KMap

Jon Njardarson

Member of the Graduate Faculty,

Professor, BIO5 Institute,

Professor, Chemistry and Biochemistry-Sci,

Chemistry & Biochemistry - Sci
njardars@arizona.edu

520/626-0754

Grant: $7.3M

Jon Njardarson experts in organic chemistry, bioinformatics, inorganic chemistry, computational biology, organometallic chemistry, medicinal chemistry, catalysis, organic synthesis, chemistry, machine learning, pharmacology, biomaterials, tissue engineering, regenerative medicine, organometallics, bioinorganic chemistry, chemical biology, psychiatry, genomics, nanomaterials, plasmonics, heterogeneous catalysis, materials science, molecular biology, pharmacoepidemiology, polymer chemistry, drug discovery, pharmaceutics, drug delivery, molecular imaging, positron emission tomography, synthetic biology, crystallography, supramolecular chemistry, synthetic organic chemistry, entomology, insecticide resistance, health economics, health services research, biochemistry, nanotechnology, biostatistics, clinical trials, neuropharmacology, neuroprotection, analytical chemistry, pharmacokinetics

Courses

Advanced Organic Synthesis

Advanced Synthetic Organic Chemistry

Lectures in Organic Chemistry

Recent Grants

	2022	$525.0K	Active
Anionic and Pericyclic Reaction Cascades for Organic Synthesis
	2022	$83.0K	Active
Novel Small Molecules with Neuroprotective Potential in ALS: a "Fly-To-Human" Approach
	2021	$1.9M	Active
DMREF: Computational Chemistry to Accelerate Development of Long Wave Infrared Polymers
$Logo of MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education funding agency$	2021	$266.2K	Active
MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
$Logo of Hoya 167 High Refractive Index Polymers for Consumer Plastic Eye-Wear from Elemental Sulfur funding agency$	2021	$114.3K	Active
Hoya 167 High Refractive Index Polymers for Consumer Plastic Eye-Wear from Elemental Sulfur
	2019	$561.8K	Active
New Reaction Cascades for Organic Synthesis
	2022	$678.6K
Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-To-Human' Approach
	2019	$500.8K
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
	2017	$110.0K
Development of an Aromatic C-H Bond Substitution Approach
	2016	$545.7K
New Class of Anionic Cascades Reactions for Organic Synthesis

Technologies / Patents

	2021	Neuroprotective Compounds and Methods of Use
	2019	Tricyclic Mosquitocides and Methods of Making and Using Thereof
	2019	[3+2] Annulation to Produce 5-Membered Heterocyclic Compounds
	1899	Tricyclic Mosquitocides and Methods of Making and Using Thereof

News

2015	Diversifying the Workforce for Tomorrow's Jobs
2014	FDA-approved Drug Database Created by UA Professor Being Used Globally
2011	UA Faculty, Staff Developing Mobile Apps

Publications (144)

