KMap

Michael Brown

Professor, Applied Mathematics - GIDP,

Member of the Graduate Faculty,

Professor, Chemistry and Biochemistry-Sci,

Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
mfbrown@arizona.edu

520/621-2163

Grant: $5.5M

❝

Michael F. Brown is Professor of Chemistry & Biochemistry at the University of Arizona. He is co-director of the Biological Physics Program and the Chemical Physics Program, and was a co-founder of the Biological Chemistry Program at the University of Arizona. He is internationally renowned for his work on the molecular basis of activation of G-protein-coupled receptors that are the targets for the majority of pharmaceuticals and medicines used by humans. The focus of his work is on biomembranes, with a particular emphasis on lipid-protein interactions in relation to potential drug targets involving membrane proteins. He is involved with investigation of the molecular basis of visual signaling involving rhodopsin. Moreover, Professor Brown is an expert in nuclear magnetic resonance (NMR) spectroscopy. His activities in the area of biomolecular NMR spectroscopy involve the devolvement and application of methods for studying the structure and dynamics of biomolecules. Michael Brown has authored over 130 original research papers, 10 book chapters, 4 book reviews, and has published more than 275 abstracts. His current H-index is 43. He numbers among his coworkers various prominent scientists worldwide. He presents his work frequently at national and international conferences, and is the recipient of a number of major awards. Professor Brown's many contributions have established him as a major voice in the area of biomembrane research and biomolecular spectroscopy. He is frequently a member of various review panels and exerts an influence on science policy at the national level. Among his accolades, he is an elected Fellow of the American Association for the Advancement of Science; American Physical Society; Japan Society for the Promotion of Science; and the Biophysical Society. He is a Fellow of the Galileo Circle of the University of Arizona. Most recently, he received the Avanti Award of the Biophysical Society. This premier honor recognizes his vast and innovative contributions to the field of membrane biophysics, and groundbreaking work in the development of NMR techniques to characterize lipid structure and dynamics. Most recently he presented the 2014 Avanti lecture of the Biophysical Society.

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Michael Brown experts in nmr spectroscopy, biophysics, biochemistry, molecular biology, rhodopsin, structural biology, bioengineering, g protein-coupled receptors, biomaterials, tissue engineering, cell biology, ophthalmology, nanophotonics, lipid bilayers, drug delivery, membrane proteins, biomechanics, molecular dynamics, soft matter physics, mri, membranes, spectroscopy, spintronics, lipids, plasmonics, mechanobiology, computational chemistry, molecular simulation, soft matter, rhodops, neutron scattering, condensed matter physics, magnetic resonance imaging, bioinorganic chemistry, microfluidics, dti, rheology, molecular dynamics simulation, lipid membranes, complex fluids, fluid mechanics, gpcrs, biomedical optics, biophotonics, magnetism, biomems, symbiosis, physical chemistry, membrane transport, inorganic chemistry, chemistry, nmr, phospholipids, polymer chemistry, biomedical engineering, neuroscience, pharmacology, x-ray scattering, computational fluid dynamics, biofluids, molecular imaging, nuclear physics, atomic force microscopy, regenerative medicine, turbulence, computational biology, bioinformatics, systems biology, x-ray crystallography, mass spectrometry

Courses

Statistical Thermodynamics

Mathematical Methods for Chemists

Nuclear Magnetic Resonance Spectroscopy

Introduction to Quantum Chemistry

Physical Chemistry

Biophysical Chemistry

Recent Grants

	2019	$400.0K	Active
Essential Role of Water and Lipids in G-Protein-Coupled Receptor Chemistry
	2019	$220.0K	Active
Ultrafast Protein Dynamics Studied by Time-Resolved Solution X-Ray Scattering
	2018	$800.0K	Active
Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering
	2016	$1.1M
Membrane Basis of Visual Excitation
	2015	$262.1K
Regulation of Nonmuscle Myosin Light Chain Kinase Structure and Function of ARDS
	2009	$140.5K
Biophysical and Computational Investigation of the Rhodopsin Activation Mechanism
	2009	$48.8K
Membrane Interactions and Neurodegeneration in Parkinson's Disease
	2008	$1.4M
Membrane Basis of Visual Excitation
	2008	$1.1M
Lipid Modulation of Rhodopsin Signaling in Membranes

