Photo of Michael Brown(mfbrown)

Michael Brown

Professor, Applied Mathematics - GIDP,
Member of the Graduate Faculty,
Professor, Chemistry and Biochemistry-Sci,
Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
UAVitae logogoogle scholar logo
Grant: $5.5M
Michael F. Brown is Professor of Chemistry & Biochemistry at the University of Arizona. He is co-director of the Biological Physics Program and the Chemical Physics Program, and was a co-founder of the Biological Chemistry Program at the University of Arizona. He is internationally renowned for his work on the molecular basis of activation of G-protein-coupled receptors that are the targets for the majority of pharmaceuticals and medicines used by humans. The focus of his work is on biomembranes, with a particular emphasis on lipid-protein interactions in relation to potential drug targets involving membrane proteins. He is involved with investigation of the molecular basis of visual signaling involving rhodopsin. Moreover, Professor Brown is an expert in nuclear magnetic resonance (NMR) spectroscopy. His activities in the area of biomolecular NMR spectroscopy involve the devolvement and application of methods for studying the structure and dynamics of biomolecules. Michael Brown has authored over 130 original research papers, 10 book chapters, 4 book reviews, and has published more than 275 abstracts. His current H-index is 43. He numbers among his coworkers various prominent scientists worldwide. He presents his work frequently at national and international conferences, and is the recipient of a number of major awards. Professor Brown's many contributions have established him as a major voice in the area of biomembrane research and biomolecular spectroscopy. He is frequently a member of various review panels and exerts an influence on science policy at the national level. Among his accolades, he is an elected Fellow of the American Association for the Advancement of Science; American Physical Society; Japan Society for the Promotion of Science; and the Biophysical Society. He is a Fellow of the Galileo Circle of the University of Arizona. Most recently, he received the Avanti Award of the Biophysical Society. This premier honor recognizes his vast and innovative contributions to the field of membrane biophysics, and groundbreaking work in the development of NMR techniques to characterize lipid structure and dynamics. Most recently he presented the 2014 Avanti lecture of the Biophysical Society.
Michael Brown experts in nmr spectroscopy, biophysics, biochemistry, molecular biology, rhodopsin, structural biology, bioengineering, g protein-coupled receptors, biomaterials, tissue engineering, cell biology, ophthalmology, nanophotonics, lipid bilayers, drug delivery, membrane proteins, biomechanics, molecular dynamics, soft matter physics, mri, membranes, spectroscopy, spintronics, lipids, plasmonics, mechanobiology, computational chemistry, molecular simulation, soft matter, rhodops, neutron scattering, condensed matter physics, magnetic resonance imaging, bioinorganic chemistry, microfluidics, dti, rheology, molecular dynamics simulation, lipid membranes, complex fluids, fluid mechanics, gpcrs, biomedical optics, biophotonics, magnetism, biomems, symbiosis, physical chemistry, membrane transport, inorganic chemistry, chemistry, nmr, phospholipids, polymer chemistry, biomedical engineering, neuroscience, pharmacology, x-ray scattering, computational fluid dynamics, biofluids, molecular imaging, nuclear physics, atomic force microscopy, regenerative medicine, turbulence, computational biology, bioinformatics, systems biology, x-ray crystallography, mass spectrometry
Statistical Thermodynamics 
Mathematical Methods for Chemists 
Nuclear Magnetic Resonance Spectroscopy 
Introduction to Quantum Chemistry 
Physical Chemistry 
Biophysical Chemistry 
Recent Grants
Logo of Essential Role of Water and Lipids in G-Protein-Coupled Receptor Chemistry funding agency
2019 $400.0KActive
Essential Role of Water and Lipids in G-Protein-Coupled Receptor Chemistry
Logo of Ultrafast Protein Dynamics Studied by Time-Resolved Solution X-Ray Scattering funding agency
2019 $220.0KActive
Ultrafast Protein Dynamics Studied by Time-Resolved Solution X-Ray Scattering
Logo of Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering funding agency
2018 $800.0KActive
Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering
Logo of Membrane Basis of Visual Excitation funding agency
