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Michael F. Brown is Professor of Chemistry & Biochemistry at the University of Arizona. He is co-director of the Biological Physics Program and the Chemical Physics Program, and was a co-founder of the Biological Chemistry Program at the University of Arizona. He is internationally renowned for his work on the molecular basis of activation of G-protein-coupled receptors that are the targets for the majority of pharmaceuticals and medicines used by humans. The focus of his work is on biomembranes, with a particular emphasis on lipid-protein interactions in relation to potential drug targets involving membrane proteins. He is involved with investigation of the molecular basis of visual signaling involving rhodopsin. Moreover, Professor Brown is an expert in nuclear magnetic resonance (NMR) spectroscopy. His activities in the area of biomolecular NMR spectroscopy involve the devolvement and application of methods for studying the structure and dynamics of biomolecules. Michael Brown has authored over 130 original research papers, 10 book chapters, 4 book reviews, and has published more than 275 abstracts. His current H-index is 43. He numbers among his coworkers various prominent scientists worldwide. He presents his work frequently at national and international conferences, and is the recipient of a number of major awards. Professor Brown's many contributions have established him as a major voice in the area of biomembrane research and biomolecular spectroscopy. He is frequently a member of various review panels and exerts an influence on science policy at the national level. Among his accolades, he is an elected Fellow of the American Association for the Advancement of Science; American Physical Society; Japan Society for the Promotion of Science; and the Biophysical Society. He is a Fellow of the Galileo Circle of the University of Arizona. Most recently, he received the Avanti Award of the Biophysical Society. This premier honor recognizes his vast and innovative contributions to the field of membrane biophysics, and groundbreaking work in the development of NMR techniques to characterize lipid structure and dynamics. Most recently he presented the 2014 Avanti lecture of the Biophysical Society.Show Less
Courses
- STStatistical Thermodynamics
- NMRNuclear Magnetic Resonance Spectroscopy
- BCBiophysical Chemistry
- MMCMathematical Methods for Chemists
- IQCIntroduction to Quantum Chemistry
- PCPhysical Chemistry
Student Thesis/Dissertation
- HYDRATION AND LIPID INFLUENCES ON G-PROTEIN-COUPLED RECEPTOR ACTIVATION
2021
bachelors - New Insights into the Mechanisms of Antiviral Resistance and Action
2020
doctoral - Studying Molecular Motions of Antiviral Drugs Using Deuterium NMR
2019
doctoral - Theory and Applications of Solid-State NMR Spectroscopy to Biomembrane Structure and Dynamics
2018
doctoral - Investigation of Rhodopsin Activation Using Spectroscopic and Scattering Techniques
2017
doctoral - Role of Membrane Lipids and Hydration in G-Protein–Coupled Receptor Signaling
2017
doctoral - Study of the Structure of Rhodopsin during Photoactivation
2015
bachelors
Grants
- Essential Role of Water and Lipids in G-Protein-Coupled Receptor Chemistry
Principal Investigator (PI)
2019
$400.0KActive - Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering
Principal Investigator (PI)
2018
$800.0KActive - Ultrafast Protein Dynamics Studied by Time-Resolved Solution X-Ray Scattering
Principal Investigator (PI)
2019
$220.0K - Membrane Basis of Visual Excitation
Principal Investigator (PI)
2016
$1.1M - Regulation of Nonmuscle Myosin Light Chain Kinase Structure and Function of ARDS
Co-Investigator (COI)
2015
$262.1K - Biophysical and Computational Investigation of the Rhodopsin Activation Mechanism
Co-Investigator (COI)
2009
$140.5K - Membrane Interactions and Neurodegeneration in Parkinson's Disease
