Sirtuin 1 (SIRT1) is a protein that belongs to the sirtuin family of proteins, which are involved in regulating various cellular processes such as metabolism, aging, and stress response. SIRT1 has been extensively studied in the field of aging research, as it is known to play a crucial role in promoting longevity and protecting cells from oxidative stress. Research on SIRT1 has shown that it is a key regulator of various cellular pathways, including those involved in DNA repair, inflammation, and energy metabolism. It has been implicated in a wide range of age-related diseases, such as cancer, neurodegenerative disorders, and metabolic diseases. Furthermore, studies have suggested that activation of SIRT1 through various means, such as calorie restriction or the use of pharmacological compounds, can extend lifespan and improve healthspan in various model organisms. This has led to extensive research efforts to develop SIRT1-targeted therapies for age-related diseases and to explore its potential as a target for anti-aging interventions. Overall, research on SIRT1 continues to be a highly active area of study in the fields of aging, metabolism, and longevity, with the goal of understanding its role in cellular homeostasis and exploring its therapeutic potential in age-related diseases.