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Dr. Yitshak Zohar Ph.D., is Professor of Aerospace-Mechanical Engineering, Biomedical Engineering and the BIO5 Institute. He received a B.S. and M.S. from Technion-Israel Institute of Technology and a Ph.D. at the University of Southern California. Dr. Zohar was honored with the Fellow - The American Society of Mechanical Engineers (ASME) in 2003; and in 2007, the University of Arizona Technology Innovation Award. Dr. Zohar's research interests are in understand the process of Cell Receptor and Surface Ligand density effects in dynamic states of adhering circulating tumor cells and the creation of a high performance microsystem for isolating circulating tumor cells. With this mission, Dr. Zohar focuses on the development of micro/nanotechnology and fabrication of microfluidic devices for biochemical/medical applications. He has developed novel surface-chemistry techniques that enable selective manipulation of surface properties of fluidic microchannels and nanoparticles. Further developing in ‘smart’ nanoparticles, with encapsulated anti-cancer drug in their core and targeting ligands on their surface, designed to specifically destroy CTCs in vivo in effort to eradicate the cancer disease is taking place. Other work being performed by the Zohar laboratory includes the controlled dissociation of fresh brain tissue into viable neurons suitable for subsequent cell culture utilizing microfluidic systems; the investigation of pollen-tube/ovule interaction, particularly the attraction and repulsion signaling processes, using a microchannel-based assay; and protein-fiber formation in microfluidic devices.

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Courses
  • NTSF
    Nature of Turbulent Shear Flow

  • M
    Microfluidics

  • IFM
    Introduction to Fluid Mechanics

  • T
    Thermodynamics

Grants
  • Funding agency logo
    Bioengineered Prostate-on Chip: Mechanisms of Stromal Dysregulation in Prostate Cancer

    Multiple Principal Investigator (MPI)

    2021

    $1.4M
    Active
  • Funding agency logo
    The MICELI Aggregometer: A Point-of-Care Platelet Function Analyzer

    Co-Investigator (COI)

    2020

    $135.0K
  • Funding agency logo
    A Microfluidic Ex Vivo Lung Model (MEVL) for Studying Pulmonary Diseases

    Co-Investigator (COI)

    2014

    $750.0K
  • Funding agency logo
    Interdisciplinary Collaborative Research: A High Thoroughput, Quantitative Analysis of Arabidopsis Pollen Tube Guidance

    Co-Investigator (COI)

    2010

    $299.5K
  • Funding agency logo
    Microsystem-based Formation of Recombinant Protein Fibers

    Co-Investigator (COI)

    2009

    $409.6K
  • Funding agency logo
    EAGER: Nanoparticle-Based Integrated Microsystem for Selective Targeting of Bio-Species in Flowing Suspensions

    Principal Investigator (PI)

    2009

    $149.9K
  • Funding agency logo
    Novel Applications of Nanotechnology: Microdevices for Capture and Analytics of Circulating Tumor Cells

    Principal Investigator (PI)

    2008

    $50.0K
  • Funding agency logo
    Innovative Microsystems: Novel; Nanostructures to Capture Circulating Breast Cancer Cells

    Principal Investigator (PI)

    2007

    $438.8K
  • Funding agency logo
    Novel Applications of Nanotechnology: Microdevices for Capture and Analysis of Circulating Tumor Cells

    Principal Investigator (PI)

    2006

    $50.0K
Technologies / Patents
      Books
      • Heat Convection in Micro Ducts

        2003

      News
      • Setting Up a Trap to Capture Cancer Cells

        2005

      Publications (150)
      Recent
      • Application of Microfluidic Systems for Breast Cancer Research.

        2022

      • Pharmacokinetic Analysis of Epithelial/Endothelial Cell Barriers in Microfluidic Bilayer Devices with an Air ndash;Liquid Interface

        2020

      • Pharmacokinetic analysis of epithelial/endothelial cell barriers in microfluidic bilayer devices with an air-liquid interface

        2020

      • A nonlinear two-degree-of-freedom mass-damper-spring model to predict the isolation of circulating tumor cells in microfluidic-elasto-filtration devices

        2019

      • Human stroma and epithelium co-culture in a microfluidic model of a human prostate gland

        2019

      • A nonlinear two-degree-of-freedom mass ndash;damper ndash;spring model to predict the isolation of circulating tumor cells in microfluidic-elasto-filtration devices