2016 $1.1M
Membrane Basis of Visual Excitation
Logo of Regulation of Nonmuscle Myosin Light Chain Kinase Structure and Function of ARDS funding agency
2015 $262.1K
Regulation of Nonmuscle Myosin Light Chain Kinase Structure and Function of ARDS
Logo of Biophysical and Computational Investigation of the Rhodopsin Activation Mechanism funding agency
2009 $140.5K
Biophysical and Computational Investigation of the Rhodopsin Activation Mechanism
Logo of Membrane Interactions and Neurodegeneration in Parkinson's Disease funding agency
2009 $48.8K
Membrane Interactions and Neurodegeneration in Parkinson's Disease
Logo of Membrane Basis of Visual Excitation funding agency
2008 $1.4M
Membrane Basis of Visual Excitation
Logo of Lipid Modulation of Rhodopsin Signaling in Membranes funding agency
2008 $1.1M
Lipid Modulation of Rhodopsin Signaling in Membranes
Technologies / Patents
Logo of Composition Comprising a Lyophilized Detergent-Solubilized Protein
2021Composition Comprising a Lyophilized Detergent-Solubilized Protein 
Logo of Powdered G-Protein Coupled Receptors (GPCR)
2020Powdered G-Protein Coupled Receptors (GPCR) 
Logo of Powdered G-Protein Coupled Receptors (GPCR)
1899Powdered G-Protein Coupled Receptors (GPCR) 
2015Why Black Life Matters: A Reflection 
2015Black Life Matters Conference to Address Violence 
2014How New Social Movements Take Root 
2012Four UA Professors Elected as AAAS Fellows 
2010UA Researcher Wins American Chemical Society Award 
2008Planetary Astronomer Michael Brown to Give Aaronson Memorial Lecture  
2001UA Boasts 5 New Fulbright Scholars, Visiting Scholars 
Publications (230)
2020span style= font-size:11pt; Rhodopsin Activation in Lipid Membranes Based on Solid-State NMR Spectroscopy /span span style= font-size:medium; /span 
2020span style= font-size:11pt; How Cholesterol Stiffens Unsaturated Lipid Membranes /span span style= font-size:medium; /span 
2020span style= font-size:11pt; Nicotinamide Phosphoribosyltransferase Purification Using SUMO Expression System /span span style= font-size:medium; /span 
2019Effect of Biopolymer Tethers on Antimicrobial Peptide Activity in Biomembranes 
2019Phospholipid Headgroups Govern Emergent Bending Energy of Membranes with Implications for Lipid-Protein Interactions 
2019Structural Fluctuations in Rhodopsin Activation Revealed by Neutron Scattering 
2019Total synthesis of 9-CD3-9-cis-retinal for studying vision 
2019Flexible Surface Model for Lipid-Protein Interactions 
2019Cholesterol effects on the physical properties of lipid membranes viewed by solid-state NMR spectroscopy 
2019Functional Water Dynamics in Rhodopsin Using Solid-State Deuterium NMR Spectroscopy 
2019Flexible Lipid Nanomaterials Studied by NMR Spectroscopy 
2019Deuterium NMR Spectroscopy in Colloid and Surface Chemistry 
2019Soft Interfaces in Membrane Protein-Lipid Interactions 
2019Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsin 
2019Hydration Modulates G-Protein-Coupled Receptor Signaling 
2019G-Protein-Coupled Receptor Activation Mediated by Internal Hydration 
2019Quasielastic and Elastic Neutron Scattering of Membrane Proteins 
2019Retinal Flipping During Rhodopsin Activation Revealed by Solid State 2H NMR and QM/MM Simulations 
2019Rhodopsin Hydration Dynamics Studied by Solid-State Deuterium NMR Spectroscopy 
2019Sponge Model of G-Protein Binding and Unbinding in Membranes 
2019Study of Ultra-Fast Rhodopsin Activation Dynamics with Molecular Dynamics Simulations 
2019Membrane Deformation Under Isotropic External Stress 
2019Mesoscopic Dynamics in Phospholipid Membranes under Osmotic Stress 
2018Soft Matter Influences on G-Protein-Coupled-Receptor Activation Probed by FTIR and UV-Visible Spectroscopy 
2018Hydration Thermodynamics of a Powdered G-Protein-Coupled Receptor 
2018Dynamics of Membrane Proteins Studied by Solid State 2H NMR Relaxation 
2018Emergence of Membrane Material Parameters Revealed by Solid-State 2H NMR Spectroscopy 
2018Small-Angle Neutron Scattering Reveals Energy Landscape For Rhodopsin Photoactivation 
2018G-Protein-Coupled Receptor Activation through Membrane Deformation 
2018Synthesis of 9-CD3-9-cis-Retinal Cofactor of Isorhodopsin 
2018Solid-State 2H NMR Investigations of Viral M2 Ion Channel Drugs 
2018Emergence of Undulations as 2-D Director Fluctuations in Phospholipid Membranes 
2018Investigation of Photoinduced Oligomerization of Rhodopsin By Native Mass Spectrometry 
2017Self-Association and Conformational Stability of NAMPT Protein 