Technologies / Patents

	2021	Composition Comprising a Lyophilized Detergent-Solubilized Protein
	2020	Powdered G-Protein Coupled Receptors (GPCR)
	1899	Powdered G-Protein Coupled Receptors (GPCR)

News

2015	Why Black Life Matters: A Reflection
2015	Black Life Matters Conference to Address Violence
2014	How New Social Movements Take Root
2012	Four UA Professors Elected as AAAS Fellows
2010	UA Researcher Wins American Chemical Society Award
2008	Planetary Astronomer Michael Brown to Give Aaronson Memorial Lecture
2001	UA Boasts 5 New Fulbright Scholars, Visiting Scholars

Publications (230)

Recent

2020	span style= font-size:11pt; Rhodopsin Activation in Lipid Membranes Based on Solid-State NMR Spectroscopy /span span style= font-size:medium; /span
2020	span style= font-size:11pt; How Cholesterol Stiffens Unsaturated Lipid Membranes /span span style= font-size:medium; /span
2020	span style= font-size:11pt; Nicotinamide Phosphoribosyltransferase Purification Using SUMO Expression System /span span style= font-size:medium; /span
2019	Effect of Biopolymer Tethers on Antimicrobial Peptide Activity in Biomembranes
2019	Phospholipid Headgroups Govern Emergent Bending Energy of Membranes with Implications for Lipid-Protein Interactions
2019	Structural Fluctuations in Rhodopsin Activation Revealed by Neutron Scattering
2019	Total synthesis of 9-CD3-9-cis-retinal for studying vision
2019	Flexible Surface Model for Lipid-Protein Interactions
2019	Cholesterol effects on the physical properties of lipid membranes viewed by solid-state NMR spectroscopy
2019	Functional Water Dynamics in Rhodopsin Using Solid-State Deuterium NMR Spectroscopy
2019	Flexible Lipid Nanomaterials Studied by NMR Spectroscopy
2019	Deuterium NMR Spectroscopy in Colloid and Surface Chemistry
2019	Soft Interfaces in Membrane Protein-Lipid Interactions
2019	Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsin
2019	Hydration Modulates G-Protein-Coupled Receptor Signaling
2019	G-Protein-Coupled Receptor Activation Mediated by Internal Hydration
2019	Quasielastic and Elastic Neutron Scattering of Membrane Proteins
2019	Retinal Flipping During Rhodopsin Activation Revealed by Solid State 2H NMR and QM/MM Simulations
2019	Rhodopsin Hydration Dynamics Studied by Solid-State Deuterium NMR Spectroscopy
2019	Sponge Model of G-Protein Binding and Unbinding in Membranes
2019	Study of Ultra-Fast Rhodopsin Activation Dynamics with Molecular Dynamics Simulations
2019	Membrane Deformation Under Isotropic External Stress
2019	Mesoscopic Dynamics in Phospholipid Membranes under Osmotic Stress
2018	Soft Matter Influences on G-Protein-Coupled-Receptor Activation Probed by FTIR and UV-Visible Spectroscopy
2018	Hydration Thermodynamics of a Powdered G-Protein-Coupled Receptor
2018	Dynamics of Membrane Proteins Studied by Solid State 2H NMR Relaxation
2018	Emergence of Membrane Material Parameters Revealed by Solid-State 2H NMR Spectroscopy
2018	Small-Angle Neutron Scattering Reveals Energy Landscape For Rhodopsin Photoactivation
2018	G-Protein-Coupled Receptor Activation through Membrane Deformation
2018	Synthesis of 9-CD3-9-cis-Retinal Cofactor of Isorhodopsin
2018	Solid-State 2H NMR Investigations of Viral M2 Ion Channel Drugs
2018	Emergence of Undulations as 2-D Director Fluctuations in Phospholipid Membranes
2018	Investigation of Photoinduced Oligomerization of Rhodopsin By Native Mass Spectrometry
2017	Self-Association and Conformational Stability of NAMPT Protein
2017	Solid-State 2H NMR Studies of Water-Mediated Lipid Membrane Deformation
2017	Membrane Lipid-Protein Interactions
2017	Multiscale GPCR Activation in Lipid Membranes Probed by Solid-State NMR and Scattering Methods
2017	Time-Resolved Wide-Angle X-ray Scattering Reveals Protein Quake in Rhodopsin Activation
2017	Solid-State Deuterium NMR Spectroscopy of Rhodopsin
2017	Activation of GPCR Rhodopsin Investigated by Solid-State NMR Spectroscopy
2017	Collective Dynamics in Lipid Membranes
2017	Concepts and Methods of Deuterium NMR Spectroscopy Applied to Biomembranes
2017	Hydration-Mediated Elastic Deformations in Biological Membranes
2017	Role of Soft Matter in G-Protein-Coupled Receptor Signaling
2017	Energy Landscape and Spatial Motion Models in Rhodopsin Activation
