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Ganga Reddy Velma
Researcher/Scientist III
Pharmacology and Toxicology
Overview
Research
More
Collaboration
(13)
Megha Padi
Mutual work: 1 Proposal﹒1 Grant
Collaboration Details
Fayez Ghishan
Mutual work: 1 Proposal﹒1 Grant
Collaboration Details
Pawel Kiela
Mutual work: 1 Proposal﹒1 Grant
Collaboration Details
Gregory Thatcher
Mutual work: 1 Grant﹒1 Supervisor﹒5 Proposals
Collaboration Details
Yana Zavros
Mutual work: 1 Grant﹒1 Proposal
Collaboration Details
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Grants
(1)
PARP1 and PARylation as Novel Effectors of Gut Inflammation
Active
·
2023
·
$0 / $1.2M
·
External
inflammation,
parp1,
gut,
parylation,
effectors
Publications
(38)
Recent
Synthesis and biological evaluation of 1-phenyl-4, 6-dihydrobenzo b] pyrazolo 3, 4-d] azepin-5 1H)one/thiones as anticancer agents
2023
medicinal chemistry,
cancer therapeutics,
organic synthesis,
pharmacology,
drug discovery
Selective non-lipogenic ABCA1 inducer, CL2-57, affects cholesterol efflux pathways and adrenocortical cancer cell migration in 2D and 3D spheroid models
2023
cholesterol efflux,
adrenocortical cancer,
abc transporter,
cell migration,
spheroid models
Synthesis, Optimization, and Structure–Activity Relationships of Nicotinamide Phosphoribosyltransferase NAMPT) Positive Allosteric Modulators N-PAMs)
2023
drug discovery,
enzyme modulators,
chemical synthesis,
enzyme inhibition,
molecular biology
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+
2023
enzyme modulation,
cellular metabolism,
allosteric regulation,
nad+ biosynthesis,
molecular biology
Compounds, compositions, and methods for treating type 2 diabetes and dementia
2022
diabetes,
dementia,
compound,
treatment,
method
Dinuclear orthometallated gold(I)gold(III) anticancer complexes with potent in vivo activity through an ROS-dependent mechanism
2021
anticancer,
gold complexes,
ros-dependent mechanism,
in vivo activity,
metal-based drugs
4beta-amidotriazole linked podophyllotoxin derivatives as potential anticancer agents
2021
anticancer agents,
podophyllotoxin derivatives,
4beta-amidotriazole,
linked derivatives,
anticancer research
Cinnamide derived pyrimidine-benzimidazole hybrids as tubulin inhibitors: Synthesis, in silico and cell growth inhibition studies
2021
tubulin inhibitors,
in silico,
cell growth inhibition,
hybrid synthesis,
pyrimidine-benzimidazole
Identification and characterization of in vitro and in vivo fidarestat metabolites: Toxicity and efficacy evaluation of metabolites
2021
drug metabolism,
toxicity evaluation,
efficacy evaluation,
pharmacokinetics,
drug safety
Conversion of alkynes into 1, 2-diketones using HFIP as sacrificial hydrogen donor and DMSO as dihydroxylating agent
2020
organic chemistry,
chemical engineering,
catalysis,
synthetic chemistry,
organic synthesis