2017Solid-State 2H NMR Studies of Water-Mediated Lipid Membrane Deformation 
2017Membrane Lipid-Protein Interactions 
2017Multiscale GPCR Activation in Lipid Membranes Probed by Solid-State NMR and Scattering Methods 
2017Time-Resolved Wide-Angle X-ray Scattering Reveals Protein Quake in Rhodopsin Activation 
2017Solid-State Deuterium NMR Spectroscopy of Rhodopsin 
2017Activation of GPCR Rhodopsin Investigated by Solid-State NMR Spectroscopy 
2017Collective Dynamics in Lipid Membranes 
2017Concepts and Methods of Deuterium NMR Spectroscopy Applied to Biomembranes 
2017Hydration-Mediated Elastic Deformations in Biological Membranes 
2017Role of Soft Matter in G-Protein-Coupled Receptor Signaling 
2017Energy Landscape and Spatial Motion Models in Rhodopsin Activation 
2017Solid-State Deuterium NMR Spectroscopy of Membranes 
2017Soft Matter in Lipid-Protein Interactions 
2016Computational and Experimental Studies of Lipid-Protein Interactions in Biomemrane Function 
2016Neutron Scattering Reveals Protein Fluctuations in GPCR Activation 
2016Quasi-Elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G-Protein–Coupled Receptor 
2016Hydration Mediated G-Protein-Coupled Receptor Activation, 
2016Retinal Chromophore Structure in Meta-II Rhodopsin Revealed by Solid-State 2H NMR and Molecular Modeling 
2016Cholesterol-Induced Suppression of Membrane Elastic Fluctuations at the Atomistic Level 
2016Elastic Deformation and Collective Dynamics in Lipid Membranes: A Solid-State 2H NMR Relaxation Study 
2016Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. II. Magnetic Resonance Spectroscopy 
2016Thermal Denaturation and Domain Stability of NAMPT Protein 
2016Powdered G-Protein–Coupled Receptors 
2015Investigation of Rhodopsin Dynamics in its Signaling State by Solid-State Deuterium NMR Spectroscopy 
2015Spontaneous Reconstitution of Bovine Rhodopsin into Artificial Membranes 
2015A Usual G-Protein-Coupled Receptor in Unusual Membranes 
2015Membrane-Lipid Mediated Rhodopsin Signaling Involves an Ensemble of Conformational Substates 
2015Retinal Flip in Rhodopsin Activation? 
2015Small Angle Neutron and X-Ray Scattering Reveal Conformational Differences in Detergents Affecting Rhodopsin Activation 
2015Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. I. Vibrational and Electronic Spectroscopy 
2015Hydration-Modulated Collective Dynamics of Membrane Lipids are Revealed by Solid-State 2H NMR Relaxation 
2015Solid-State 2H NMR Investigation of Transducin Activation by Rhodopsin 
2015Elastic Deformation and Area Per Lipid of Membranes: Atomistic View From Solid-State Deuterium NMR Spectroscopy 
2015Rhodopsin Photoactivation Dynamics Revealed by Quasi-Elastic Neutron Scattering 
2014G-Protein-Coupled Receptor Activation Investigated using Small-Angle Neutron Scattering 
2014Experimental and Theoretical Comparison of Pressure Effects on Lipid Bilayer Fluctuations 
2014Intermembrane Forces and Membrane Deformation Observed via Dehydration and Osmotic Pressure 
2014Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures 
2014Role of Membrane Lipids in Activating G-Protein-Coupled Receptors 
2014Retinal Makes Concerted Conformational Changes During Early Stages of Rhodopsin Activation 
2014Generalized Model-Free Analysis of Nuclear Spin Relaxation Experiments 
2014Phospholipid Bilayer Membranes: Deuterium and Carbon-13 NMR Spectroscopy 
2014Ensemble Activation of G-Protein–Coupled Receptors Revealed by Small-Angle Neutron Scattering 
2014Lipid-Mediated Activation of G-Protein-Coupled Receptors in Membranes 
2014Conformational Fluctuations in G-Protein-Coupled Receptors 
2014Investigation of Lipid Bilayer Effects on Rhodopsin Activation using UV-Visible and FTIR Spectroscopy 
2014Generalized Model-Free Spectral Density Analysis Applied to Rhodopsin Activation in Membranes 
2014Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy 
2014Area Per Lipid of Membranes from Natural Abundance Solid-State 13C NMR Spectroscopy 
2013Area per Lipid and Elastic Deformation of Membrane Bilayers Under Osmotic Stress 
2013Solid-State 13C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-synuclein 
2013Activation of rhodopsin based on solid-state NMR spectroscopy 
2013Suppression of Cooperative Motions in Phospholipid Membranes by Osmotic Stress: Deuterium NMR Relaxation Study 
2013Retinal conformation governs pKa of protonated schiff base in rhodopsin activation 
2013Membrane Structure and Intermembrane Forces Observed with Small Angle X-Ray Scattering 