Recent

2023	One Step Selective Counterion Dependent Formation of Conjugated Chiral N-Sulfinylimines from Aldehydes
2022	Phenols in pharmaceuticals: analysis of a recurring motif
2022	Nanocomposite particles comprising a boronic acid moiety and methods for producing and using the same
2022	Minimalistic graphical presentation approach for total syntheses
2022	Oxiranes and oxirenes: Monocyclic
2022	Sulfenyl Chlorides: An Alternative Monomer Feedstock from Elemental Sulfur for Polymer Synthesis
2022	Anionic Amino-Cope Rearrangement Cascade Synthesis of 2, 4-Substituted Benzoate Esters from Acyclic Building Blocks
2021	Polymerizations with elemental sulfur: from petroleum refining to polymeric materials
2021	Dramatic Effect of γ-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades
2021	Neuroprotective compounds and methods of use
2021	Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines
2021	Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures
2021	Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures
2020	A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine
2020	Strategic Vinyl Sulfone Nucleophile β-Substitution Significantly Impacts Selectivity in Vinylogous Darzens and Aza-Darzens Reactions
2019	Efforts Toward a Unified Kainoid Family Synthesis Approach: Unexpected Sulfinamide‐Directed Conjugate Addition Results
2019	Single wall nanotube constructs and uses thereof
2019	[3+ 2] annulation to produce 5-membered heterocyclic compounds
2019	Tricyclic mosquitocides and methods of making and using thereof
2019	Analysis of US FDA-approved drugs containing sulfur atoms
2018	Review of synthetic approaches toward maoecrystal V
2018	[2.2. 2]-to [3.2. 1]-bicycle skeletal rearrangement approach to the gibberellin family of natural products
2018	A survey of the structures of US FDA approved combination drugs
2018	Total synthesis of (±)-phomoidride D: A 22 year odyssey
2018	Tunable dimetal tetraguanidinate paddlewheel complexes with unprecedented electron donor abilities
2018	Asymmetric vinylogous aza-Darzens approach to vinyl aziridines
2018	Total Synthesis of (±)‐Phomoidride D
2018	From oxiranes to oligomers: Architectures of US FDA approved pharmaceuticals containing oxygen heterocycles
2018	Correction to “New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures”
2017	Dearomatization approach to 2-trifluoromethylated benzofuran and dihydrobenzofuran products
2017	New class of anion-accelerated amino-Cope rearrangements as gateway to diverse chiral structures
2017	New Class of Anion-Accelerated Amino-Cope Rearrangement as Gateway to Diverse Chiral Structures
2017	Novel architectures that exhibit potent and selective inhibition of protein tyrosine phosphatases implicated in cancers and metabolic disease
2017	Novel synthesis of fluorinated indoles and benzofurans via oxidative dearomatization
2017	Double-Diels-Alder Approach to Maeocrystal V. Unexpected C-C Bond Forming Fragmentations of the [2.2.2]-Bicyclic Core
2017	Tunable catalysis with dimetal tetraguanidinate paddlewheel complexes
2017	Efforts towards the total synthesis of maoecrystal V
2017	Asymmetric vinyolgous aza-Darzens approach towards the synthesis of vinyl aziridines
2017	Top 200 pharmaceutical products by retail sales in 2016
2016	Method and system for drug design
2016	A Mild meta‐Selective C–H Alkylation of Catechol Mono‐Ethers
2016	Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio‐and Aminophosphate Precursors
2016	Metal‐Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization
2015	Synthetic Approaches and Total Syntheses of Vinigrol, A Unique Diterpenoid
2015	Ring Expansions of Oxiranes and Oxetanes
2015	Asymmetric [3+ 2] Annulation Approach to 3‐Pyrrolines: Concise Total Syntheses of (−)‐Supinidine,(−)‐Isoretronecanol, and (+)‐Elacomine
2015	Formation of Fused Aromatic Architectures via an Oxidative Dearomatization - Radical Cyclization Rearomatization Approach
2015	Formation of fused aromatic architectures via an oxidative dearomatization—radical cyclization rearomatization approach
2015	Synthesis of 1, 2, 3, 6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches
2015	Asymmetric [3+2] Annulation Approach to 3-Pyrrolines. Concise Total Syntheses of (-)-Supinidine, (-)-Isoretronecanol and (+)-Elacomine
2015	The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol
2014	Evolution of an oxidative dearomatization enabled total synthesis of vinigrol
2014	H, O, and N! Analysis of the Elemental Composition of US FDA Approved Drug Architectures Smith, Brandon R.; Eastman, Candice M.; Njardarson, Jon T
2014	Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals
2014	Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective
2014	Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2014	Skalierbare rhodiumkatalysierte intermolekulare Aziridinierungen
2014	Mild stereoselective formation of tri-and tetrasubstituted olefins by regioselective ring opening of 1, 1-disubstituted vinyl oxiranes with dialkyl dithiophosphates
2014	Data-mining for sulfur and fluorine: An evaluation of pharmaceuticals to reveal opportunities for drug design and discovery: Miniperspective
2014	Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures Miniperspective
2014	Z-selective ring opening of vinyl oxetanes/oxiiranes with dialkyl dithiophosphate nucleophiles
2014	A Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction
2013	Ring expansions of vinyloxiranes,-thiiranes, and-aziridines: synthetic approaches, challenges, and catalytic success stories
2013	Base Mediated Deprotection Strategies for Trifluoroethyl Ether (TFEE), a New Alcohol Protecting Group
2013	Recent Advances in the Metal Catalyzed Ring Expansions of Three and Four Membered Rings
2013	Mechanism and the origins of stereospecificity in copper-catalyzed ring expansion of vinyl oxiranes: a traceless dual transition-metal-mediated process
2013	Total Synthesis of Vinigrol
2013	An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History
2013	Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History Ilardi, Elizabeth A.; Vitaku, Edon; Njardarson, Jon T
