Courses
- ASOAdvanced Synthetic Organic Chemistry
- LOCLectures in Organic Chemistry
- AOSAdvanced Organic Synthesis
Student Thesis/Dissertation
- Expansion of the Anionic Amino-Cope Cascade and Deuteration of Monomers for the Creation of Perdeuterated Polymers
2022
doctoral - Analysis of FDA-Approved Drugs and Select Methods Toward Analogs of Cantharidin and Apomorphine
2021
doctoral - Development of New Anionic Cascades and Analysis of US FDA Drug Architectures
2021
doctoral - Development of New Anionic Hopping Cascade Routes to Synthesize Various Heterocycles
2019
doctoral - Development of Oxidative Dearomatization Enabled Methods to Synthesize Various Heterocycles
2019
doctoral - Oxidative Dearomatization / Diels-Alder Approaches to Maoecrystal V and the Gibberellin Family of Natural Products
2018
doctoral - Strategic Oxidative Dearomatization - Rearomatization Cascades in the Synthesis of Aromatic and Heteroaromatic Synthons
2016
doctoral - New Anionic Annulation Reactions and Anion Accelerated Amino-Cope Rearrangement
2016
doctoral - New Ring Expansion and Ring Opening Reactions of Vinyl Oxetanes and Vinyl Oxiranes
2014
doctoral
Grants
- Anionic and Pericyclic Reaction Cascades for Organic Synthesis
Principal Investigator (PI)
2022
$537.8KActive - Novel Small Molecules with Neuroprotective Potential in ALS: a "Fly-To-Human" Approach
Principal Investigator (PI)
2022
$166.0KActive - DMREF: Computational Chemistry to Accelerate Development of Long Wave Infrared Polymers
Co-Investigator (COI)
2021
$1.9MActive - MRI: Acquisition of a Single-Crystal X-Ray Diffractometer for Research and Education
Co-Investigator (COI)
2021
$266.2KActive - Novel Small Molecules with Neuroprotective Potential in ALS: A 'Fly-To-Human' Approach
Co-Investigator (COI)
2022
$678.6K - Hoya 167 High Refractive Index Polymers for Consumer Plastic Eye-Wear from Elemental Sulfur
Co-Investigator (COI)
2021
$114.3K - New Reaction Cascades for Organic Synthesis
Principal Investigator (PI)
2019
$561.8K - MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance Spectrometer for Research and Training at the University of Arizona
Principal Investigator (PI)
2019
$500.8K - Development of an Aromatic C-H Bond Substitution Approach
Principal Investigator (PI)
2017
$110.0K - New Class of Anionic Cascades Reactions for Organic Synthesis
Principal Investigator (PI)
2016
$545.7K
Technologies / Patents
News
- Diversifying the Workforce for Tomorrow's Jobs
2015
- FDA-approved Drug Database Created by UA Professor Being Used Globally
2014
- UA Faculty, Staff Developing Mobile Apps
2011
Publications (132)
Recent
- One SteSelective Counterion Dependent Formation of Conjugated Chiral N-Sulfinylimines from Aldehydes
2023
- Phenols in pharmaceuticals: analysis of a recurring motif
2022
- Minimalistic graphical presentation approach for total syntheses
2022
- Oxiranes and oxirenes: Monocyclic
2022
- Sulfenyl Chlorides: An Alternative Monomer Feedstock from Elemental Sulfur for Polymer Synthesis
2022
- Anionic Amino-Cope Rearrangement Cascade Synthesis of 2, 4-Substituted Benzoate Esters from Acyclic Building Blocks
2022
- Nanocomposite particles comprising a boronic acid moiety and methods for producing and using the same
2022
- Neuroprotective compounds and methods of use
2021
- Polymerizations with elemental sulfur: from petroleum refining to polymeric materials
2021
- Oxidative Route to Indoles via Intramolecular Amino-Hydroxylation of o-Allenyl Anilines
2021
- Dramatic Effect of γ-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades
2021
- Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures
2021
- Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated SCF3) Aziridine and Cyclopropane Structures
2021
- A structural analysis of the FDA green book-approved veterinary drugs and roles in human medicine
2020
- Strategic Vinyl Sulfone Nucleophile β-Substitution Significantly Impacts Selectivity in Vinylogous Darzens and Aza-Darzens Reactions
2020
- Tricyclic mosquitocides and methods of making and using thereof
2019
- Efforts Toward a Unified Kainoid Family Synthesis Approach: Unexpected Sulfinamide‐Directed Conjugate Addition Results
2019
- Analysis of US FDA-approved drugs containing sulfur atoms
2019
- Single wall nanotube constructs and uses thereof
2019
- [3+ 2] annulation to produce 5-membered heterocyclic compounds
2019
- A survey of the structures of US FDA approved combination drugs
2018
- Review of synthetic approaches toward maoecrystal V
2018
- Correction to “New Class of Anion-Accelerated Amino-Cope Rearrangements as Gateway to Diverse Chiral Structures”
2018
- Asymmetric vinylogous aza-Darzens approach to vinyl aziridines
2018
- Total Synthesis of ±)‐Phomoidride D
2018
- From oxiranes to oligomers: Architectures of US FDA approved pharmaceuticals containing oxygen heterocycles
