My work is focused on understanding the mechanisms underlying actin filament assembly in striated muscle. Precise regulation of actin filament polarity, spacing and length is essential for proper muscle function and its dysregulation results in human myopathies. I'm specifically interested in how actin-binding proteins that reside at the ends of the filament cooperate to regulate its architecture. My research utilizes a combination of cellular, genetic, biochemical, molecular and biomechanical approaches.