KMap

Photo of Jon Njardarson(njardars)

Jon Njardarson

Member of the Graduate Faculty,
Professor, BIO5 Institute,
Professor, Chemistry and Biochemistry-Sci,

Chemistry & Biochemistry - Sci
njardars@arizona.edu
520/626-0754
UAVitae logogoogle scholar logoOrcid logo
Grant: $7.3M
Jon Njardarson experts in organic chemistry, bioinformatics, inorganic chemistry, computational biology, organometallic chemistry, medicinal chemistry, catalysis, organic synthesis, chemistry, machine learning, pharmacology, biomaterials, tissue engineering, regenerative medicine, organometallics, bioinorganic chemistry, chemical biology, psychiatry, genomics, nanomaterials, plasmonics, heterogeneous catalysis, materials science, molecular biology, pharmacoepidemiology, polymer chemistry, drug discovery, pharmaceutics, drug delivery, molecular imaging, positron emission tomography, synthetic biology, crystallography, supramolecular chemistry, synthetic organic chemistry, entomology, insecticide resistance, health economics, health services research, biochemistry, nanotechnology, biostatistics, clinical trials, neuropharmacology, neuroprotection, analytical chemistry, pharmacokinetics
Courses
Advanced Organic Synthesis 
Advanced Synthetic Organic Chemistry 
Lectures in Organic Chemistry 
Recent Grants
Logo of Anionic and Pericyclic Reaction Cascades for Organic Synthesis funding agency
2022 $525.0KActive
Anionic and Pericyclic Reaction Cascades for Organic Synthesis
Logo of Novel Small Molecules with Neuroprotective Potential in ALS: a "Fly-To-Human" Approach funding agency
2022 $83.0KActive
Novel Small Molecules with Neuroprotective Potential in ALS: a "Fly-To-Human" Approach
Logo of DMREF: Computational Chemistry to Accelerate Development of Long Wave Infrared Polymers funding agency
2021 $1.9MActive
DMREF: Computational Chemistry to Accelerate Development of Long Wave Infrared Polymers
Logo of MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education funding agency
2021 $266.2KActive
MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
Logo of Hoya 167 High Refractive Index Polymers for Consumer Plastic Eye-Wear from Elemental Sulfur funding agency
2021 $114.3KActive
Hoya 167 High Refractive Index Polymers for Consumer Plastic Eye-Wear from Elemental Sulfur
Logo of New Reaction Cascades for Organic Synthesis funding agency
2019 $561.8KActive
New Reaction Cascades for Organic Synthesis
Logo of Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-To-Human' Approach funding agency
2022 $678.6K
Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-To-Human' Approach
Logo of MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona funding agency
2019 $500.8K
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
Logo of Development of an Aromatic C-H Bond Substitution Approach funding agency
2017 $110.0K
Development of an Aromatic C-H Bond Substitution Approach
Logo of New Class of Anionic Cascades Reactions for Organic Synthesis funding agency
2016 $545.7K
New Class of Anionic Cascades Reactions for Organic Synthesis
Technologies / Patents
Logo of Neuroprotective Compounds and Methods of Use
2021Neuroprotective Compounds and Methods of Use 
Logo of Tricyclic Mosquitocides and Methods of Making and Using Thereof
2019Tricyclic Mosquitocides and Methods of Making and Using Thereof 
Logo of [3+2] Annulation to Produce 5-Membered Heterocyclic Compounds
2019[3+2] Annulation to Produce 5-Membered Heterocyclic Compounds 
Logo of Tricyclic Mosquitocides and Methods of Making and Using Thereof
1899Tricyclic Mosquitocides and Methods of Making and Using Thereof 
News
2015Diversifying the Workforce for Tomorrow's Jobs 
2014FDA-approved Drug Database Created by UA Professor Being Used Globally 
2011UA Faculty, Staff Developing Mobile Apps 
Publications (144)
Recent
2023One Step Selective Counterion Dependent Formation of Conjugated Chiral N-Sulfinylimines from Aldehydes 
2022Phenols in pharmaceuticals: analysis of a recurring motif 
2022Nanocomposite particles comprising a boronic acid moiety and methods for producing and using the same 
2022Minimalistic graphical presentation approach for total syntheses 
2022Oxiranes and oxirenes: Monocyclic 