2018
- Total synthesis of ±)phomoidride D: A 22 year odyssey
2018
- [2.2. 2]to 3.2. 1]bicycle skeletal rearrangement approach to the gibberellin family of natural products
2018
- Tunable dimetal tetraguanidinate paddlewheel complexes with unprecedented electron donor abilities
2018
- New Class of Anion-Accelerated Amino-Cope Rearrangement as Gateway to Diverse Chiral Structures
2017
- Tunable catalysis with dimetal tetraguanidinate paddlewheel complexes
2017
- Novel synthesis of fluorinated indoles and benzofurans via oxidative dearomatization
2017
- Double-Diels-Alder Approach to Maeocrystal V. Unexpected C-C Bond Forming Fragmentations of the 2.2.2]Bicyclic Core
2017
- Asymmetric vinyolgous aza-Darzens approach towards the synthesis of vinyl aziridines
2017
- To200 pharmaceutical products by retail sales in 2016
2017
- Efforts towards the total synthesis of maoecrystal V
2017
- Novel architectures that exhibit potent and selective inhibition of protein tyrosine phosphatases implicated in cancers and metabolic disease
2017
- Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products
2017
- Metal‐Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization
2016
- A Mild meta-Selective C–H Alkylation of Catechol Mono-Ethers
2016
- Method and system for drug design
2016
- Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio‐and Aminophosphate Precursors
2016
- Asymmetric 3+2] Annulation Approach to 3-Pyrrolines. Concise Total Syntheses of Supinidine, Isoretronecanol and Elacomine
2015
- Formation of Fused Aromatic Architectures via an Oxidative Dearomatization Radical Cyclization Rearomatization Approach
2015
- Formation of fused aromatic architectures via an oxidative dearomatization—radical cyclization rearomatization approach
2015
- Synthesis of 1, 2, 3, 6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches
2015
- The Realization of an Oxidative Dearomatization–Intramolecular Diels–Alder Route to Vinigrol
2015
- Ring Expansions of Oxiranes and Oxetanes
2015
- Synthetic Approaches and Total Syntheses of Vinigrol, A Unique Diterpenoid
2015
- Z-selective ring opening of vinyl oxetanes/oxiiranes with dialkyl dithiophosphate nucleophiles
2014
- Skalierbare rhodiumkatalysierte intermolekulare Aziridinierungen
2014
- Evolution of an oxidative dearomatization enabled total synthesis of vinigrol
2014
- Mild stereoselective formation of tri-and tetrasubstituted olefins by regioselective ring opening of 1, 1-disubstituted vinyl oxiranes with dialkyl dithiophosphates
2014
- A Scalable Rhodium‐Catalyzed Intermolecular Aziridination Reaction
2014
- Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective
2014
- Data-mining for sulfur and fluorine: An evaluation of pharmaceuticals to reveal opportunities for drug design and discovery: Miniperspective
2014
- Beyond C, H, O, and N! Analysis of the elemental composition of US FDA approved drug architectures: Miniperspective
2014
- H, O, and N! Analysis of the Elemental Composition of US FDA Approved Drug Architectures Smith, Brandon R. Eastman, Candice M. Njardarson, Jon T
2014
- Asymmetric ring expansion of vinyl oxetanes
2013
- Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History Ilardi, Elizabeth A. Vitaku, Edon; Njardarson, Jon T
2013
- Production of 2, 5-dihydrofurans and analogous compounds
2013
- To200 pharmaceutical products by US retail sales in 2012
2013
- Total synthesis of vinigrol
2013
- An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents That Chronicle Our Medicinal History
2013
- Syntheses and Structural Confirmations of Members of a Heterocycle‐Containing Family of Labdane Diterpenoids
2013
- Base mediated deprotection strategies for trifluoroethyl TFE) ethers, a new alcohol protecting group
2013
- Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process
2013
- Single wall nanotube constructs and uses therefor
2013
- Ring expansions of vinyloxiranes,thiiranes, and-aziridines: synthetic approaches, challenges, and catalytic success stories
2013
- Catalytic Ring Expansion Adventures
2013
- Z-Selective ring opening of vinyl oxetanes with dialkyl dithiophosphate nucleophiles
2013
- Recent advances in the metal-catalyzed ring expansions of three-and four-membered rings
2013
- Pharmaceutical structure montages as catalysts for design and discovery
2012
- Reactions at your fingertips
2012
- Chemistry by design: a web-based educational flashcard for exploring synthetic organic chemistry
2012
- Synthesis of allylic and homoallylic alcohols from unsaturated cyclic ethers using a mild and selective C–O reduction approach
2012
- Catalytic ring expansion of vinyl oxetanes: asymmetric synthesis of dihydropyrans using chiral counterion catalysis
2012
