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Qing-Yu Zhang

Member of the Graduate Faculty | Professor, Pharmacology and Toxicology

Pharmacology and Toxicology
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30+ Collaborators
$3.4M / $23.2M Funding
10+ Grants
80+ Publications
4+ Courses

About

Qing-Yu Zhang, PhD and professor, Department of Pharmacology and Toxicology—studies the function of intestinal P450 enzymes in drug metabolism and safety. Her research investigates the effects of physiological, pathological and environmental factors on drug bioavailability and chemical toxicity, providing strategies to improve therapeutics and prevent diseases. She is a member of the SOUTHWEST ENVIRNOMENTAL HEALTH SCIENCES CENTER.

Research Area

drug metabolism, toxicology, cytochrome p450, drug development, metabolism, mouse model, mechanisms, toxicity, antiviral, gene expression, xenobiotic metabolism, mouse models, drug repurposing, ionic liquids, naphthalene, lung

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    Recent

    Selective Elimination of Senescent Cancer Cells by Galacto-Modified PROTACs

    2024
    cancer, senescence, drug development, cellular senescence, targeted therapy

    Detection of Transgene Location in the CYP2A13/2B6/2F1-transgenic Mouse Model using Optical Genome Mapping Technology

    2022

    Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites.

    2021

    The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity.

    2021

    The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene.

    2020

    Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung.

    2020
    pulmonary toxicity, cyp enzymes, naphthalene exposure, airway epithelial injury, lung bioactivation

    Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

    2020
    drug metabolism, inflammatory bowel disease, gene expression, mouse model, drug disposition

    Investigation on Pneumotoxicity Induced by Pyrrolizidine AlkaloidsInvestigation on Pneumotoxicity Induced by Pyrrolizidine Alkaloids

    2020

    Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase

    2020
    nephrotoxicity, drug metabolism, mouse models, cytochrome p450, renal tubular injury

    JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo.

    2020
    pharmacokinetics, niclosamide, zika virus, antiviral, drug development

    • Teshia Solomon

    • Jefferey Burgess

    • Wei Wang

    • Nathan Cherrington

    • Brian Mckay

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    • Clinical Pathophysiology II

    • Drug Metabolism and Disposition

    • Introduction to Molecular Therapeutics and Drug Discovery

    • Introduction to Pharmacology and Toxicology Research

    • Drug Disposition and Metabolism

    Qing-Yu Zhang | KMap Profile - Institutional Knowledge Map (KMap)