2022Sulfenyl Chlorides: An Alternative Monomer Feedstock from Elemental Sulfur for Polymer Synthesis 
2022Anionic Amino-Cope Rearrangement Cascade Synthesis of 2, 4-Substituted Benzoate Esters from Acyclic Building Blocks 
2021Polymerizations with elemental sulfur: from petroleum refining to polymeric materials 
2021Dramatic Effect of γ-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades 
2021Neuroprotective compounds and methods of use 
2021Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines 
2021Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures 
2021Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures 
2020A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine 
2020Strategic Vinyl Sulfone Nucleophile β-Substitution Significantly Impacts Selectivity in Vinylogous Darzens and Aza-Darzens Reactions 
2019Efforts Toward a Unified Kainoid Family Synthesis Approach: Unexpected Sulfinamide‐Directed Conjugate Addition Results 
2019Single wall nanotube constructs and uses thereof 
2019[3+ 2] annulation to produce 5-membered heterocyclic compounds 
2019Tricyclic mosquitocides and methods of making and using thereof 
2019Analysis of US FDA-approved drugs containing sulfur atoms 
2018Review of synthetic approaches toward maoecrystal V 
2018[2.2. 2]-to [3.2. 1]-bicycle skeletal rearrangement approach to the gibberellin family of natural products 
2018A survey of the structures of US FDA approved combination drugs 
2018Total synthesis of (±)-phomoidride D: A 22 year odyssey 
2018Tunable dimetal tetraguanidinate paddlewheel complexes with unprecedented electron donor abilities 
2018Asymmetric vinylogous aza-Darzens approach to vinyl aziridines 
2018Total Synthesis of (±)‐Phomoidride D 
2018From oxiranes to oligomers: Architectures of US FDA approved pharmaceuticals containing oxygen heterocycles 
2018Correction to “New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures” 
2017Dearomatization approach to 2-trifluoromethylated benzofuran and dihydrobenzofuran products 
2017New class of anion-accelerated amino-Cope rearrangements as gateway to diverse chiral structures 
2017New Class of Anion-Accelerated Amino-Cope Rearrangement as Gateway to Diverse Chiral Structures 
2017Novel architectures that exhibit potent and selective inhibition of protein tyrosine phosphatases implicated in cancers and metabolic disease 
2017Novel synthesis of fluorinated indoles and benzofurans via oxidative dearomatization 
2017Double-Diels-Alder Approach to Maeocrystal V. Unexpected C-C Bond Forming Fragmentations of the [2.2.2]-Bicyclic Core 
2017Tunable catalysis with dimetal tetraguanidinate paddlewheel complexes 
2017Efforts towards the total synthesis of maoecrystal V 
2017Asymmetric vinyolgous aza-Darzens approach towards the synthesis of vinyl aziridines 
2017Top 200 pharmaceutical products by retail sales in 2016 
2016Method and system for drug design 
2016A Mild meta‐Selective C–H Alkylation of Catechol Mono‐Ethers 
2016Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio‐and Aminophosphate Precursors 
2016Metal‐Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization 
2015Synthetic Approaches and Total Syntheses of Vinigrol, A Unique Diterpenoid 
2015Ring Expansions of Oxiranes and Oxetanes 
2015Asymmetric [3+ 2] Annulation Approach to 3‐Pyrrolines: Concise Total Syntheses of (−)‐Supinidine,(−)‐Isoretronecanol, and (+)‐Elacomine 
2015Formation of Fused Aromatic Architectures via an Oxidative Dearomatization - Radical Cyclization Rearomatization Approach 
2015Formation of fused aromatic architectures via an oxidative dearomatization—radical cyclization rearomatization approach 
2015Synthesis of 1, 2, 3, 6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches 
2015Asymmetric [3+2] Annulation Approach to 3-Pyrrolines. Concise Total Syntheses of (-)-Supinidine, (-)-Isoretronecanol and (+)-Elacomine 
2015The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol 
2014Evolution of an oxidative dearomatization enabled total synthesis of vinigrol 
2014H, O, and N! Analysis of the Elemental Composition of US FDA Approved Drug Architectures Smith, Brandon R.; Eastman, Candice M.; Njardarson, Jon T 
