Nebulin is a large protein found in skeletal muscle that plays a crucial role in muscle structure and function. It is mainly located in the thin filaments of sarcomeres, where it helps regulate the length of the thin filaments and is important for muscle contraction. Research on nebulin has focused on understanding its role in muscle development, function, and disease, including muscle disorders such as nemaline myopathy. Studies have also explored the structural and functional properties of nebulin and how mutations in the gene encoding nebulin can lead to muscle weakness and dysfunction. Additionally, researchers are investigating potential therapeutic targets for treating nebulin-related muscle disorders.