2013Model-Free Spectral Density Mapping Applied to Dynamics of Rhodopsin in Solid-State NMR Spectroscopy 
2013Lipid Bilayer Influences Rhodopsin Activation Probed by FTIR and UV-Visible Spectroscopy 
2013Restructuring of Membrane Bilayers due to Osmotic Pressure: Deuterium Solid-State NMR Study 
2013Solid-state NMR spectroscopy for the physical chemistry laboratory 
2013Retinal Changes Conformation During the Early Stages of Rhodopsin Activation 
2013High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane 
2013Membrane Bilayer Environment Influences Thermodynamics of Rhodopsin Membrane Protein-Lipid Interactions 
2013Secondary Structure and Folding of Amino Acid Transporter from Outer Chloroplast Membrane 
2012Rhodopsin Activation is Modulated by Non-Specific Membrane Lipid-Protein Interactions 
2012Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation 
2012UV-visible and infrared methods for investigating lipid-rhodopsin membrane interactions 
2012Solid-State 2H NMR Reveals Changes in Membrane Flexibility Due to Osmotic Pressure 
2012Membrane Area Deformation under Osmotic Stress: Deuterium NMR Approach 
2012Rhodopsin Simulations in Detergent Micelles Characterize Meta I and Meta II Photointermediates 
2012Hydration-Mediated Slow Dynamics in Phospholipid Membranes 
2012Curvature forces in membrane lipid-protein interactions 
2012Flexible Surface Model for Membrane Lipid-Protein Interactions 
2012Time-Resolved UV-Visible Studies of Rhodopsin Provide Experimental Test of Flexible Surface Model for Lipid-Protein Interactions 
2012NMR Studies on Membrane Protein OEP16 
2012The Retinal Energy Landscape as a Function of the Rhodopsin Photocycle 
2012Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes 
2012Molecular Simulations Illuminate Rhodopsin Activation Based on New Crystal Structures 
2012Intermembrane Forces Probed by Osmotic Stress and Solid-State 2H NMR Spectroscopy 
2011Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation 
2011Retinal Structural Dynamics in Rhodopsin Activation 
2011Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin 
2011An NMR database for simulations of membrane dynamics 
2011Solid-state 2H NMR shows equivalence of dehydration and osmotic pressures in lipid membrane deformation 
2011Steric and electronic influences on the torsional energy landscape of retinal 
2010Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy 
2010The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding 
2010Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: The meta IIa conformational substate 
2009Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state 2H NMR spectroscopy 
2009Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory 
2008Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy 
2008Bolalipid membrane structure revealed by solid-state 2H NMR spectroscopy 
2008Ultra-high vacuum surface analysis study of rhodopsin incorporation into supported lipid bilayers 
2008Reconstitution of rhodopsin into polymerizable planar supported lipid bilayers: Influence of dienoyl monomer structure on photoactivation 
2008Two protonation switches control rhodopsin activation in membranes 
2008Fluid mechanical matching of H+-ATP synthase subunit c-ring with lipid membranes revealed by 2H solid-state NMR 
2007Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations 
2007Structural analysis and dynamics of retinal chromophore in dark and meta I states of rhodopsin from 2H NMR of aligned membranes 
2007Solid-State 2H NMR spectroscopy of retinal proteins in aligned membranes 
2007Synthesis of CD3-labeled 11-cis-retinals and application to solid-state deuterium NMR spectroscopy of rhodopsin 
2007X-ray scattering and solid-state deuterium nuclear magnetic resonance probes of structural fluctuations in lipid membranes 
2007Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations 
2006Solid-state 2H NMR structure of retinal in metarhodopsin I 
2006Retinal counterion switch mechanism in vision evaluated by molecular simulations 
2006Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes 
2005Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid-Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy 
2005Rhodopsin Reconstituted into a Planar-Supported Lipid Bilayer Retains Photoactivity after Cross-Linking Polymerization of Lipid Monomers 
2005Lipid modifications of a ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR 