Co-Investigator (COI)
2009
$48.8K - Membrane Basis of Visual Excitation
Principal Investigator (PI)
2008
$1.4M - Lipid Modulation of Rhodopsin Signaling in Membranes
Principal Investigator (PI)
2008
$1.1M
Technologies / Patents
News
- Black Life Matters Conference to Address Violence
2015
- Why Black Life Matters: A Reflection
2015
- How New Social Movements Take Root
2014
- Four UA Professors Elected as AAAS Fellows
2012
- UA Researcher Wins American Chemical Society Award
2010
- Planetary Astronomer Michael Brown to Give Aaronson Memorial Lecture
2008
- UA Boasts 5 New Fulbright Scholars, Visiting Scholars
2001
Publications (227)
Recent
- How Cholesterol Stiffens Unsaturated Lipid Membranes
2020
- Rhodopsin Activation in Lipid Membranes Based on Solid-State NMR Spectroscopy
2020
- Nicotinamide Phosphoribosyltransferase Purification Using SUMO Expression System
2020
- G-Protein-Coupled Receptor Activation Mediated by Internal Hydration
2019
- Deuterium NMR Spectroscopy in Colloid and Surface Chemistry
2019
- Quantum Mechanical and Molecular Mechanics Modeling of Membrane-Embedded Rhodopsin
2019
- Quasielastic and Elastic Neutron Scattering of Membrane Proteins
2019
- Hydration Modulates G-Protein-Coupled Receptor Signaling
2019
- Structural Fluctuations in Rhodopsin Activation Revealed by Neutron Scattering
2019
- Flexible Lipid Nanomaterials Studied by NMR Spectroscopy
2019
- Retinal Flipping During Rhodopsin Activation Revealed by Solid State 2H NMR and QM/MM Simulations
2019
- Study of Ultra-Fast Rhodopsin Activation Dynamics with Molecular Dynamics Simulations
2019
- Phospholipid Headgroups Govern Emergent Bending Energy of Membranes with Implications for Lipid-Protein Interactions
2019
- Effect of Biopolymer Tethers on Antimicrobial Peptide Activity in Biomembranes
2019
- Cholesterol effects on the physical properties of lipid membranes viewed by solid-state NMR spectroscopy
2019
- Membrane Deformation Under Isotropic External Stress
2019
- Mesoscopic Dynamics in Phospholipid Membranes under Osmotic Stress
2019
- Flexible Surface Model for Lipid-Protein Interactions
2019
- Total synthesis of 9-CD3-9-cis-retinal for studying vision
2019
- Soft Interfaces in Membrane Protein-Lipid Interactions
2019
- Rhodopsin Hydration Dynamics Studied by Solid-State Deuterium NMR Spectroscopy
2019
- Sponge Model of G-Protein Binding and Unbinding in Membranes
2019
- Functional Water Dynamics in Rhodopsin Using Solid-State Deuterium NMR Spectroscopy
2019
- Emergence of Membrane Material Parameters Revealed by Solid-State 2H NMR Spectroscopy
2018
- Small-Angle Neutron Scattering Reveals Energy Landscape For Rhodopsin Photoactivation
2018
- Solid-State 2H NMR Investigations of Viral M2 Ion Channel Drugs
2018
- Synthesis of 9-CD3-9-cis-Retinal Cofactor of Isorhodopsin
2018
- Soft Matter Influences on G-Protein-Coupled-Receptor Activation Probed by FTIR and UV-Visible Spectroscopy
2018
- Dynamics of Membrane Proteins Studied by Solid State 2H NMR Relaxation
2018
- G-Protein-Coupled Receptor Activation through Membrane Deformation
2018
- Hydration Thermodynamics of a Powdered G-Protein-Coupled Receptor
2018
- Emergence of Undulations as 2-D Director Fluctuations in Phospholipid Membranes
2018
- Investigation of Photoinduced Oligomerization of Rhodopsin By Native Mass Spectrometry
2018
- Multiscale GPCR Activation in Lipid Membranes Probed by Solid-State NMR and Scattering Methods
2017
- Concepts and Methods of Deuterium NMR Spectroscopy Applied to Biomembranes
2017
- Energy Landscape and Spatial Motion Models in Rhodopsin Activation
2017
- Hydration-Mediated Elastic Deformations in Biological Membranes
2017
- Activation of GPCR Rhodopsin Investigated by Solid-State NMR Spectroscopy
2017
- Solid-State 2H NMR Studies of Water-Mediated Lipid Membrane Deformation
2017
- Role of Soft Matter in G-Protein-Coupled Receptor Signaling