2017	Solid-State Deuterium NMR Spectroscopy of Membranes
2017	Soft Matter in Lipid-Protein Interactions
2016	Computational and Experimental Studies of Lipid-Protein Interactions in Biomemrane Function
2016	Neutron Scattering Reveals Protein Fluctuations in GPCR Activation
2016	Quasi-Elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G-Protein–Coupled Receptor
2016	Hydration Mediated G-Protein-Coupled Receptor Activation,
2016	Retinal Chromophore Structure in Meta-II Rhodopsin Revealed by Solid-State 2H NMR and Molecular Modeling
2016	Cholesterol-Induced Suppression of Membrane Elastic Fluctuations at the Atomistic Level
2016	Elastic Deformation and Collective Dynamics in Lipid Membranes: A Solid-State 2H NMR Relaxation Study
2016	Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. II. Magnetic Resonance Spectroscopy
2016	Thermal Denaturation and Domain Stability of NAMPT Protein
2016	Powdered G-Protein–Coupled Receptors
2015	Investigation of Rhodopsin Dynamics in its Signaling State by Solid-State Deuterium NMR Spectroscopy
2015	Spontaneous Reconstitution of Bovine Rhodopsin into Artificial Membranes
2015	A Usual G-Protein-Coupled Receptor in Unusual Membranes
2015	Membrane-Lipid Mediated Rhodopsin Signaling Involves an Ensemble of Conformational Substates
2015	Retinal Flip in Rhodopsin Activation?
2015	Small Angle Neutron and X-Ray Scattering Reveal Conformational Differences in Detergents Affecting Rhodopsin Activation
2015	Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. I. Vibrational and Electronic Spectroscopy
2015	Hydration-Modulated Collective Dynamics of Membrane Lipids are Revealed by Solid-State 2H NMR Relaxation
2015	Solid-State 2H NMR Investigation of Transducin Activation by Rhodopsin
2015	Elastic Deformation and Area Per Lipid of Membranes: Atomistic View From Solid-State Deuterium NMR Spectroscopy
2015	Rhodopsin Photoactivation Dynamics Revealed by Quasi-Elastic Neutron Scattering
2014	G-Protein-Coupled Receptor Activation Investigated using Small-Angle Neutron Scattering
2014	Experimental and Theoretical Comparison of Pressure Effects on Lipid Bilayer Fluctuations
2014	Intermembrane Forces and Membrane Deformation Observed via Dehydration and Osmotic Pressure
2014	Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures
2014	Role of Membrane Lipids in Activating G-Protein-Coupled Receptors
2014	Retinal Makes Concerted Conformational Changes During Early Stages of Rhodopsin Activation
2014	Generalized Model-Free Analysis of Nuclear Spin Relaxation Experiments
2014	Phospholipid Bilayer Membranes: Deuterium and Carbon-13 NMR Spectroscopy
2014	Ensemble Activation of G-Protein–Coupled Receptors Revealed by Small-Angle Neutron Scattering
2014	Lipid-Mediated Activation of G-Protein-Coupled Receptors in Membranes
2014	Conformational Fluctuations in G-Protein-Coupled Receptors
2014	Investigation of Lipid Bilayer Effects on Rhodopsin Activation using UV-Visible and FTIR Spectroscopy
2014	Generalized Model-Free Spectral Density Analysis Applied to Rhodopsin Activation in Membranes
2014	Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy
2014	Area Per Lipid of Membranes from Natural Abundance Solid-State 13C NMR Spectroscopy
2013	Area per Lipid and Elastic Deformation of Membrane Bilayers Under Osmotic Stress
2013	Solid-State 13C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-synuclein
2013	Activation of rhodopsin based on solid-state NMR spectroscopy
2013	Suppression of Cooperative Motions in Phospholipid Membranes by Osmotic Stress: Deuterium NMR Relaxation Study
2013	Retinal conformation governs pKa of protonated schiff base in rhodopsin activation
2013	Membrane Structure and Intermembrane Forces Observed with Small Angle X-Ray Scattering
2013	Model-Free Spectral Density Mapping Applied to Dynamics of Rhodopsin in Solid-State NMR Spectroscopy
2013	Lipid Bilayer Influences Rhodopsin Activation Probed by FTIR and UV-Visible Spectroscopy
2013	Restructuring of Membrane Bilayers due to Osmotic Pressure: Deuterium Solid-State NMR Study
2013	Solid-state NMR spectroscopy for the physical chemistry laboratory
2013	Retinal Changes Conformation During the Early Stages of Rhodopsin Activation