2005Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by 2H NMR and X-ray diffraction 
2004Membrane Model for the G-Protein-Coupled Receptor Rhodopsin: Hydrophobic Interface and Dynamical Structure 
2004Lanosterol and Cholesterol-Induced Variations in Bilayer Elasticity Probed by 2H NMR Relaxation 
2004Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37 
2004Deuterium NMR structure of retinal in the ground state of rhodopsin 
2003NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles 
2002Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by 2H NMR and molecular dynamics simulations 
2002Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids 
2002Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering 
2002Elastic deformation of membrane bilayers probed by deuterium NMR relaxation 
2002Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction 
2002NMR elastometry of fluid membranes in the mesoscopic regime 
2001Composite membrane deformation on the mesoscopic length scale 
2001Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy 
2000Area per lipid and acyl length distributions in fluid phosphatidylcholines determined by 2H NMR spectroscopy 
2000Softening of membrane bilayers by detergents elucidated by deuterium NMR spectroscopy 
19992H-NMR in liquid crystals and membranes 
1999Structures and synthesis of 4a-homo-7,19-dinorsteroids, X-ray crystallography and NMR spectroscopy 
1999Thermotropic Behavior of Lipophilic Derivatized [60]Fullerenes Studied by Deuterium NMR, X-ray Diffraction, and Microcalorimetry 
1999The angles between the C1-, C5-, and C9-methyl bonds of the retinylidene chromophore and the membrane normal increase in the M intermediate of bacteriorhodopsin: Direct determination with solid-state 2H NMR 
1999Influence of Cholesterol on Dynamics of Dimyristoylphosphatidylcholine Bilayers as Studied by Deuterium NMR Relaxation 
1999Solid-state NMR line shapes of uniaxially oriented immobile systems 
1999Plasmon resonance spectroscopy: Probing molecular interactions within membranes 
1998Lipid Bilayer Dynamics from Simultaneous Analysis of Orientation and Frequency Dependence of Deuterium Spin-Lattice and Quadrupolar Order Relaxation 
1998Chromophore orientation in bacteriorhodopsin determined from the angular dependence of deuterium nuclear magnetic resonance spectra of oriented purple membranes 
1998Structure of the A-form and B-form of DNA from deuterium NMR line shape simulation 
1997Dynamics of lipid bilayers from comparative analysis of 2H and 13C nuclear magnetic resonance relaxation data as a function of frequency and temperature 
1997Influence of Nonlamellar-Forming Lipids on Rhodopsin 
1997Correlation Functions for Lipid Membrane Fluctuations Obtained from NMR Spectroscopy 
19971H-{125Te} Indirect Detection in Nuclear Magnetic Resonance Spectra of Organotellurium Compounds 
1996Surface plasmon resonance spectroscopy studies of membrane proteins: Transducin binding and activation by rhodopsin monitored in thin membrane films 
1996Fast field-cycling nuclear magnetic resonance spectrometer 
1995Indirect Detection of Selenium-77 in Nuclear Magnetic Resonance Spectra of Organoselenium Compounds 
1995Molecular Dynamics of Vesicles of Unsaturated Phosphatidylcholines Studied by 13C NMR Spin-Lattice Relaxation 
1994Modulation of rhodopsin function by properties of the membrane bilayer 
1994Angular Dependence of Deuterium Spin-Lattice Relaxation of Dilaurylphosphatidylcholine in the Liquid-Crystalline Phase 
1994Conformational Changes in Rhodopsin Probed by Surface Plasmon Resonance Spectroscopy 
1994Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: A wide-line deuterium and phosphorus-31 NMR study 
1994A personal computer-based nuclear magnetic resonance spectrometer 
1993Lipid headgroup and acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes 
1993Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy 
1992Detection of atherosclerosis via magnetic resonance imaging 
1992Photoinduced destabilization of liposomes 
199231P NMR and X-ray diffraction study of the effect of photopolymerization on lipid polymorphism 
1992Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine 
1991Role of phosphatidylserine in the MI-MIII equilibrium of rhodopsin 
1991Bilayers of Arachidonic Acid Containing Phospholipids Studied By 2H and 31P NMR Spectroscopy 
1991Membrane lipid influences on the energetics of the metarhodopsin I and metarhodopsin II conformational states of rhodopsin probed by flash photolysis. 
