IL-18, or Interleukin-18, is a proinflammatory cytokine that plays a key role in the regulation of immune responses and inflammation. It is produced by a variety of cells, including macrophages and dendritic cells, and acts on various immune cells to stimulate the production of other inflammatory cytokines. IL-18 has been implicated in a wide range of inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, and asthma. Research in the field of IL-18 aims to better understand its mechanisms of action, its role in different diseases, and its potential as a therapeutic target for treating inflammatory conditions.