KMap

M. Leandro Heien

Associate Professor, Chemistry and Biochemistry-Sci,

Member of the Graduate Faculty,

Chemistry & Biochemistry - Sci
mheien@arizona.edu

520/621-6293

Grant: $10.6M

Courses

Mass Spectrometry

Instrumental Analysis

Analytical Chemistry

Analytical Separations

Advanced Analytical Chemistry

Biochemistry

Advanced Analytical Chemistry Laboratory

Recent Grants

	2021	$2.6M	Active
The Center of Excellence in Addiction Studies (CEAS)
	2021	$1.1M	Active
Control of the Time Course of Dopamine Release Through Optimized Electrical Brain Stimulation
	2021	$778.9K	Active
Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
	2019	$236.0K	Active
Development of Advanced Voltammetric Method for Basal Neurotransmitter Level Measurement
	2019	$385.1K
Mechanisms of Low-Dose Ketamine Treatment for Parkinson's Disease
	2016	$2.7M
Cortical Opioid Dysfunction in Chronic Pain
	2015	$2.0M
PACAP/VIP Glycopeptide Agonists as Neuroprotective Therapies for Parkinson's Disease
	2014	$392.6K
Direct Measurements of Neurotransmitter Concentrations in Vivo
	2014	$299.5K
BRAIN EAGER:Integrated Measurement of Dopamine Release and Large-Scale Ensemble Activity in Behaving Animals

Technologies / Patents

	2022	Portable Instrument For Field Ready Electrochemical Experimentation
	2022	Micelles And Vesicles For The Delivery Of Glycopeptides
	2021	Collection and Processing of Analytical Data
	2020	Glycosylated Peptides With Pseudoproline Residues And Having Enhanced Half-Lives And Ability To Cross The Blood Brain Barrier
	2020	Methods And Systems For Quantification Of Blood-Brain Barrier Permeation Of Glycosylated Peptides
	1899	Glycosylated Peptides with Pseudoproline Residues and Having Enhanced Half-Lives and Ability to Cross the Blood Brain Barrier
	1899	Portable Instrument For Field Ready Electrochemical Experimentation

Publications (55)

Recent

2014	Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells
2014	Microwave-plasma dry-etch for fabrication of conducting polymer microelectrodes
2013	Oral administration of methylphenidate blocks the effect of cocaine on uptake at the drosophila dopamine transporter
2013	Fast-scan controlled-adsorption voltammetry for the quantification of absolute concentrations and adsorption dynamics
2013	Electrochemical generation of hydroxyl radicals for examining protein structure
2013	Rethinking data collection and signal processing. 2. Preserving the temporal fidelity of electrochemical measurements
2013	The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry
2012	Amperometric noise at thin film band electrodes
2012	Rethinking data collection and signal processing. 1. Real-time oversampling filter for chemical measurements
2012	Characterization of poly(3,4-ethylenedioxythiophene):Tosylate conductive polymer microelectrodes for transmitter detection
2012	Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates
2011	Trends in computational simulations of electrochemical processes under hydrodynamic flow in microchannels
2011	Temporal resolution in electrochemical imaging on single PC12 cells using amperometry and voltammetry at microelectrode Arrays
2010	Nanotome Cluster Bombardment to Recover Spatial Chemistry After Preparation of Biological Samples for SIMS Imaging
2010	Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation
2010	Lipid detection, identification, and imaging single cells with SIMS
2010	Erratum to Multivariate concentration determination using principal component regression with residual analysis [Trends Anal. Chem. 28 (2009) 1127-1136] (DOI:10.1016/j.trac.2009.07.002)
2010	Polymeric crowding agents improve passive biomacromolecule encapsulation in lipid vesicles
2010	Development and characterization of a voltammetric carbon-fiber microelectrode pH sensor
2010	Using in vivo electrochemistry to study the physiological effects of cocaine and other stimulants on the Drosophila melanogaster dopamine transporter
2010	Analytical approaches to investigate transmitter content and release from single secretory vesicles
2010	Probing Exocytosis at Single Cells Using Electrochemistry
2010	Steady-state electrochemical determination of lipidie nanotube diameter utilizing an artificial cell model
2010	Only a fraction of quantal content is released during exocytosis as revealed by electrochemical cytometry of secretory vesicles
2009	Temporal analysis of protozoan lysis in a microfluidic device
2009	In vivo electrochemical measurements of exogenously applied dopamine in Drosophila melanogaster
2009	Chemical measurements in Drosophila
2009	Time-of-flight secondary ion mass spectrometry imaging of subcellular lipid heterogeneity: Poisson counting and spatial resolution
2009	Multivariate concentration determination using principal component regression with residual analysis
2009	Textural guidance cues for controlling process outgrowth of mammalian neurons
2009	Quantitative chemical analysis of single cells.
2009	Hybrid capillary-microfluidic device for the separation, lysis, and electrochemical detection of vesicles
2008	MS/MS methodology to improve subcellular mapping of cholesterol using TOF-SIMS
2008	Amperometric measurements of catecholamine release from single vesicles in MN9D cells
2008	Spatially and temporally resolved single-cell exocytosis utilizing individually addressable carbon microelectrode arrays
2008	Freeze-etching and vapor matrix deposition for ToF-SIMS imaging of single cells
2007	Neurochemical challenge
2007	Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation
2007	Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens
2007	Solution to the neurochemical challenge
2007	Mass spectrometric imaging of the nervous system
2007	Mass spectrometric imaging of peptide release from neuronal cells within microfluidic devices
2007	Coordinated Accumbal Dopamine Release and Neural Activity Drive Goal-Directed Behavior
2006	Phasic dopamine signaling during behavior, reward, and disease states
2005	Real-time measurement of dopamine fluctuations after cocaine in the brain of behaving rats
2005	Simultaneous dopamine and single-unit recordings reveal accumbens GABAergic responses: Implications for intracranial self-stimulation
2004	Voltammetric detection of metal nanoparticles separated by liquid chromatography
2004	Resolving neurotransmitters detected by fast-scan cyclic voltammetry
2004	Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
2004	Probing electric fields inside microfluidic channels during electroosmotic flow with fast-scan cyclic voltammetry
2003	Overoxidation of carbon-fiber microelectrodes enhances dopamine adsorption and increases sensitivity
2003	Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo
2003	Erratum: Subsecond dopamine release promotes cocaine seeking (Nature (2003) 422 (614-618))
2002	Neurochemistry and electroanalytical probes
2002	Frequency of dopamine concentration transients increases in dorsal and ventral striatum of male rats during introduction of conspecifics

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