HRD1 is a protein involved in the process of endoplasmic reticulum-associated degradation (ERAD), which is a quality control mechanism in cells to eliminate misfolded or unassembled proteins. HRD1 is an E3 ubiquitin ligase that recognizes and tags these proteins for destruction by the proteasome. Research in the area of HRD1 focuses on understanding its role in protein quality control, cellular homeostasis, and disease pathogenesis. Studies have implicated HRD1 in various cellular processes, including protein folding, ER stress response, and regulation of lipid metabolism. Additionally, dysregulation of HRD1 has been linked to various diseases, such as neurodegenerative disorders, cancer, and metabolic disorders. By studying HRD1, researchers hope to uncover new insights into cellular physiology and identify potential therapeutic targets for treating related diseases.