2013	High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane
2013	Membrane Bilayer Environment Influences Thermodynamics of Rhodopsin Membrane Protein-Lipid Interactions
2013	Secondary Structure and Folding of Amino Acid Transporter from Outer Chloroplast Membrane
2012	Rhodopsin Activation is Modulated by Non-Specific Membrane Lipid-Protein Interactions
2012	Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation
2012	UV-visible and infrared methods for investigating lipid-rhodopsin membrane interactions
2012	Solid-State 2H NMR Reveals Changes in Membrane Flexibility Due to Osmotic Pressure
2012	Membrane Area Deformation under Osmotic Stress: Deuterium NMR Approach
2012	Rhodopsin Simulations in Detergent Micelles Characterize Meta I and Meta II Photointermediates
2012	Hydration-Mediated Slow Dynamics in Phospholipid Membranes
2012	Curvature forces in membrane lipid-protein interactions
2012	Flexible Surface Model for Membrane Lipid-Protein Interactions
2012	Time-Resolved UV-Visible Studies of Rhodopsin Provide Experimental Test of Flexible Surface Model for Lipid-Protein Interactions
2012	NMR Studies on Membrane Protein OEP16
2012	The Retinal Energy Landscape as a Function of the Rhodopsin Photocycle
2012	Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes
2012	Molecular Simulations Illuminate Rhodopsin Activation Based on New Crystal Structures
2012	Intermembrane Forces Probed by Osmotic Stress and Solid-State 2H NMR Spectroscopy
2011	Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation
2011	Retinal Structural Dynamics in Rhodopsin Activation
2011	Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin
2011	An NMR database for simulations of membrane dynamics
2011	Solid-state 2H NMR shows equivalence of dehydration and osmotic pressures in lipid membrane deformation
2011	Steric and electronic influences on the torsional energy landscape of retinal
2010	Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy
2010	The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
2010	Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: The meta IIa conformational substate
2009	Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state 2H NMR spectroscopy
2009	Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory
2008	Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy
2008	Bolalipid membrane structure revealed by solid-state 2H NMR spectroscopy
2008	Ultra-high vacuum surface analysis study of rhodopsin incorporation into supported lipid bilayers
2008	Reconstitution of rhodopsin into polymerizable planar supported lipid bilayers: Influence of dienoyl monomer structure on photoactivation
2008	Two protonation switches control rhodopsin activation in membranes
2008	Fluid mechanical matching of H+-ATP synthase subunit c-ring with lipid membranes revealed by 2H solid-state NMR
2007	Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations
2007	Structural analysis and dynamics of retinal chromophore in dark and meta I states of rhodopsin from 2H NMR of aligned membranes
2007	Solid-State 2H NMR spectroscopy of retinal proteins in aligned membranes
2007	Synthesis of CD3-labeled 11-cis-retinals and application to solid-state deuterium NMR spectroscopy of rhodopsin
2007	X-ray scattering and solid-state deuterium nuclear magnetic resonance probes of structural fluctuations in lipid membranes
2007	Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations
2006	Solid-state 2H NMR structure of retinal in metarhodopsin I
2006	Retinal counterion switch mechanism in vision evaluated by molecular simulations
2006	Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes
2005	Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid-Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy
2005	Rhodopsin Reconstituted into a Planar-Supported Lipid Bilayer Retains Photoactivity after Cross-Linking Polymerization of Lipid Monomers
2005	Lipid modifications of a ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR
2005	Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by 2H NMR and X-ray diffraction
2004	Membrane Model for the G-Protein-Coupled Receptor Rhodopsin: Hydrophobic Interface and Dynamical Structure
2004	Lanosterol and Cholesterol-Induced Variations in Bilayer Elasticity Probed by 2H NMR Relaxation