2013	Top 200 pharmaceutical products by US retail sales in 2012
2013	Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process
2013	Single wall nanotube constructs and uses therefor
2013	Z-Selective ring opening of vinyl oxetanes with dialkyl dithiophosphate nucleophiles
2013	Catalytic ring expansion adventures
2013	Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group
2013	Ring Expansions of Vinyloxiranes, -thiiranes, and -aziridines: Synthetic Approaches, Challenges, and Catalytic Success Stories
2013	Recent advances in the metal-catalyzed ring expansions of three-and four-membered rings
2013	Production of 2, 5-dihydrofurans and analogous compounds
2013	Syntheses and Structural Confirmations of Members of a Heterocycle Containing Family of Labdane Diterpenoids
2013	Asymmetric ring expansion of vinyl oxetanes
2012	Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C–O reduction approach
2012	Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles
2012	New mechanistic insights into the copper catalyzed ring expansion of vinyl aziridines: evidence in support of a copper (i) mediated pathway
2012	Chemistry by design: a web-based educational flashcard for exploring synthetic organic chemistry
2012	Efficient Synthesis of Thiopyrans Using a Sulfur‐Enabled Anionic Cascade
2012	Pharmaceutical structure montages as catalysts for design and discovery
2012	Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes
2012	Catalytic ring expansion of vinyl oxetanes: asymmetric synthesis of dihydropyrans using chiral counterion catalysis
2012	Reactions at your fingertips
2011	Mechanistic studies of the copper-catalyzed rearrangement of vinyl aziridines
2011	Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
2011	Stereospecific ring expansion of chiral vinyl aziridines
2011	Synthetic efforts toward [3.3. 1] bridged bicyclic phloroglucinol natural products pp 7631e7666
2011	Synthetic efforts toward [3.3. 1] bridged bicyclic phloroglucinol natural products
2010	A graphical journey of innovative organic architectures that have improved our lives
2010	The strategic marriage of method and motif. Total synthesis of varitriol
2010	Stereoselective ring expansion of vinyl oxiranes: mechanistic insights and natural product total synthesis
2010	Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims
2010	Copper-Catalyzed Stereoselective Ring Expansion of Vinyl Oxiranes
2010	An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products
2009	6 steps OH
2009	Creative approaches towards the synthesis of 2, 5-dihydro-furans, thiophenes, and pyrroles. One method does not fit all!
2009	The development of new synthetic methods
2009	A Concise Ring‐Expansion Route to the Compact Core of Platensimycin
2009	Thieme Chemistry Journal Awardees-Where are They Now? Efforts towards the Total Synthesis of Vinigrol
2009	An Adler–Becker oxidation approach to vinigrol
2009	Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton
2008	Sigmatropic Rearrangement of Vinyl Aziridines Brichacek, Matthew; Lee, DongEun; Njardarson, Jon T
2008	An Efficient Substrate‐Controlled Approach Towards Hypoestoxide, a Member of a Family of Diterpenoid Natural Products with an Inside‐Out [9.3. 1] Bicyclic Core
2008	Lewis acid catalyzed [1, 3]-sigmatropic rearrangement of vinyl aziridines
2007	Highly selective copper-catalyzed ring expansion of vinyl thiiranes: application to synthesis of biotin and the heterocyclic core of plavix
2007	PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice
2007	Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes
2007	Formal Synthesis of Biotin
2006	Formation of cyclic ethers via an oxonium ylide mediated [2, 3] sigmatropic rearrangement
2006	Copper-catalyzed rearrangement of vinyl oxiranes
2006	ORGN 954-Metal-catalyzed rearrangements of vinyl oxiranes
2006	Migrastatin analogs in the treatment of cancer
2005	The Migrastatins: A new family of metastatasis inhibitors
2005	Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
2004	Migrastatin analog compositions and uses thereof
2004	Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure− activity studies of (+)-migrastatin
2004	The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis
2004	Progress toward the total synthesis of the phomoidrides.
2004	Migrastatin analogs and uses thereof
2003	Vignette 3: Radicicol and the Epothilones: Total Synthesis of Novel Anticancer Agents Using Ring‐Closing Metathesis
2003	Synthesis of epothilones, intermediates thereto and analogues thereof
2003	Application of phenolic oxidation chemistry in synthesis: preparation of the BCE ring system of ryanodine
2003	The total synthesis of (+)-migrastatin
2003	The art of innovation in organic chemistry: Synthetic efforts toward the phomoidrides
2002	Reactive dienes: Intramolecular aromatic oxidation of 3-(2-hydroxyphenyl)-propionic acids
2002	Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl) propionic Acids Drutu, Ioana; Njardarson, Jon T.; Wood, John L
2002	Total syntheses of [17]-and [18] dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: Correlation of ring size with biological activity in the …
2002	Highly concise routes to epothilones: The total synthesis and evaluation of epothilone 490
2002	CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C–H insertion
2002	Synthesis of a fully functionalized isotwistane precursor to the phomoidrides.
2002	Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis
2001	Evolution of a Synthetic Approach to CP-263,114
2001	An expeditious approach toward the total synthesis of CP-263,114
1998	Progress towards the total synthesis of cp-263,114: Methods for constructing the Bicyclic core
1996	Progress towards the total synthesis of CP-263,114
1995	DEVELOPMENT OF A HIGHLY STEREOSELECTIVE TANDEM CLAISEN-ALPHA-KETOL REARRANGEMENT-ASYMMETRIC-SYNTHESIS OF THE K252A SUGAR MOIETY
1995	A Concise Synthetic Route to Pure Isomers of the Antifungal Agents (E)-and (Z)-1, 2-Diaryl-3-(1-imidazolyl)-1-propenes
1994	A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions

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