KMap
My laboratory has a long-standing interest in understanding molecular mechanisms that facilitate synaptic function and plasticity, and mechanisms that protect synapses from neurodegeneration. We pursue these goals by undertaking a multidisciplinary approach using genetically modified Drosophila as a model system.

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Courses
  • MMLM
    Molecular Mechanisms of Learning and Memory

  • PSGT
    Problem Solving with Genetic Tools

  • PCMN
    Principles of Cellular and Molecular Neurobiology

  • MIS
    Methods in Insect Science

  • N
    Neurogenetics

  • LM
    Learning and Memory

Grants
  • Funding agency logo
    Cysteine-String Protein and Neurodegeneration

    Principal Investigator (PI)

    2020

    $422.1K
    Active
  • Funding agency logo
    A Fly Model of Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis (ANCL)

    Principal Investigator (PI)

    2015

    $370.7K
  • Funding agency logo
    2015 Bisgrove Scholar Program

    Co-Investigator (COI)

    2015

    $200.0K
  • Funding agency logo
    Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL

    Principal Investigator (PI)

    2014

    $88.7K
  • Funding agency logo
    Role of Miro Signaling for Axonal Transport of Mitochondria

    Principal Investigator (PI)

    2011

    $1.3M
  • Funding agency logo
    Molecular Mechanisms of Neurotransmitter Release

    Principal Investigator (PI)

    2011

    $600.0K
  • Funding agency logo
    Molecular Mechanisms of Mitochondrial Transport Inaxons and Dendrites

    Principal Investigator (PI)

    2010

    $14.0K
  • Funding agency logo
    Neuronal Role of Lipid Flippases

    Principal Investigator (PI)

    2009

    $151.3K
  • Funding agency logo
    Role of dMiro Signaling for Axonal Transport of Mitochondria

    Principal Investigator (PI)

    2007

    $1.2M
News
  • Nerve Cells' Power Plants Caught In A Traffic Jam

    2005

Publications (39)
Recent
  • Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSP alpha; mutants causes lipofuscin accumulation

    2022

  • Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.

    2020

  • Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.

    2019

  • p A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism /p

    2019

  • High fidelity cryopreservation and recovery of rodent cortical neurons

    2018

  • Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS

    2017

  • Mitochondria on the Road to Power Axonal Regeneration

    2016

  • Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

    2015

  • Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites

    2015

  • The Drosophila melanogaster Phospholipid Flippase dATP8B Is Required for Odorant Receptor Function

    2014

  • PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila

    2014

  • TRPV1 channels: not so inactive on the ER

    2014

  • Memory, synapse stability, and β-adducin

    2011

  • Drosophila Neurobiology: A Laboratory Manual

    2011

  • Cysteine-string protein's neuroprotective role

    2010

  • Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ uptake but exert little influence as Ca2+ buffers at nerve firing rates in situ

    2010

  • Ferrying wingless across the synaptic cleft

    2009

  • Mitochondrial transport dynamics in axons and dendrites

    2009

  • Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport

    2009

  • Genetic modifiers of dFMR1 encode RNA granule components in Drosophila

    2009

  • Effects of imaging conditions on mitochondrial transport and length in larval motor axons of Drosophila

    2008

  • Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction

    2007

  • Synaptic Homeostasis on the Fast Track

    2006

  • Elliot S. Valenstein. The War of the Soups and Sparks: The Discovery of Neurotransmitters and the Dispute over How Nerves Communicate

    2006

  • The multiple functions of cysteine-string protein analyzed at Drosophila nerve terminals

    2005

  • The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses

    2005

  • Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis

    2003

  • Presynaptic regulation of neurotransmission in Drosophila by the G protein-coupled receptor Methuselah

    2002

  • Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo

    2001

  • Molecular chaperones and the regulation of neurotransmitter exocytosis

    2001

  • Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila

    2000

  • Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin

    1999

  • Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis

    1998

  • Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in Drosophila but not for vesicle recycling

    1998

  • Presynaptic dysfunction in Drosophila csp mutants

    1994

  • Paralysis and early death in cysteine string protein mutants of Drosophila

    1994

  • An invertebrate calcium-binding protein of the calbindin subfamily: Protein structure, genomic organization, and expression pattern of the calbindin-32 gene of Drosophila

    1993

  • A Cysteine-String Protein is Expressed in Retina and Brain ofDrosophila

    1990

  • A cysteine-string protein is expressed in retina and brain of Drosophila.

    1990

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