2004	Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37
2004	Deuterium NMR structure of retinal in the ground state of rhodopsin
2003	NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles
2002	Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by 2H NMR and molecular dynamics simulations
2002	Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids
2002	Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering
2002	Elastic deformation of membrane bilayers probed by deuterium NMR relaxation
2002	Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction
2002	NMR elastometry of fluid membranes in the mesoscopic regime
2001	Composite membrane deformation on the mesoscopic length scale
2001	Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy
2000	Area per lipid and acyl length distributions in fluid phosphatidylcholines determined by 2H NMR spectroscopy
2000	Softening of membrane bilayers by detergents elucidated by deuterium NMR spectroscopy
1999	2H-NMR in liquid crystals and membranes
1999	Structures and synthesis of 4a-homo-7,19-dinorsteroids, X-ray crystallography and NMR spectroscopy
1999	Thermotropic Behavior of Lipophilic Derivatized [60]Fullerenes Studied by Deuterium NMR, X-ray Diffraction, and Microcalorimetry
1999	The angles between the C1-, C5-, and C9-methyl bonds of the retinylidene chromophore and the membrane normal increase in the M intermediate of bacteriorhodopsin: Direct determination with solid-state 2H NMR
1999	Influence of Cholesterol on Dynamics of Dimyristoylphosphatidylcholine Bilayers as Studied by Deuterium NMR Relaxation
1999	Solid-state NMR line shapes of uniaxially oriented immobile systems
1999	Plasmon resonance spectroscopy: Probing molecular interactions within membranes
1998	Lipid Bilayer Dynamics from Simultaneous Analysis of Orientation and Frequency Dependence of Deuterium Spin-Lattice and Quadrupolar Order Relaxation
1998	Chromophore orientation in bacteriorhodopsin determined from the angular dependence of deuterium nuclear magnetic resonance spectra of oriented purple membranes
1998	Structure of the A-form and B-form of DNA from deuterium NMR line shape simulation
1997	Dynamics of lipid bilayers from comparative analysis of 2H and 13C nuclear magnetic resonance relaxation data as a function of frequency and temperature
1997	Influence of Nonlamellar-Forming Lipids on Rhodopsin
1997	Correlation Functions for Lipid Membrane Fluctuations Obtained from NMR Spectroscopy
1997	1H-{125Te} Indirect Detection in Nuclear Magnetic Resonance Spectra of Organotellurium Compounds
1996	Surface plasmon resonance spectroscopy studies of membrane proteins: Transducin binding and activation by rhodopsin monitored in thin membrane films
1996	Fast field-cycling nuclear magnetic resonance spectrometer
1995	Indirect Detection of Selenium-77 in Nuclear Magnetic Resonance Spectra of Organoselenium Compounds
1995	Molecular Dynamics of Vesicles of Unsaturated Phosphatidylcholines Studied by 13C NMR Spin-Lattice Relaxation
1994	Modulation of rhodopsin function by properties of the membrane bilayer
1994	Angular Dependence of Deuterium Spin-Lattice Relaxation of Dilaurylphosphatidylcholine in the Liquid-Crystalline Phase
1994	Conformational Changes in Rhodopsin Probed by Surface Plasmon Resonance Spectroscopy
1994	Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: A wide-line deuterium and phosphorus-31 NMR study
1994	A personal computer-based nuclear magnetic resonance spectrometer
1993	Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes
1993	Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy
1992	Detection of atherosclerosis via magnetic resonance imaging
1992	Photoinduced destabilization of liposomes
1992	31P NMR and X-ray diffraction study of the effect of photopolymerization on lipid polymorphism
1992	Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine
1991	Role of phosphatidylserine in the MI-MIII equilibrium of rhodopsin
1991	Bilayers of Arachidonic Acid Containing Phospholipids Studied By 2H and 31P NMR Spectroscopy
1991	Membrane lipid influences on the energetics of the metarhodopsin I and metarhodopsin II conformational states of rhodopsin probed by flash photolysis.
