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My laboratory seeks to understand the neural mechanisms that control learning, decision making, and navigation. We also explore how the neural systems involved in these processes become disrupted in Parkinson’s disease, chronic pain, and aging. To further these research objectives, my colleagues and I develop novel instrumentation for visualizing brain activity, measuring dopamine release, controlling experiments, and quantifying behavior.Show Less
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Courses
- PMSPsychological Measurement and Statistics
- NEMCMBNeural Encoding, Memory, and Computation in the Mammalian Brain
- DBDrugs and the Brain
- SNSystems Neuroscience
- SFStatistics Fundamentals
- DBBDrugs, Brain and Behavior
- BCBrain and Cognition
Grants
- Frontal and Temporal Lobe Interactions in Rat Models of Normative Aging and Alzheimer's Disease
Co-Investigator (COI)
2023
$2.2M
Active - Arizona Alzheimer's Consortium Match Projects
Co-Investigator (COI)
2022
$350.0K
Active - The Center of Excellence in Addiction Studies (CEAS)
Co-Investigator (COI)
2021
$2.6M
Active - Control of the Time Course of Dopamine Release Through Optimized Electrical Brain Stimulation
Principal Investigator (PI)
2021
$1.1M
Active - Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
Co-Investigator (COI)
2021
$778.9K
Active - Alpha-Synuclein Driven Cellular Changes and Vocal Dysfunction in Parkinson's Disease
Co-Investigator (COI)
2021
$415.5K
Active - 4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents
Co-Investigator (COI)
2020
$2.1M
Active - Arizona Alzheimer's Consortium Match Projects
Co-Investigator (COI)
2021
$350.0K
- 4D Transcranial Acoustoelectric Imaging for High Resolution Functional Mapping of Neuronal Currents
Co-Investigator (COI)
2019
$428.3K
- Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
Co-Investigator (COI)
2019
$385.1K
News
- Four Questions: Chronic Pain and How It Affects the Brain
2018
- Naps Hinder Learning in Children With Down Syndrome
2018
- Could Limiting Naps Support Learning in Children With Down Syndrome?
2017
- UA Researchers Develop Brain-Mapping Technology
2015
- Two UA Scientists Give Extra Thought to the Brain
2014
Publications (54)
Recent
- Association Between Responsiveness to Transcranial Magnetic Stimulation and Interhemispheric Functional Connectivity of Sensorimotor Cortex in Older Adults
2022
- Aged rats exhibit altered behavior-induced oscillatory activity, place cell firing rates, and spatial information content in the CA1 region of the hippocampus
2022
- Heterogeneous neuronal activity in the ventral tegmental area coordinates dopamine release in the nucleus accumbens
2022
- Interhemispheric functional connectivity of sensorimotor cortex predicts responsiveness of transcranial magnetic stimulation in older adults
2021
- Spectral signatures of L-DOPA-induced dyskinesia depend on L-DOPA dose and are suppressed by ketamine
2021
- Early Intervention via Stimulation of the Medial Septal Nucleus Improves Cognition and Alters Markers of Epileptogenesis in Pilocarpine-Induced Epilepsy
2021
- Activation of hippocampal CA2 precedes CA3 following perforant-path stimulation and spontaneous dentate spikes.
2020
- Moving Fast-Scan Cyclic Voltammetry toward FDA Compliance with Capacitive Decoupling Patient Protection
2020
- Recovery of Theta Frequency Oscillations in Rats Following Lateral Fluid Percussion Corresponds With a Mild Cognitive Phenotype
2020
- Spectral Signatures of L-DOPA-Induced Dyskinesia Depend on L-DOPA Dose and are Suppressed by Ketamine.
2020
- INVESTIGATING MOTOR LEARNING IN A LRRK2 MOUSE MODEL OF PARKINSON’S DISEASE
2020
- Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease.
2020
- Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia
2020
- Mitigating the effects of electrode biofouling-induced impedance for improved long-term electrochemical measurements in vivo
2020
- Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.
2019
- Development of a mobile platform for acoustoelectric brain imaging in rats
2018
- Differential release of dopamine in the nucleus accumbens evoked by low-versus high-frequency medial prefrontal cortex stimulation
2018
- Age‐associated changes in waking hippocampal sharp‐wave ripples
2018
- Ten-hour exposure to low-dose ketamine enhances corticostriatal cross-frequency coupling and hippocampal broad-band gamma oscillations
2018
- Ten-Hour Exposure to Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Broad-Band Gamma Oscillations in the Hippocampus.
2018
- Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats
2018
- Fast, accurate, and low-cost sensing of reward consumption and lick responses in rodents
2018
- REM sleep in naps differentially relates to memory consolidation in typical preschoolers and children with Down syndrome
2018
- Spontaneous Alternation: A Gateway to Spatial Working Memory in Drosophila? Learning and Memory
2017
- Platform to Enable Combined Measurement of Dopamine and Neural Activity
2017
- To Nap or Not to Nap?: Sleep-dependent Memory Consolidation in Typical and Atypically Developing Preschoolers.
2017
- Extended exposure to ketamine reduces cortico-striatal coupling in the beta-band and enhances gamma-band activity in the hippocampus
2017
- Modulation of high-frequency oscillations and beta coherence in striato-cortico-limbic circuits following repeated sub-anesthetic ketamine exposure
2017
- Sleep spindles and fragmented sleep as prodromal markers in LRRK2 G2019S Parkinson’s disease
2017
- Increased cortical spindle power in a LRRK2 mouse model of Parkinson’s Disease
2017
- Nucleus accumbens dopamine release evoked by stimulation of the medial prefrontal cortex peaks at 20 Hz at long stimulation durations
2017
- 0205 TO NAP OR NOT TO NAP? SLEEP-DEPENDENT MEMORY CONSOLIDATION IN TYPICALLY AND ATYPICALLY DEVELOPING PRESCHOOLERS
2017
- Mechanisms of sub-anesthetic ketamine infusions to reduce L-DOPA-induced dyskinesia: effects on striatal mTOR signaling and beta band oscillations in striatum and motor cortex
2017
- Deficits in Instrumental Learning, Persistence, and Cognitive Flexibility in Rats with Neuropathic Pain
2017
- Spontaneous alternation: a potential gateway to spatial working memory in Drosophila
2017
- Neuroplastic mechanism of sub-anesthetic ketamine treatment to reduce development of L-DOPA-induced dyskinesia
2017
- Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain
2016
- Age is associated with reduced sharp-wave ripple frequency and altered patterns of neuronal variability
2016
- Preclinical evaluation of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesias: Is it a'chemical'DBS?
2016
- Repeating firing fields of CA1 neurons shift forward in response to increasing angular velocity
2014
- Intersection of effort and risk: ethological and neurobiological perspectives
2013
- Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences
2012
- Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences (vol 107, pg 2393, 2012)
2012
- " Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences" Corrigendum.
2012
- Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action 1 sequences 2 3 Stephen L. Cowen, Glen A. Davis, Douglas A. Nitz 4 5
2012
- Head direction cells
2009
- Crossing borders: sleep reactivation as a window on cell assembly formation
2008
- Selective delay activity in the medial prefrontal cortex: The contribution of sensory-motor information and expectation
2007
- Selective delay activity in the medial prefrontal cortex of the rat: contribution of sensorimotor information and contingency
2007
- Organization of hippocampal cell assemblies based on theta phase precession
2006
- Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cells
2006
- Firing rate modulation: a simple statistical view of memory trace reactivation
2005
- Off-line reprocessing of recent memory and its role in memory consolidation: a progress report
2003
- Sleep and brain plasticity
2003