        2019

      • Permeability of Epithelial/Endothelial Barriers in Transwells and Microfluidic Bilayer Devices

        2019

      • Convection ndash;diffusion molecular transport in a microfluidic bilayer device with a porous membrane

        2019

      • Development of a microfluidic-based model of a human prostate gland

        2018

      • Characterizing steady molecular transport between a microchannel pair separated by a porous membrane

        2018

      • Characterizing A549 cell line as an epithelial cell monolayer model for pharmacokinetic applications

        2018

      • Protein transport through a separation membrane in a microfluidic device

        2018

      • Application of a microfluidic-based model of a human prostate gland for cancer research

        2018

      • The capillary number effect on cell viability in microfluidic elasto-filtration devices for viable circulating tumor cell isolation

        2017

      • Dissociation of brain tissue into viable single neurons in a microfluidic device.

        2015

      • Specific Interactions Between Functionalised Particles and Circulating Tumour Cells

        2014

      • SOI Technology-based Microfiltration System for Circulating Tumor Cells Isolatio and Enumeration

        2014

      • Isolation of viable cancer cells in antibody-functionalized microfluidic devices

        2014

      • Isolation of circulating tumor cells under hydrodynamic loading using microuidic technology

        2014

      • Engineering Aqueous Fiber Assembly Into Silk-elastin-like Protein Polymers

        2014

      • A microfluidic model for organ-specific extravasation of circulating tumor cells

        2014

      • A microfluidic-based platform for in vitro studies of cell signaling in blood vessels

        2013

      • Quantitative characterization of specific targeting of tumor cells by antibody-functionalized particles

        2013

      • Experimental and theoretical study of hydrodynamic cell lysing of cancer cells in a high-throughput Circular Multi-Channel Microfiltration device

        2013

      • Single-phase liquid flow forced convection under a nearly uniform heat flux boundary condition in microchannels

        2012

      • On the minimum detection limit of circulating tumor cells in an antibody-functionalized microchannel array

        2012

      • Flow-rate dependent capture of circulating tumor cells in bio-functional microchannels

        2012

      • A microsystem-based assay for studying pollen tube guidance in plant reproduction

        2011

      • Design, fabrication and characterization of a thermal microsystem integrated with heaters, pressure and temperature microsensors

        2011

      • Dynamic states of adhering cancer cells under shear flow in an antibody-functionalized microchannel

        2011

      • A high-performance microsystem for isolating viable circulating tumor cells

        2011

      • Functionalization of ceramic liposomal nanoparticles, cerasomes, with antibodies

        2011

      • Cluster formation and growth in microchannel flow of dilute particle suspensions

        2011

      • Particle aggregation rate in a microchannel due to a dilute suspension flow

        2011

      • Cell receptor and surface ligand density effects on dynamic states of adhering circulating tumor cells

        2011

      • Adhesion dynamics of circulating tumor cells under shear flow in a bio-functionalized microchannel

        2011

      • Quantitative specific binding of breast cancer cells in an antibody-functionalized microchamber array

        2010

      • Specific binding of cancer cells using a microchamber array functionalized with antibodies

        2010

      • Kinematics of specifically captured circulating tumor cells in bio-functionalized microchannels

        2010

      • Cluster formation and growth in flow of dilute particle suspension in microchannels

        2009

      • Effects of embedded sub-micron pillar arrays in microfluidic channels on large DNA electrophoresis

        2009

      • Microsystem-based study of pollen-tube attractants secreted by ovules

        2009

      • Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel

        2009

      • Cluster dynamics in flow of suspended particles in microchannels

        2009

      • Welcome address

        2008

      • ATTACHMENT DETACHMENT OF PROSTATE CANCER CELLS IN A MICROFLUIDIC SYSTEM

        2008

      • CLUSTER FORMATION AND EVOLUTION IN PARTICLE-LADEN MICROCHANNEL FLOW

        2008

      • An SU-8 based fluidic immuno-spectroscopic lab-on-a-chip for rapid quantitative detection of biomolecules

        2008

      • Evanescent-wave spectroscopy using an SU-8 waveguide for rapid quantitative detection of biomolecules

        2008

      • Microsystems for UV-visible and X-ray analysis of protein crystals

        2007

      • An integrated floating-electrode electric microgenerator

        2007

      • Two-phase flow oscillations in microchannel convective boiling

        2007

      • The nusselt number in single-phase liquid flow forced convection in microchannels