2014Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals 
2014Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective 
2014Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery 
2014Skalierbare rhodiumkatalysierte intermolekulare Aziridinierungen 
2014Mild stereoselective formation of tri-and tetrasubstituted olefins by regioselective ring opening of 1, 1-disubstituted vinyl oxiranes with dialkyl dithiophosphates 
2014Data-mining for sulfur and fluorine: An evaluation of pharmaceuticals to reveal opportunities for drug design and discovery: Miniperspective 
2014Beyond C, H, O, and N! Analysis of the Elemental Composition of U.S. FDA Approved Drug Architectures Miniperspective 
2014Z-selective ring opening of vinyl oxetanes/oxiiranes with dialkyl dithiophosphate nucleophiles 
2014A Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction 
2013Ring expansions of vinyloxiranes,-thiiranes, and-aziridines: synthetic approaches, challenges, and catalytic success stories 
2013Base Mediated Deprotection Strategies for Trifluoroethyl Ether (TFEE), a New Alcohol Protecting Group 
2013Recent Advances in the Metal Catalyzed Ring Expansions of Three and Four Membered Rings 
2013Mechanism and the origins of stereospecificity in copper-catalyzed ring expansion of vinyl oxiranes: a traceless dual transition-metal-mediated process 
2013Total Synthesis of Vinigrol 
2013An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History 
2013Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History Ilardi, Elizabeth A.; Vitaku, Edon; Njardarson, Jon T 
2013Top 200 pharmaceutical products by US retail sales in 2012 
2013Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process 
2013Single wall nanotube constructs and uses therefor 
2013Z-Selective ring opening of vinyl oxetanes with dialkyl dithiophosphate nucleophiles 
2013Catalytic ring expansion adventures 
2013Base mediated deprotection strategies for trifluoroethyl (TFE) ethers, a new alcohol protecting group 
2013Ring Expansions of Vinyloxiranes, -thiiranes, and -aziridines: Synthetic Approaches, Challenges, and Catalytic Success Stories 
2013Recent advances in the metal-catalyzed ring expansions of three-and four-membered rings 
2013Production of 2, 5-dihydrofurans and analogous compounds 
2013Syntheses and Structural Confirmations of Members of a Heterocycle Containing Family of Labdane Diterpenoids 
2013Asymmetric ring expansion of vinyl oxetanes 
2012Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C–O reduction approach 
2012Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles 
2012New mechanistic insights into the copper catalyzed ring expansion of vinyl aziridines: evidence in support of a copper (i) mediated pathway 
2012Chemistry by design: a web-based educational flashcard for exploring synthetic organic chemistry 
2012Efficient Synthesis of Thiopyrans Using a Sulfur‐Enabled Anionic Cascade 
2012Pharmaceutical structure montages as catalysts for design and discovery 
2012Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes 
2012Catalytic ring expansion of vinyl oxetanes: asymmetric synthesis of dihydropyrans using chiral counterion catalysis 
2012Reactions at your fingertips 
2011Mechanistic studies of the copper-catalyzed rearrangement of vinyl aziridines 
2011Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin 
2011Stereospecific ring expansion of chiral vinyl aziridines 
2011Synthetic efforts toward [3.3. 1] bridged bicyclic phloroglucinol natural products pp 7631e7666 
2011Synthetic efforts toward [3.3. 1] bridged bicyclic phloroglucinol natural products 
2010A graphical journey of innovative organic architectures that have improved our lives 
2010The strategic marriage of method and motif. Total synthesis of varitriol 
2010Stereoselective ring expansion of vinyl oxiranes: mechanistic insights and natural product total synthesis 
2010Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims 
2010Copper-Catalyzed Stereoselective Ring Expansion of Vinyl Oxiranes 
2010An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products 
20096 steps OH 
2009Creative approaches towards the synthesis of 2, 5-dihydro-furans, thiophenes, and pyrroles. One method does not fit all! 