2017
- Collective Dynamics in Lipid Membranes
2017
- Solid-State Deuterium NMR Spectroscopy of Rhodopsin
2017
- Soft Matter in Lipid-Protein Interactions
2017
- Self-Association and Conformational Stability of NAMPT Protein
2017
- Time-Resolved Wide-Angle X-ray Scattering Reveals Protein Quake in Rhodopsin Activation
2017
- Retinal Chromophore Structure in Meta-II Rhodopsin Revealed by Solid-State 2H NMR and Molecular Modeling
2016
- Thermal Denaturation and Domain Stability of NAMPT Protein
2016
- Neutron Scattering Reveals Protein Fluctuations in GPCR Activation
2016
- Elastic Deformation and Collective Dynamics in Lipid Membranes: A Solid-State 2H NMR Relaxation Study
2016
- Cholesterol-Induced Suppression of Membrane Elastic Fluctuations at the Atomistic Level
2016
- Computational and Experimental Studies of Lipid-Protein Interactions in Biomemrane Function
2016
- Hydration Mediated G-Protein-Coupled Receptor Activation,
2016
- Powdered G-Protein–Coupled Receptors
2016
- Quasi-Elastic Neutron Scattering Reveals Ligand-Induced Protein Dynamics of a G-Protein–Coupled Receptor
2016
- Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. II. Magnetic Resonance Spectroscopy
2016
- Elastic Deformation and Area Per Lipid of Membranes: Atomistic View From Solid-State Deuterium NMR Spectroscopy
2015
- A Usual G-Protein-Coupled Receptor in Unusual Membranes
2015
- Retinal Fliin Rhodopsin Activation?
2015
- Investigation of Rhodopsin Dynamics in its Signaling State by Solid-State Deuterium NMR Spectroscopy
2015
- Spontaneous Reconstitution of Bovine Rhodopsin into Artificial Membranes
2015
- Spectral Methods for Study of the G-Protein-Coupled Receptor Rhodopsin. I. Vibrational and Electronic Spectroscopy
2015
- Small Angle Neutron and X-Ray Scattering Reveal Conformational Differences in Detergents Affecting Rhodopsin Activation
2015
- Membrane-Lipid Mediated Rhodopsin Signaling Involves an Ensemble of Conformational Substates
2015
- Hydration-Modulated Collective Dynamics of Membrane Lipids are Revealed by Solid-State 2H NMR Relaxation
2015
- Solid-State 2H NMR Investigation of Transducin Activation by Rhodopsin
2015
- Rhodopsin Photoactivation Dynamics Revealed by Quasi-Elastic Neutron Scattering
2015
- Ensemble Activation of G-Protein–Coupled Receptors Revealed by Small-Angle Neutron Scattering
2014
- Role of Membrane Lipids in Activating G-Protein-Coupled Receptors
2014
- Generalized Model-Free Spectral Density Analysis Applied to Rhodopsin Activation in Membranes
2014
- Conformational Fluctuations in G-Protein-Coupled Receptors
2014
- Lipid-Mediated Activation of G-Protein-Coupled Receptors in Membranes
2014
- Retinal Makes Concerted Conformational Changes During Early Stages of Rhodopsin Activation
2014
- Area Per Lipid of Membranes from Natural Abundance Solid-State 13C NMR Spectroscopy
2014
- Intermembrane Forces and Membrane Deformation Observed via Dehydration and Osmotic Pressure
2014
- Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy
2014
- Investigation of Lipid Bilayer Effects on Rhodopsin Activation using UV-Visible and FTIR Spectroscopy
2014
- Experimental and Theoretical Comparison of Pressure Effects on Lipid Bilayer Fluctuations
2014
- Generalized Model-Free Analysis of Nuclear Spin Relaxation Experiments
2014
- Phospholipid Bilayer Membranes: Deuterium and Carbon-13 NMR Spectroscopy
2014
- G-Protein-Coupled Receptor Activation Investigated using Small-Angle Neutron Scattering
2014
- Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures
2014
- Membrane Bilayer Environment Influences Thermodynamics of Rhodopsin Membrane Protein-Lipid Interactions
2013
- Solid-state NMR spectroscopy for the physical chemistry laboratory
2013
- High-resolution NMR reveals secondary structure and folding of amino acid transporter from outer chloroplast membrane
2013
