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Photo of M. Leandro Heien(mheien)

M. Leandro Heien

Associate Professor, Chemistry and Biochemistry-Sci,
Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
mheien@arizona.edu
520/621-6293
UAVitae logogoogle scholar logo
Grant: $10.6M
M. Leandro Heien experts in neuroscience, microfluidics, psychiatry, pharmacology, dopamine, biosensors, electrochemistry, mass spectrometry, biomaterials, tissue engineering, bioinformatics, drug delivery, proteomics, drosophila, biostatistics, computational biology, electrocatalysis, nanotechnology, bioelectrochemistry, nanoelectronics, nanofabrication, electroanalytical, addiction, analytical chemistry, neuroimaging, biomems, metabolomics, regenerative medicine, neuroengineering, carbon nanotubes, molecular imaging, neuroendocrinology, exocytosis, cytoskeleton, systems biology, biomedical optics, biophotonics, microelectromechanical systems, mems, computational fluid dynamics, reward, polymer chemistry, materials science, adsorption spectroscopy
Courses
Mass Spectrometry 
Instrumental Analysis 
Analytical Chemistry 
Analytical Separations 
Advanced Analytical Chemistry 
Biochemistry 
Advanced Analytical Chemistry Laboratory 
Recent Grants
Logo of The Center of Excellence in Addiction Studies (CEAS) funding agency
2021 $2.6MActive
The Center of Excellence in Addiction Studies (CEAS)
Logo of Control of the Time Course of Dopamine Release Through Optimized Electrical Brain Stimulation funding agency
2021 $1.1MActive
Control of the Time Course of Dopamine Release Through Optimized Electrical Brain Stimulation
Logo of Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease funding agency
2021 $778.9KActive
Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
Logo of Development of Advanced Voltammetric Method for Basal Neurotransmitter Level Measurement funding agency
2019 $236.0KActive
Development of Advanced Voltammetric Method for Basal Neurotransmitter Level Measurement
Logo of Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease funding agency
2019 $385.1K
Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
Logo of Cortical Opioid Dysfunction in Chronic Pain funding agency
2016 $2.7M
Cortical Opioid Dysfunction in Chronic Pain
Logo of PACAP/VIP Glycopeptide Agonists as Neuroprotective Therapies for Parkinson's Disease funding agency
2015 $2.0M
PACAP/VIP Glycopeptide Agonists as Neuroprotective Therapies for Parkinson's Disease
Logo of Direct Measurements of Neurotransmitter Concentrations in Vivo funding agency
2014 $392.6K
Direct Measurements of Neurotransmitter Concentrations in Vivo
Logo of BRAIN EAGER:Integrated Measurement of Dopamine Release and Large-Scale Ensemble Activity in Behaving Animals funding agency
2014 $299.5K
BRAIN EAGER:Integrated Measurement of Dopamine Release and Large-Scale Ensemble Activity in Behaving Animals
Technologies / Patents
Logo of Portable Instrument For Field Ready Electrochemical Experimentation
2022Portable Instrument For Field Ready Electrochemical Experimentation 
Logo of Micelles And Vesicles For The Delivery Of Glycopeptides
2022Micelles And Vesicles For The Delivery Of Glycopeptides 
Logo of Collection and Processing of Analytical Data
2021Collection and Processing of Analytical Data 
Logo of Glycosylated Peptides With Pseudoproline Residues And Having Enhanced Half-Lives And Ability To Cross The Blood Brain Barrier
2020Glycosylated Peptides With Pseudoproline Residues And Having Enhanced Half-Lives And Ability To Cross The Blood Brain Barrier 
Logo of Methods And Systems For Quantification Of Blood-Brain Barrier Permeation Of Glycosylated Peptides
2020Methods And Systems For Quantification Of Blood-Brain Barrier Permeation Of Glycosylated Peptides 
Logo of Glycosylated Peptides with Pseudoproline Residues and Having Enhanced Half-Lives and Ability to Cross the Blood Brain Barrier
1899Glycosylated Peptides with Pseudoproline Residues and Having Enhanced Half-Lives and Ability to Cross the Blood Brain Barrier 
Logo of Portable Instrument For Field Ready Electrochemical Experimentation
1899Portable Instrument For Field Ready Electrochemical Experimentation 
Publications (55)
Recent
2014Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells 
2014Microwave-plasma dry-etch for fabrication of conducting polymer microelectrodes 
2013Oral administration of methylphenidate blocks the effect of cocaine on uptake at the drosophila dopamine transporter 
2013Fast-scan controlled-adsorption voltammetry for the quantification of absolute concentrations and adsorption dynamics 
2013Electrochemical generation of hydroxyl radicals for examining protein structure 
2013Rethinking data collection and signal processing. 2. Preserving the temporal fidelity of electrochemical measurements 
2013The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry 
2012Amperometric noise at thin film band electrodes 
2012Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements 
2012Characterization of poly(3,4-ethylenedioxythiophene):Tosylate conductive polymer microelectrodes for transmitter detection 
2012Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates 
2011Trends in computational simulations of electrochemical processes under hydrodynamic flow in microchannels 
2011Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode Arrays 
2010Nanotome Cluster Bombardment to Recover Spatial Chemistry After Preparation of Biological Samples for SIMS Imaging 
2010Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation 
2010Lipid detection, identification, and imaging single cells with SIMS 
2010Erratum to Multivariate concentration determination using principal component regression with residual analysis [Trends Anal. Chem. 28 (2009) 1127-1136] (DOI:10.1016/j.trac.2009.07.002) 
2010Polymeric crowding agents improve passive biomacromolecule encapsulation in lipid vesicles 
2010Development and characterization of a voltammetric carbon-fiber microelectrode pH sensor 
2010Using in vivo electrochemistry to study the physiological effects of cocaine and other stimulants on the Drosophila melanogaster dopamine transporter 
2010Analytical approaches to investigate transmitter content and release from single secretory vesicles 
2010Probing Exocytosis at Single Cells Using Electrochemistry 
2010Steady-state electrochemical determination of lipidie nanotube diameter utilizing an artificial cell model 
2010Only a fraction of quantal content is released during exocytosis as revealed by electrochemical cytometry of secretory vesicles 
2009Temporal analysis of protozoan lysis in a microfluidic device 
2009In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster 
2009Chemical measurements in Drosophila 
2009Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution 
2009Multivariate concentration determination using principal component regression with residual analysis 
2009Textural guidance cues for controlling process outgrowth of mammalian neurons 
2009Quantitative chemical analysis of single cells. 
2009Hybrid capillary-microfluidic device for the separation, lysis, and electrochemical detection of vesicles 
2008MS/MS methodology to improve subcellular mapping of cholesterol using TOF-SIMS 
2008Amperometric measurements of catecholamine release from single vesicles in MN9D cells 
2008Spatially and temporally resolved single-cell exocytosis utilizing individually addressable carbon microelectrode arrays 
2008Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells 
2007Neurochemical challenge 
2007Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation 
2007Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens 
2007Solution to the neurochemical challenge 
2007Mass spectrometric imaging of the nervous system 
2007Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices 
2007Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior 
2006Phasic dopamine signaling during behavior, reward, and disease states 
2005Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats 
2005Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation 
2004Voltammetric detection of metal nanoparticles separated by liquid chromatography 
2004Resolving neurotransmitters detected by fast-scan cyclic voltammetry 
2004Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats 
2004Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry 
2003Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity 
2003Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo 
2003Erratum: Subsecond dopamine release promotes cocaine seeking (Nature (2003) 422 (614-618)) 
2002Neurochemistry and electroanalytical probes 
2002Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics 
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