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Konrad Zinsmaier

Professor, Neuroscience - GIDP | Professor, Entomology / Insect Science - GIDP | Professor, Neuroscience | Professor, Physiological Sciences - GIDP | Professor, Molecular and Cellular Biology | Department Head, Neuroscience | Member of the Graduate Faculty

Neuroscience
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20+ Collaborators
$4.1M / $4.3M Funding
8+ Grants
30+ Publications
5+ Courses

About

My laboratory has a long-standing interest in understanding molecular mechanisms that facilitate synaptic function and plasticity, and mechanisms that protect synapses from neurodegeneration. We pursue these goals by undertaking a multidisciplinary approach using genetically modified Drosophila as a model system.

Research Area

neuroscience, cell biology, genetics, molecular biology, neurodegenerative diseases, mitochondrial dynamics, neuronal ceroid lipofuscinosis, biochemistry, mitochondrial transport, axonal transport

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    Recent

    Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSP alpha; mutants causes lipofuscin accumulation

    2022
    protein misfolding, neurodegenerative diseases, molecular chaperones, lipofuscin accumulation, neuronal ceroid lipofuscinosis

    Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.

    2020
    mitochondrial dynamics, peroxisomal dynamics, miro gtpases, mitochondrial coordination, cellular dynamics

    Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.

    2019
    neurotransmitter release, plasticity, ubiquitin ligase, dcaf12, homeostasis

    A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism

    2019
    neuronal ceroid lipofuscinosis, drosophila model, gain of function, hypermorphic mechanism, cln4

    High fidelity cryopreservation and recovery of rodent cortical neurons

    2018
    cryopreservation, neuron recovery, rodent neurons, high fidelity preservation, cortical neurons

    Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS

    2017
    als, synaptic vesicles, hsc70-4, post-transcriptional inhibition, hspa8 expression

    Mitochondria on the Road to Power Axonal Regeneration

    2016
    mitochondria, axon regeneration, cellular energy, neurological regeneration, cellular transport

    Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites

    2015
    mitochondrial transport, gtpase domain, axonal transport, dendritic transport, mitochondrial dynamics

    Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

    2015
    membrane potential, phospholipid dynamics, k-ras signaling, plasma membrane, cell signaling

    TRPV1 channels: not so inactive on the ER

    2014
    ion channels, intracellular signaling, pain perception, cellular physiology, neurobiology

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    • Problem Solving with Genetic Tools

    • Neurogenetics

    • Principles of Cellular and Molecular Neurobiology

    • Molecular Mechanisms of Learning and Memory

    • Methods in Insect Science

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    Konrad Zinsmaier | KMap Profile - Institutional Knowledge Map (KMap)