- Retinal Conformation Governs pKa of Protonated Schiff Base in Rhodopsin Activation
2013
- Retinal Changes Conformation During the Early Stages of Rhodopsin Activation
2013
- Lipid Bilayer Influences Rhodopsin Activation Probed by FTIR and UV-Visible Spectroscopy
2013
- Restructuring of Membrane Bilayers due to Osmotic Pressure: Deuterium Solid-State NMR Study
2013
- Solid-State 13C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein 945;synuclein
2013
- Area per Lipid and Elastic Deformation of Membrane Bilayers Under Osmotic Stress
2013
- Membrane Structure and Intermembrane Forces Observed with Small Angle X-Ray Scattering
2013
- Activation of rhodopsin based on solid-state NMR spectroscopy
2013
- Model-Free Spectral Density Mapping Applied to Dynamics of Rhodopsin in Solid-State NMR Spectroscopy
2013
- Secondary Structure and Folding of Amino Acid Transporter from Outer Chloroplast Membrane
2013
- Suppression of Cooperative Motions in Phospholipid Membranes by Osmotic Stress: Deuterium NMR Relaxation Study
2013
- Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation
2012
- Membrane Area Deformation under Osmotic Stress: Deuterium NMR Approach
2012
- Curvature forces in membrane lipid-protein interactions
2012
- Rhodopsin Activation is Modulated by Non-Specific Membrane Lipid-Protein Interactions
2012
- The Retinal Energy Landscape as a Function of the Rhodopsin Photocycle
2012
- NMR Studies on Membrane Protein OEP16
2012
- Hydration-Mediated Slow Dynamics in Phospholipid Membranes
2012
- UV-visible and infrared methods for investigating lipid-rhodopsin membrane interactions
2012
- Molecular dynamics simulations reveal specific interactions of post-translational palmitoyl modifications with rhodopsin in membranes
2012
- Rhodopsin Simulations in Detergent Micelles Characterize Meta I and Meta II Photointermediates
2012
- Time-Resolved UV-Visible Studies of Rhodopsin Provide Experimental Test of Flexible Surface Model for Lipid-Protein Interactions
2012
- Flexible Surface Model for Membrane Lipid-Protein Interactions
2012
- Intermembrane Forces Probed by Osmotic Stress and Solid-State 2H NMR Spectroscopy
2012
- Molecular Simulations Illuminate Rhodopsin Activation Based on New Crystal Structures
2012
- Solid-State 2H NMR Reveals Changes in Membrane Flexibility Due to Osmotic Pressure
2012
- Retinal Structural Dynamics in Rhodopsin Activation
2011
- Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin
2011
- An NMR database for simulations of membrane dynamics
2011
- Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation
2011
- Steric and electronic influences on the torsional energy landscape of retinal
2011
- Solid-state 178;H NMR shows equivalence of dehydration and osmotic pressures in lipid membrane deformation
2011
- The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding
2010
- Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: The meta IIa conformational substate
2010
- Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy
2010
- Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small angle x-ray scattering, and molecular theory
2009
- Retinal conformation and dynamics in activation of rhodopsin illuminated by solid-state 2H NMR spectroscopy
2009
- Bolalipid membrane structure revealed by solid-state 2H NMR spectroscopy
2008
- Two protonation switches control rhodopsin activation in membranes
2008
- Fluid mechanical matching of H+ATP synthase subunit c-ring with lipid membranes revealed by 2H solid-state NMR
2008
- Ultra-high vacuum surface analysis study of rhodopsin incorporation into supported lipid bilayers
2008
- Reconstitution of rhodopsin into polymerizable planar supported lipid bilayers: Influence of dienoyl monomer structure on photoactivation
2008
- Raftlike mixtures of sphingomyelin and cholesterol investigated by solid-state 2H NMR spectroscopy
2008
- Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations
