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My laboratory has a long-standing interest in understanding molecular mechanisms that facilitate synaptic function and plasticity, and mechanisms that protect synapses from neurodegeneration. We pursue these goals by undertaking a multidisciplinary approach using genetically modified Drosophila as a model system.Show Less
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Courses
- MMLMMolecular Mechanisms of Learning and Memory
- PSGTProblem Solving with Genetic Tools
- PCMNPrinciples of Cellular and Molecular Neurobiology
- MISMethods in Insect Science
- NNeurogenetics
- LMLearning and Memory
Grants
- Cysteine-String Protein and Neurodegeneration
Principal Investigator (PI)
2020
$422.1K
Active - A Fly Model of Autosomal-Dominant Adult-Onset Neuronal Ceroid Lipofuscinosis (ANCL)
Principal Investigator (PI)
2015
$370.7K
- 2015 Bisgrove Scholar Program
Co-Investigator (COI)
2015
$200.0K
- Roles of the CSPalpha Chaperone Complex in Presynaptic Maintenance and ANCL
Principal Investigator (PI)
2014
$88.7K
- Role of Miro Signaling for Axonal Transport of Mitochondria
Principal Investigator (PI)
2011
$1.3M
- Molecular Mechanisms of Neurotransmitter Release
Principal Investigator (PI)
2011
$600.0K
- Molecular Mechanisms of Mitochondrial Transport Inaxons and Dendrites
Principal Investigator (PI)
2010
$14.0K
- Neuronal Role of Lipid Flippases
Principal Investigator (PI)
2009
$151.3K
- Role of dMiro Signaling for Axonal Transport of Mitochondria
Principal Investigator (PI)
2007
$1.2M
News
- Nerve Cells' Power Plants Caught In A Traffic Jam
2005
Publications (39)
Recent
- Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSP alpha; mutants causes lipofuscin accumulation
2022
- Mitochondrial Miro GTPases coordinate mitochondrial and peroxisomal dynamics.
2020
- Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity.
2019
- p A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism /p
2019
- High fidelity cryopreservation and recovery of rodent cortical neurons
2018
- Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS
2017
- Mitochondria on the Road to Power Axonal Regeneration
2016
- Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling
2015
- Miro's N-terminal GTPase domain is required for transport of mitochondria into axons and dendrites
2015
- The Drosophila melanogaster Phospholipid Flippase dATP8B Is Required for Odorant Receptor Function
2014
- PINK1-mediated phosphorylation of Miro inhibits synaptic growth and protects dopaminergic neurons in Drosophila
2014
- TRPV1 channels: not so inactive on the ER
2014
- Memory, synapse stability, and β-adducin
2011
- Drosophila Neurobiology: A Laboratory Manual
2011
- Cysteine-string protein's neuroprotective role
2010
- Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ uptake but exert little influence as Ca2+ buffers at nerve firing rates in situ
2010
- Ferrying wingless across the synaptic cleft
2009
- Mitochondrial transport dynamics in axons and dendrites
2009
- Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport
2009
- Genetic modifiers of dFMR1 encode RNA granule components in Drosophila
2009
- Effects of imaging conditions on mitochondrial transport and length in larval motor axons of Drosophila
2008
- Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction
2007
- Synaptic Homeostasis on the Fast Track
2006
- Elliot S. Valenstein. The War of the Soups and Sparks: The Discovery of Neurotransmitters and the Dispute over How Nerves Communicate
2006
- The multiple functions of cysteine-string protein analyzed at Drosophila nerve terminals
2005
- The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses
2005
- Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis
2003
- Presynaptic regulation of neurotransmission in Drosophila by the G protein-coupled receptor Methuselah
2002
- Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo
2001
- Molecular chaperones and the regulation of neurotransmitter exocytosis
2001
- Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila
2000
- Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin
1999
- Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis
1998
- Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in Drosophila but not for vesicle recycling
1998
- Presynaptic dysfunction in Drosophila csp mutants
1994
- Paralysis and early death in cysteine string protein mutants of Drosophila
1994
- An invertebrate calcium-binding protein of the calbindin subfamily: Protein structure, genomic organization, and expression pattern of the calbindin-32 gene of Drosophila
1993
- A Cysteine-String Protein is Expressed in Retina and Brain ofDrosophila
1990
- A cysteine-string protein is expressed in retina and brain of Drosophila.
1990