1991	Effect of bile salts on monolayer curvature of a phosphatidylethanolamine/water model membrane system
1991	Magnetic resonance imaging of lipid deposits in human atheroma via a stimulated-echo diffusion-weighted technique
1991	Low Temperature 2H NMR Spectroscopy of Phospholipid Bilayers Containing Docosahexaenoyl (22:6ω3) Chains
1991	Molecular areas of phospholipids as determined by 2H NMR spectroscopy. Comparison of phosphatidylethanolamines and phosphatidylcholines
1990	Frequency Dependent 2H N.M.R. Relaxation Rates of Small Unilamellar Vesicles
1990	Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy
1990	Orientational anisotropy of nuclear spin relaxation in phospholipid membranes
1990	Magnetic Alignment and Orientational Order of Dipalmitoylphosphatidylcholine Bilayers Containing Palmitoyllyso-phosphatidylcholine
1990	Influence of pH on the MI-MII equilibrium of rhodopsin in recombinant membranes
1988	Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging
1988	High-resolution 1H NMR spectral signature from human atheroma
1988	Lipid-protein interactions mediate the photochemical function of rhodopsin
1987	High-resolution proton NMR spectra of human arterial plaque
1987	Configurational statistics of acyl chains in polyunsaturated lipid bilayers from 2H NMR
1986	Erratum: 31P NMR spectra of rod outer segment and sarcoplasmic reticulum membranes show no evidence of immobilized components due to lipid-protein interactions (Biochemistry (1986) 25:13 (3742-3748))
1986	31P NMR spectra of Rod Outer Segment and Sarcoplasmic Reticulum membranes show no evidence of immobilized components due to lipid-protein interactions
1985	Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids
1985	Frequency dependence of spin-lattice relaxation times of lipid bilayers
1985	Membrane NMR: a dynamic research area
1985	Dependence of deuterium spin-lattice relaxation rates of multilamellar phospholipid dispersions on orientational order
1984	The quadrupolar spectrum of a spin I = 1 in a lipid bilayer in the presence of paramagnetic ions
1984	14N NMR of lipid bilayers: Effects of ions and anesthetics
1983	Theory of spin-lattice relaxation in lipid bilayers and biological membranes. Dipolar relaxation
1983	Unified picture for spin-lattice relaxation of lipid bilayers and biomembranes
1983	New view of lipid bilayer dynamics from 2H and 13C NMR relaxation time measurements
1983	Lipid bilayer dynamics and rhodopsin-lipid interactions: New approach using high-resolution solid-state 13C NMR
1982	Proton, carbon-13, and phosphorus-31 NMR methods for the investigation of rhodopsin-lipid interactions in retinal rod outer segment membranes
1982	Theory of spin-lattice relaxation in lipid bilayers and biological membranes. 2H and 14N quadrupolar relaxation
1981	Orientation and frequency dependence of the deuterium spin-lattice relaxation in multilamellar phospholipid dispersions: implications for dynamic models of membrane structure
1981	Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a 31P NMR study
1979	Deuterium relaxation and molecular dynamics in lipid bilayers
1979	Histidyl and tyrosyl residue ionization studies of subtilisin novo
1979	Structural dynamics in phospholipid bilayers from deuterium spin-lattice relaxation time measurements
1978	Influence of cholesterol on the polar region of phosphatidylcholine and phosphatidylethanolamine bilayers
1977	Ion-induced changes in head group conformation of lecithin bilayers
1977	Quenching of the tyrosyl and tryptophyl fluorescence of subtilisins Carlsberg and Novo by iodide
1977	Proton spin lattice relaxation of retinal rod outer segment membranes and liposomes of extracted phospholipids
1977	Resolution of independently titrating spectral components of the ultraviolet circular dichroism of subtilisin enzymes by matrix rank analysis
1977	Interpretation of 100- and 360-MHz proton magnetic resonance spectra of retinal rod outer segment disk membranes
1976	1H-NMR studies of protein-lipid interactions in retinal rod outer segment disc membranes
1975	Circular dichroism and gel filtration behavior of subtilisin enzymes in concentrated solutions of guanidine hydrochloride

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