, biochemistry, molecular biology, biophysics, medical research

Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

2022

cardiac disease, protein dynamics, phosphorylation, mutation, fret

Mapping the binding interaction of MyBP-C and myosin in hypertrophic cardiomyopathy

2022

protein interaction, hypertrophic cardiomyopathy, myosin, mybp-c, mapping

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

2022

protein interactions, cardiac muscle, biophysical studies, molecular dynamics, actin filament

Thick and thin filament effectors of cardiac myofibril contraction detected in a troponin c-based high-throughput fluorescence lifetime assay

2022

cardiac muscle contraction, troponin c, filament effectors, fluorescence assay, myofibril

People

Profile

Brett Colson

Collaboration(12)

Julie Ledford

Marvin Slepian

Hendrikus Granzier

Samantha Harris

Steven Schwartz

Grants(17)

Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation

Computer Modeling of Myosin Binding Protein C and Its Effects on Cardiac Contraction

Titin-Based Stiffness Regulation and Mechanosensing in Activated Skeletal Muscle.

Role of Titin in the Pathophysiology of Diaphragm Weakness During Mechanical

Mapping the Structure and Interaction of Mybp-c and Myosin in Hypertrophic Cardiomyopathy

Publications(56)

Cardiac myosin-binding protein C N-terminal interactions with myosin and actin filaments: Opposite effects of phosphorylation and M-domain mutations

Biosensor for detecting structural changes in human cardiac muscle protein

Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin

Cardiac myosin-binding protein C N-terminal domains differentially affect calcium dissociation from the cardiac thin filament

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation

Compositions and methods to quantify the binding interactions of myosin binding-protein c mybp-c)

Human cardiac myosin-binding protein C phosphorylation- and mutation-dependent structural dynamics monitored by time-resolved FRET

Mapping the binding interaction of MyBP-C and myosin in hypertrophic cardiomyopathy

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

Thick and thin filament effectors of cardiac myofibril contraction detected in a troponin c-based high-throughput fluorescence lifetime assay