        2007

      • Pillar size effect on DNA electrophoresis in microchips with sub-micron pillar arrays

        2007

      • Fabrication of microchannels with patterned bio-active layers

        2007

      • Two-Dimensional Analysis of Electrokinetically Driven Out-of-Plane Vortices in a Microchannel Liquid Flow Using Patterned Surface Charge

        2007

      • High-throughput design and fabrication of an integrated microsystem with high aspect-ratio sub-micron pillar arrays for free-solution micro capillary electrophoresis

        2006

      • Self-aligned immobilization of proteins utilizing PEG patterns

        2006

      • In-plane vortex flow in microchannels generated by electroosmosis with patterned surface charge

        2006

      • Low melting point agarose as a protection layer in photolithographic patterning of aligned binary proteins

        2006

      • Two-phase flow in MicroChannel heat sink with nearly uniform heat flux boundary condition

        2006

      • Boundary conditions and integrated sensors in microchannel convective heat transfer

        2006

      • Electrokinetically-driven micro mixer with a novel surface-charge pattern

        2005

      • Fabrication and packaging of an inertia electrical micro-switch using low temperature metal-electroplating technology

        2005

      • Design and implementation of an integrated floating-gate electrostatic power micro-generator

        2005

      • Fluid flows in microchannels with cavities

        2005

      • Effect of sub-micron pillar array on DNA kinetics in a free-solution capillary electrophoresis microsystem

        2005

      • Unsteady in-plane vortex motion in a microchannel liquid flow

        2005

      • Height effect on nucleation-site activity and size-dependent bubble dynamics in microchannel convective boiling

        2005

      • Fabrication and Characterization of an Integrated Thermal Microsystem

        2005

      • Self-aligned immobilization of proteins on silicon dioxide surfaces

        2005

      • High-throughput fabrication of sub-micron pillar arrays for free-solution DNA electrophoresis without e-beam lithography

        2005

      • Size-dependent bubble dynamics in a microchannel heat sink

        2005

      • Fabrication and packaging of inertia micro-switch using low-temperature photo-resist molded metal-electroplating technology

        2004

      • Size-dependent flow separation in microchannels with cavities

        2004

      • Height effect on nucleation-site activity in microchannel convective boiling

        2004

      • Plezoresistive microphone with integrated amplifier realized using metal-induced laterally crystallized polycrystalline silicon

        2004

      • Electrokinetic generation of microvortex patterns in a microchannel liquid flow

        2004

      • Design and characterization of inertia-activated electrical micro-switches fabricated and packaged using low-temperature photoresist molded metal-electroplating technology

        2003

      • Design and characterization of micro-inertia switches fabricated using low-temperature metal-electroplating technology

        2003

      • Fabrication and packaging of inertia microswitch using metal-electroplating technology

        2003

      • Surface-chemistry technology for microfluidics

        2003

      • Parallel and series multiple microchannel systems

        2003

      • Design and fabrication of an integrated microsystem for microcapillary electrophoresis

        2003

      • Integrated micro-heat-pipe fabrication technology

        2003

      • Size and shape effects on two-phase flow patterns in microchannel forced convection boiling

        2003

      • Characterization of an integrated micro heat pipe

        2003

      • Electrically Driven Vortical Motion for Mixing of Liquids in a Microchannel

        2003

      • DNA kinetics in microfabricated devices

        2002

      • Micro flow patterns on demand using surface-chemistry technology

        2002

      • Design, fabrication and characterization of an integrated micro heat pipe

        2002

      • Pressure loss in constriction microchannels

        2002

      • Size and shape effects on two-phase flow instabilities in microchannels

        2002

      • Gas flow in a microdevice with a mixing layer configuration

        2002

      • Residual stress-loaded titanium$ndash$nickel shape-memory alloy thin-film micro-actuators

        2002

      • Subsonic gas flow in a straight and uniform microchannel

        2002

      • Design and fabrication of an integrated programmable floating-gate microphone

        2002

      • Microchannels in series connected via a contraction/expansion section

        2002

      • Hele-Shaw Flow in a Microchannel with Cavities

        2002

      • Metal-induced laterally crystallized polycrystalline silicon for integrated sensor applications

