Picture of Qing-Yu Zhang

Qing-Yu Zhang

Member of the Graduate Faculty | Professor, Pharmacology and Toxicology

Pharmacology and Toxicology

30+ Collaborators

$3.4M / $23M Funding

40+ Publications

About

Qing-Yu Zhang, PhD and professor, Department of Pharmacology and Toxicology—studies the function of intestinal P450 enzymes in drug metabolism and safety. Her research investigates the effects of physiological, pathological and environmental factors on drug bioavailability and chemical toxicity, providing strategies to improve therapeutics and prevent diseases. She is a member of the SOUTHWEST ENVIRNOMENTAL HEALTH SCIENCES CENTER.

Research Area

drug metabolism, toxicology, cytochrome p450, metabolism, drug development, mouse model, mechanisms, antiviral, toxicity, gene expression, xenobiotic metabolism, mouse models, drug repurposing, ionic liquids, naphthalene, lung

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Recent

Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung.

2020

pulmonary toxicity, cyp enzymes, naphthalene exposure, airway epithelial injury, lung bioactivation

Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

2020

drug metabolism, inflammatory bowel disease, gene expression, mouse model, drug disposition

Generation and characterization of a serum albumin‐humanized mouse model for biomarker discovery

2020

biomarker discovery, mouse model, serum albumin, characterization, generation

Proximal Tubular Vacuolization and Hypersensitivity to Drug-Induced Nephrotoxicity in Male Mice With Decreased Expression of the NADPH-Cytochrome P450 Reductase

2020

nephrotoxicity, drug metabolism, mouse models, cytochrome p450, renal tubular injury

JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo.

2020

pharmacokinetics, niclosamide, zika virus, antiviral, drug development

Generation and characterization of a myeloid cell-specific Cyp19a1 knockout mouse model

2019

genetic engineering, immunology, animal model, endocrinology, cell biology

Toxicokinetic Interaction between Hepatic Disposition and Pulmonary Bioactivation of Inhaled Naphthalene Studied Using Null and CYP2A13/2F1-Humanized Mice with Deficient Hepatic Cytochrome P450 Activity

2019

toxicokinetics, inhalation exposure, hepatic metabolism, pulmonary bioactivation, cytochrome p450

Contributions of Hepatic and Intestinal Metabolism to the Disposition of Niclosamide, a Repurposed Drug with Poor Bioavailability

2019

drug metabolism, bioavailability, drug repurposing, hepatic metabolism, intestinal metabolism

Role of mouse cytochrome P450 enzymes of the CYP2ABFGS subfamilies in the induction of lung inflammation by cigarette smoke exposure

2019

cytochrome p450 enzymes, lung inflammation, cyp2abfgs subfamilies, cigarette smoke exposure, mouse

Regulation of Fgf15 expression in the intestine by glucocorticoid receptor

2019

gene expression, hormone regulation, intestinal biology, glucocorticoid receptor, regulatory mechanism

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Introduction to Pharmacology and Toxicology Research
Drug Metabolism and Disposition
Clinical Pathophysiology II
Drug Disposition and Metabolism
Introduction to Molecular Therapeutics and Drug Discovery