- Distinct biological effects of golgicide a derivatives on larval and adult mosquitoes
2012
- Intermolecular oxonium ylide mediated synthesis of medium-sized oxacycles
2012
- New mechanistic insights into the copper catalyzed ring expansion of vinyl aziridines: evidence in support of a copper i) mediated pathway
2012
- Efficient Synthesis of Thiopyrans Using a Sulfur‐Enabled Anionic Cascade
2012
- Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
2011
- Mechanistic studies of the copper-catalyzed rearrangement of vinyl aziridines
2011
- Synthetic efforts toward 3.3. 1] bridged bicyclic phloroglucinol natural products
2011
- Stereospecific ring expansion of chiral vinyl aziridines
2011
- Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims
2010
- An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products
2010
- A graphical journey of innovative organic architectures that have improved our lives
2010
- Copper-Catalyzed Stereoselective Ring Expansion of Vinyl Oxiranes
2010
- The strategic marriage of method and motif. Total synthesis of varitriol
2010
- Stereoselective ring expansion of vinyl oxiranes: mechanistic insights and natural product total synthesis
2010
- Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton
2009
- The development of new synthetic methods
2009
- A Concise Ring‐Expansion Route to the Compact Core of Platensimycin
2009
- An Adler–Becker oxidation approach to vinigrol
2009
- Creative approaches towards the synthesis of 2, 5-dihydro-furans, thiophenes, and pyrroles. One method does not fit all!
2009
- Thieme Chemistry Journal Awardees-Where are They Now? Efforts towards the Total Synthesis of Vinigrol
2008
- Sigmatropic Rearrangement of Vinyl Aziridines Brichacek, Matthew; Lee, DongEun; Njardarson, Jon T
2008
- An Efficient Substrate‐Controlled Approach Towards Hypoestoxide, a Member of a Family of Diterpenoid Natural Products with an Inside‐Out 9.3. 1] Bicyclic Core
2008
- Lewis acid catalyzed 1, 3]sigmatropic rearrangement of vinyl aziridines
2008
- Formal Synthesis of Biotin
2007
- Highly selective copper-catalyzed ring expansion of vinyl thiiranes: application to synthesis of biotin and the heterocyclic core of plavix
2007
- PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice
2007
- Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes
2007
- Formation of cyclic ethers via an oxonium ylide mediated 2, 3] sigmatropic rearrangement
2006
- ORGN 954-Metal-catalyzed rearrangements of vinyl oxiranes
2006
- Migrastatin analogs in the treatment of cancer
2006
- Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
2005
- The Migrastatins: A new family of metastatasis inhibitors
2005
- The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis
2004
- Progress toward the total synthesis of the phomoidrides.
2004
- Discovery of potent cell migration inhibitors through total synthesis: Lessons from structure− activity studies of migrastatin
2004
- Migrastatin analogs and uses thereof
2004
- Vignette 3: Radicicol and the Epothilones: Total Synthesis of Novel Anticancer Agents Using Ring‐Closing Metathesis
2003
- The art of innovation in organic chemistry: Synthetic efforts toward the phomoidrides
2003
- Synthesis of epothilones, intermediates thereto and analogues thereof
2003
- Application of phenolic oxidation chemistry in synthesis: preparation of the BCE ring system of ryanodine
2003
- The total synthesis of migrastatin
2003
- Reactive dienes: Intramolecular aromatic oxidation of 3-2-hydroxyphenyl)propionic acids
2002
- Total syntheses of 17]and 18] dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: Correlation of ring size with biological activity in the …
2002
- Highly concise routes to epothilones: The total synthesis and evaluation of epothilone 490
2002
- Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis
2002
- Intramolecular Aromatic Oxidation of 3-2-Hydroxyphenyl) propionic Acids Drutu, Ioana; Njardarson, Jon T. Wood, John L
2002
- Synthesis of a fully functionalized isotwistane precursor to the phomoidrides.
2002
- CP-263,114 synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C–H insertion
2002
- An expeditious approach toward the total synthesis of CP-263,114
2001
- Evolution of a Synthetic Approach to CP-263,114
2001
- Progress towards the total synthesis of cp-263,114: Methods for constructing the Bicyclic core
1998
- Progress towards the total synthesis of CP-263,114
1996
- DEVELOPMENT OF A HIGHLY STEREOSELECTIVE TANDEM CLAISEN-ALPHA-KETOL REARRANGEMENT-ASYMMETRIC-SYNTHESIS OF THE K252A SUGAR MOIETY
1995
- A Concise Synthetic Route to Pure Isomers of the Antifungal Agents E)and Z)1, 2-Diaryl-3-1-imidazolyl)1-propenes
1995
- A facile synthesis of α-phosphono esters through methoxycarbonylation of α-phosphono carbanions
1994
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