        2001

      • Gas flow in microchannels with bends

        2001

      • Forced Convection Boiling in a Microchannel Heat Sing

        2001

      • Flow separation in constriction microchannels

        2001

      • Two-phase flow boiling in a microchannel heat sink

        2001

      • Non-equilibrium temperature and velocity fields in a microchannel flow using discrete kinetic approach

        2001

      • Pressure losses in microchannels with bends

        2001

      • Instability modes of two-phase flows in a mixing-layer microdevice

        2001

      • Forced convection boiling in a microchannel heat sink

        2001

      • The effects of process-induced stress on the microstructures and the phase transformation characteristics of sputtered titanium-nickel thin-film shape-memory alloys

        2001

      • Metal-induced laterally crystallized polycrystalline silicon for micro-systems: Mechanical and etching characteristics

        2001

      • Effects of Stress Induced by the Underlying Layers on the Micro-Structures and Characteristic Phase Transformation Temperatures of Sputtered TiNi Thin Films

        2001

      • Fabrication and characterization of nickel-induced laterally crystallized polycrystalline silicon piezo-resistive sensors

        2000

      • Transient temperature performance of an integrated micro-thermal system

        2000

      • A Class of Discrete Kinetic Solutions for Non-Boundary-Driven Gas Flow

        2000

      • Gas flow in constriction microdevices

        2000

      • Unsteady characteristics of a thermal microsystem

        2000

      • New polycrystalline silicon technology for integrated sensor applications

        2000

      • Class of discrete kinetic solutions for non-boundary-driven gas flow

        2000

      • Frequency response of TiNi shape memory alloy thin film micro-actuators

        2000

      • Phase change in microchannel heat sink under forced convection boiling

        2000

      • Unsteady wire sweep due to transfer molding in a 160L QFP package

        1999

      • Applications of germanium to low temperature micro-machining

        1999

      • Fabrication and characterization of a microsystem for a micro-scale heat transfer study

        1999

      • Micromachined polycrystalline thin film temperature sensors

        1999

      • Wire Sweep Due to Transfer Molding in a 160L QFP Package under Steady-State Conditions

        1999

      • Germanium as a versatile material for low-temperature micromachining

        1999

      • Micro-channel heat sink with integrated temperature sensors for phase transition study

        1999

      • TiNi shape memory alloy thin film rotating actuator topic D: sensors and actuators

        1999

      • Pregate Oxidation Treatment using Radio Frequency Activated Nitrogen in a Rapid Thermal Reactor

        1999

      • Phase change in microchannel heat sinks with integrated temperature sensors

        1999

      • Integrated micro thermal sensors for local temperature measurements in microsystems

        1999

      • Blister-like local buckling of polysilicon microbeams during wet-release

        1998

      • Non-Equilibrium Sound Propagation in Discrete Velocity Models

        1998

      • Measurements of residual stresses in thin films using micro-rotating-structures

        1998

      • Residual-stress relaxation in polysilicon thin films by high-temperature rapid thermal annealing

        1998

      • Rapid thermal annealing of polysilicon thin films

        1998

      • Buckling of polysilicon microbeams during sacrificial layer removal

        1998

      • Study of flow in a micro channel suspended in vacuum

        1998

      • Suspended microchannel with integrated temperature sensors for high-pressure flow studies

        1998

      • Rapid Thermal Annealing for Residual-Stress Relaxation in Undoped or Doped Polysilicon Thin Films

        1998

      • Buckling Evolution of Microelectromechanical Structures

        1998

      • FEM Simulation of Micro-rotating-structures and Their Applications in Measurement of Residual Stresses in Thin Films

        1997

      • Effects of high-temperature rapid thermal annealing on the residual stress of LPCVD-polysilicon thin films

        1997

      • The PVC technique ndash; a method to estimate the dissipation length scale in turbulent flows

        1997

      • Measurements of Residual Stresses in Low-Stress Silicon Nitride Thin Films Using Micro-Rotating Structures

        1996

      • Dissipation scale and control of fine-scale turbulence in a plane mixing layer

        1996

      • Investigation On Subsurface Damage In Silicon Wafers

        1996

      • Microelectromechanical systems

        1995

      • In situ monitoring and universal modelling of sacrificial PSG etching using hydrofluoric acid

        1993

      • Phase decorrelation of coherent structures in a free shear layer

        1991

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