1991Effect of bile salts on monolayer curvature of a phosphatidylethanolamine/water model membrane system 
1991Magnetic resonance imaging of lipid deposits in human atheroma via a stimulated-echo diffusion-weighted technique 
1991Low Temperature 2H NMR Spectroscopy of Phospholipid Bilayers Containing Docosahexaenoyl (22:6ω3) Chains 
1991Molecular areas of phospholipids as determined by 2H NMR spectroscopy. Comparison of phosphatidylethanolamines and phosphatidylcholines 
1990Frequency Dependent 2H N.M.R. Relaxation Rates of Small Unilamellar Vesicles 
1990Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy 
1990Orientational anisotropy of nuclear spin relaxation in phospholipid membranes 
1990Magnetic Alignment and Orientational Order of Dipalmitoylphosphatidylcholine Bilayers Containing Palmitoyllyso-phosphatidylcholine 
1990Influence of pH on the MI-MII equilibrium of rhodopsin in recombinant membranes 
1988Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging 
1988High-resolution 1H NMR spectral signature from human atheroma 
1988Lipid-protein interactions mediate the photochemical function of rhodopsin 
1987High-resolution proton NMR spectra of human arterial plaque 
1987Configurational statistics of acyl chains in polyunsaturated lipid bilayers from 2H NMR 
1986Erratum: 31P NMR spectra of rod outer segment and sarcoplasmic reticulum membranes show no evidence of immobilized components due to lipid-protein interactions (Biochemistry (1986) 25:13 (3742-3748)) 
198631P NMR spectra of Rod Outer Segment and Sarcoplasmic Reticulum membranes show no evidence of immobilized components due to lipid-protein interactions 
1985Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids 
1985Frequency dependence of spin-lattice relaxation times of lipid bilayers 
1985Membrane NMR: a dynamic research area 
1985Dependence of deuterium spin-lattice relaxation rates of multilamellar phospholipid dispersions on orientational order 
1984The quadrupolar spectrum of a spin I = 1 in a lipid bilayer in the presence of paramagnetic ions 
198414N NMR of lipid bilayers: Effects of ions and anesthetics 
1983Theory of spin-lattice relaxation in lipid bilayers and biological membranes. Dipolar relaxation 
1983Unified picture for spin-lattice relaxation of lipid bilayers and biomembranes 
1983New view of lipid bilayer dynamics from 2H and 13C NMR relaxation time measurements 
1983Lipid bilayer dynamics and rhodopsin-lipid interactions: New approach using high-resolution solid-state 13C NMR 
1982Proton, carbon-13, and phosphorus-31 NMR methods for the investigation of rhodopsin-lipid interactions in retinal rod outer segment membranes 
1982Theory of spin-lattice relaxation in lipid bilayers and biological membranes. 2H and 14N quadrupolar relaxation 
1981Orientation and frequency dependence of the deuterium spin-lattice relaxation in multilamellar phospholipid dispersions: implications for dynamic models of membrane structure 
1981Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a 31P NMR study 
1979Deuterium relaxation and molecular dynamics in lipid bilayers 
1979Histidyl and tyrosyl residue ionization studies of subtilisin novo 
1979Structural dynamics in phospholipid bilayers from deuterium spin-lattice relaxation time measurements 
1978Influence of cholesterol on the polar region of phosphatidylcholine and phosphatidylethanolamine bilayers 
1977Ion-induced changes in head group conformation of lecithin bilayers 
1977Quenching of the tyrosyl and tryptophyl fluorescence of subtilisins Carlsberg and Novo by iodide 
1977Proton spin lattice relaxation of retinal rod outer segment membranes and liposomes of extracted phospholipids 
1977Resolution of independently titrating spectral components of the ultraviolet circular dichroism of subtilisin enzymes by matrix rank analysis 
1977Interpretation of 100- and 360-MHz proton magnetic resonance spectra of retinal rod outer segment disk membranes 
19761H-NMR studies of protein-lipid interactions in retinal rod outer segment disc membranes 
1975Circular dichroism and gel filtration behavior of subtilisin enzymes in concentrated solutions of guanidine hydrochloride