2007
- Structural analysis and dynamics of retinal chromophore in dark and meta I states of rhodopsin from 2H NMR of aligned membranes
2007
- Solid-State 2H NMR spectroscopy of retinal proteins in aligned membranes
2007
- Synthesis of CD3-labeled 11-cis-retinals and application to solid-state deuterium NMR spectroscopy of rhodopsin
2007
- X-ray scattering and solid-state deuterium nuclear magnetic resonance probes of structural fluctuations in lipid membranes
2007
- Flexibility of ras lipid modifications studied by 2H solid-state NMR and molecular dynamics simulations
2007
- Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes
2006
- Retinal counterion switch mechanism in vision evaluated by molecular simulations
2006
- Solid-state 2H NMR structure of retinal in metarhodopsin I
2006
- Rhodopsin Reconstituted into a Planar-Supported Lipid Bilayer Retains Photoactivity after Cross-Linking Polymerization of Lipid Monomers
2005
- Lipid modifications of a ras peptide exhibit altered packing and mobility versus host membrane as detected by 2H solid-state NMR
2005
- Phosphatidylethanolamine Enhances Rhodopsin Photoactivation and Transducin Binding in a Solid-Supported Lipid Bilayer as Determined Using Plasmon-Waveguide Resonance Spectroscopy
2005
- Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by 2H NMR and X-ray diffraction
2005
- Perturbation of the hydrophobic core of lipid bilayers by the human antimicrobial peptide LL-37
2004
- Deuterium NMR structure of retinal in the ground state of rhodopsin
2004
- Membrane Model for the G-Protein-Coupled Receptor Rhodopsin: Hydrophobic Interface and Dynamical Structure
2004
- Lanosterol and Cholesterol-Induced Variations in Bilayer Elasticity Probed by 2H NMR Relaxation
2004
- NMR Solution Structure of the Glucagon Antagonist desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles
2003
- NMR elastometry of fluid membranes in the mesoscopic regime
2002
- Elastic deformation of membrane bilayers probed by deuterium NMR relaxation
2002
- Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by 2H NMR and molecular dynamics simulations
2002
- Anisotropic motion and molecular dynamics of cholesterol, lanosterol, and ergosterol in lecithin bilayers studied by quasi-elastic neutron scattering
2002
- Electrostatic properties of membrane lipids coupled to metarhodopsin II formation in visual transduction
2002
- Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids
2002
- Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy
2001
- Composite membrane deformation on the mesoscopic length scale
2001
- Area per lipid and acyl length distributions in fluid phosphatidylcholines determined by 2H NMR spectroscopy
2000
- Softening of membrane bilayers by detergents elucidated by deuterium NMR spectroscopy
2000
- Solid-state NMR line shapes of uniaxially oriented immobile systems
1999
- Thermotropic Behavior of Lipophilic Derivatized 60]Fullerenes Studied by Deuterium NMR, X-ray Diffraction, and Microcalorimetry
1999
- Structures and synthesis of 4a-homo-7,19-dinorsteroids, X-ray crystallography and NMR spectroscopy
1999
- Plasmon resonance spectroscopy: Probing molecular interactions within membranes
1999
- 2H-NMR in liquid crystals and membranes
1999
- The angles between the C1- C5- and C9-methyl bonds of the retinylidene chromophore and the membrane normal increase in the M intermediate of bacteriorhodopsin: Direct determination with solid-state 2H NMR
1999
- Influence of Cholesterol on Dynamics of Dimyristoylphosphatidylcholine Bilayers as Studied by Deuterium NMR Relaxation
1999
- Lipid Bilayer Dynamics from Simultaneous Analysis of Orientation and Frequency Dependence of Deuterium Spin-Lattice and Quadrupolar Order Relaxation
1998
- Structure of the A-form and B-form of DNA from deuterium NMR line shape simulation
1998
