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Dr Madhavan is an Associate Professor in the Department of Neurology, and directs a research program that broadly centers on Stem Cell Biology and Regenerative Medicine. The ultimate goal is to use this research to develop rational therapeutic strategies to tackle aging and age-related neurological disorders, such as Alzheimer’s and Parkinson’s Disease.Show Less
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Courses
- PBTRADRDIProblem Based Translational Research in Alzheimer's Disease and Related Dementias I
- RMRegenerative Medicine
- NAHNeurodevelopment in Action: How the brain is built, ages, and responds to disease
- PCMNPrinciples of Cellular and Molecular Neurobiology
Grants
- Neural Stem Cell Mechanisms of Resilience Across the Lifespan
Principal Investigator (PI)
2022
$1.1M
Active - Nonlipogenic ABCA1 Inducers for ADRD
Co-Investigator (COI)
2022
$756.9K
Active - Therapeutic Targeting of 5HT1F Receptor-Mediated Mitochondrial Biogenesis To Address Parkinson?s Disease
Principal Investigator (PI)
2022
$499.9K
Active - Deep phenotyping of PD relevant mitochondrial and autophagic mechanisms in human iPSC-derived neural cells
Principal Investigator (PI)
2022
$499.8K
Active - Development of a Biomarker Platform for Parkinson's Disease Using Patient-Derived Cells
Principal Investigator (PI)
2020
$127.3K
- Rejuvenating the Aging Brain by Improving Stem Cell Function
Principal Investigator (PI)
2014
$223.7K
- Neuromelanin in Circulating Phagocytes May Reveal Early Neurodegeneration in Parkinson's Disease: Validation in the 6-OHDA Lesioned Rat Model
Principal Investigator (PI)
2014
$90.6K
Technologies / Patents
News
- Developing a Diverse Workforce To End the Alzheimer’s Epidemic
2019
- UA Researcher Uses Adult Stem-Cell Technology
2016
- Undergraduate Research Opportunities Abound at UA
2012
Publications (44)
Recent
- Parallel Neurodegenerative Phenotypes in Sporadic Parkinsons Disease Fibroblasts and Midbrain Dopamine Neurons
2023
- Design and Synthesis of Novel Brain Penetrant Glycopeptide Analogues of PACAP with Neuroprotective Potential for Traumatic Brain Injury and Parkinsonism.
2022
- 639 Identification of experimental therapeutics overcoming NRAS-based BRAFi-resistant malignant melanoma targeting brain metastases in a bioluminescent murine model
2022
- α-Syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson's disease
2022
- Mefloquine induces ER stress and apoptosis in BRAFi-resistant A375-BRAFV600E /NRASQ61K malignant melanoma cells targeting intracranial tumors in a bioluminescent murine model.
2022
- Mefloquine induces ER stress and apoptosis in BRAFi‐resistant A375‐BRAFV600E/NRASQ61K malignant melanoma cells targeting intracranial tumors in a …
2022
- Design and synthesis of brain penetrant glycopeptide analogues of PACAP with neuroprotective potential for traumatic brain injury and parkinsonism
2022
- NRF2 loss accentuates parkinsonian pathology and behavioral dysfunction in human α-synuclein overexpressing mice
2021
- Enhanced NRF2 expression mitigates the decline in neural stem cell function during aging
2021
- Biomarker platform for parkinson's disease using patient-derived primary dermal fibroblasts
2021
- An NRF2 perspective on stem cells and ageing
2021
- Redox regulation by NRF2 in aging and disease
2019
- Neural Stem Cell Function During Aging: Critical Periods, Regulation, Therapeutic Opportunities
2019
- A role for Nrf2 expression in defining the aging of hippocampal neural stem cells
2018
- iPSC Technology: Breaking New Ground
2018
- An iPSC-Based Platform for Investigating Idiopathic Parkinson's Disease
2018
- Parkinson’s disease skin fibroblasts display signature alterations in growth, redox homeostasis, mitochondrial function and autophagy
2018
- Small-scale Propagation of Human iPSCs in Serum-free Conditions for Routine Immunocytochemical Characterization
2017
- Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle‐age period
2016
- Neural Stem Cells for Intrinsic Brain Repair in Aging and Neural Degeneration
2016
- Effects of the iron oxide nanoparticle Molday ION Rhodamine B on the viability and regenerative function of neural stem cells: relevance to clinical translation
2016
- Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration
2015
- Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism
2015
- Redox-based regulation of neural stem cell function and Nrf2
2015
- Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system
2015
- Systemic human CD34+ cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration
2015
- Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat
2012
- Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model
2012
- Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease
2012
- Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat
2011
- A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity
2010
- Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss
2010
- Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease
2009
- Synergistic relationships between endogenous and exogenous neural precursor cells in a parkinsonian rat model
2009
- Modeling long-term STN deep brain stimulation in parkinsonian rats
2008
- Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor-modulated antioxidant expression
2008
- CHAPTER III. NEUROPROTECTION FROM OXIDATIVE STRESS IN THE STEM CELL NICHE: CELLULAR NETWORKS AND REGULATION OF ANTIOXIDANT EXPRESSION
2006
- Dynamics of neural stem cell-mediated neuroprotection in the presence of oxidative stress: studies in vitro and in vivo
2006
- CHAPTER II. INCREASED" VIGILANCE" OF ANTIOXIDANT MECHANISMS IN NEURAL STEM CELLS POTENTIATES THEIR CAPABILITY TO RESIST OXIDATIVE STRESS
2006
- Increased “vigilance” of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress
2006
- Grafted neural stem cells shield the host environment from oxidative stress
2005
- 5-hydroxytryptamine 1A receptor activation protects against N-methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures
2003
- 5-Hydroxytryptamine 1A Receptor Activation Protects againstN-Methyl-d-aspartate-Induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures
2003
- 5-HT1A Receptor Activation Protects Against NMDA-induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures
2002