2009The development of new synthetic methods 
2009A Concise Ring‐Expansion Route to the Compact Core of Platensimycin 
2009Thieme Chemistry Journal Awardees-Where are They Now? Efforts towards the Total Synthesis of Vinigrol 
2009An Adler–Becker oxidation approach to vinigrol 
2009Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton 
2008Sigmatropic Rearrangement of Vinyl Aziridines Brichacek, Matthew; Lee, DongEun; Njardarson, Jon T 
2008An Efficient Substrate‐Controlled Approach Towards Hypoestoxide, a Member of a Family of Diterpenoid Natural Products with an Inside‐Out [9.3. 1] Bicyclic Core 
2008Lewis acid catalyzed [1, 3]-sigmatropic rearrangement of vinyl aziridines 
2007Highly selective copper-catalyzed ring expansion of vinyl thiiranes: application to synthesis of biotin and the heterocyclic core of plavix 
2007PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice 
2007Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes 
2007Formal Synthesis of Biotin 
2006Formation of cyclic ethers via an oxonium ylide mediated [2, 3] sigmatropic rearrangement 
2006Copper-catalyzed rearrangement of vinyl oxiranes 
2006ORGN 954-Metal-catalyzed rearrangements of vinyl oxiranes 
2006Migrastatin analogs in the treatment of cancer 
2005The Migrastatins: A new family of metastatasis inhibitors 
2005Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice 
2004Migrastatin analog compositions and uses thereof 
2004Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure− activity studies of (+)-migrastatin 
2004The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis 
2004Progress toward the total synthesis of the phomoidrides. 
2004Migrastatin analogs and uses thereof 
2003Vignette 3: Radicicol and the Epothilones: Total Synthesis of Novel Anticancer Agents Using Ring‐Closing Metathesis 
2003Synthesis of epothilones, intermediates thereto and analogues thereof 
2003Application of phenolic oxidation chemistry in synthesis: preparation of the BCE ring system of ryanodine 
2003The total synthesis of (+)-migrastatin 
2003The art of innovation in organic chemistry: Synthetic efforts toward the phomoidrides 
2002Reactive dienes: Intramolecular aromatic oxidation of 3-(2-hydroxyphenyl)-propionic acids 
2002Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl) propionic Acids Drutu, Ioana; Njardarson, Jon T.; Wood, John L 
2002Total syntheses of [17]-and [18] dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: Correlation of ring size with biological activity in the … 
2002Highly concise routes to epothilones: The total synthesis and evaluation of epothilone 490 
2002CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C–H insertion 
2002Synthesis of a fully functionalized isotwistane precursor to the phomoidrides. 
2002Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis 
2001Evolution of a Synthetic Approach to CP-263,114 
2001An expeditious approach toward the total synthesis of CP-263,114 
1998Progress towards the total synthesis of cp-263,114: Methods for constructing the Bicyclic core 
1996Progress towards the total synthesis of CP-263,114 
1995DEVELOPMENT OF A HIGHLY STEREOSELECTIVE TANDEM CLAISEN-ALPHA-KETOL REARRANGEMENT-ASYMMETRIC-SYNTHESIS OF THE K252A SUGAR MOIETY 
1995A Concise Synthetic Route to Pure Isomers of the Antifungal Agents (E)-and (Z)-1, 2-Diaryl-3-(1-imidazolyl)-1-propenes 
1994A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions 
Grants
Citations
H-Index
Tech
Patents
News
Books
Opportunities