- Chromophore orientation in bacteriorhodopsin determined from the angular dependence of deuterium nuclear magnetic resonance spectra of oriented purple membranes
1998
- Influence of Nonlamellar-Forming Lipids on Rhodopsin
1997
- Correlation Functions for Lipid Membrane Fluctuations Obtained from NMR Spectroscopy
1997
- Dynamics of lipid bilayers from comparative analysis of 2H and 13C nuclear magnetic resonance relaxation data as a function of frequency and temperature
1997
- 1H-125Te} Indirect Detection in Nuclear Magnetic Resonance Spectra of Organotellurium Compounds
1997
- Surface plasmon resonance spectroscopy studies of membrane proteins: Transducin binding and activation by rhodopsin monitored in thin membrane films
1996
- Fast field-cycling nuclear magnetic resonance spectrometer
1996
- Molecular Dynamics of Vesicles of Unsaturated Phosphatidylcholines Studied by 13C NMR Spin-Lattice Relaxation
1995
- Indirect Detection of Selenium-77 in Nuclear Magnetic Resonance Spectra of Organoselenium Compounds
1995
- Modulation of rhodopsin function by properties of the membrane bilayer
1994
- Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: A wide-line deuterium and phosphorus-31 NMR study
1994
- Angular Dependence of Deuterium Spin-Lattice Relaxation of Dilaurylphosphatidylcholine in the Liquid-Crystalline Phase
1994
- Conformational Changes in Rhodopsin Probed by Surface Plasmon Resonance Spectroscopy
1994
- A personal computer-based nuclear magnetic resonance spectrometer
1994
- Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy
1993
- Lipid headgrouand acyl chain composition modulate the MI-MII equilibrium of rhodopsin in recombinant membranes
1993
- Photoinduced destabilization of liposomes
1992
- 31P NMR and X-ray diffraction study of the effect of photopolymerization on lipid polymorphism
1992
- Detection of atherosclerosis via magnetic resonance imaging
1992
- Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine
1992
- Effect of bile salts on monolayer curvature of a phosphatidylethanolamine/water model membrane system
1991
- Bilayers of Arachidonic Acid Containing Phospholipids Studied By 2H and 31P NMR Spectroscopy
1991
- Molecular areas of phospholipids as determined by 2H NMR spectroscopy. Comparison of phosphatidylethanolamines and phosphatidylcholines
1991
- Membrane lipid influences on the energetics of the metarhodopsin I and metarhodopsin II conformational states of rhodopsin probed by flash photolysis.
1991
- Low Temperature 2H NMR Spectroscopy of Phospholipid Bilayers Containing Docosahexaenoyl 22:6&969;3) Chains
1991
- Role of phosphatidylserine in the MI-MIII equilibrium of rhodopsin
1991
- Magnetic resonance imaging of lipid deposits in human atheroma via a stimulated-echo diffusion-weighted technique
1991
- Influence of pH on the MI-MII equilibrium of rhodopsin in recombinant membranes
1990
- Magnetic Alignment and Orientational Order of Dipalmitoylphosphatidylcholine Bilayers Containing Palmitoyllyso-phosphatidylcholine
1990
- Frequency Dependent 2H N.M.R. Relaxation Rates of Small Unilamellar Vesicles
1990
- Orientational anisotropy of nuclear spin relaxation in phospholipid membranes
1990
- Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy
1990
- High-resolution 1H NMR spectral signature from human atheroma
1988
- Identification and 3-D quantification of atherosclerosis using magnetic resonance imaging
1988
- Lipid-protein interactions mediate the photochemical function of rhodopsin
1988
- High-resolution proton NMR spectra of human arterial plaque
1987
- Configurational statistics of acyl chains in polyunsaturated lipid bilayers from 2H NMR
1987
- Erratum: 31P NMR spectra of rod outer segment and sarcoplasmic reticulum membranes show no evidence of immobilized components due to lipid-protein interactions Biochemistry 1986) 25:13 3742-3748)
1986
- Frequency dependence of spin-lattice relaxation times of lipid bilayers
1985
- Membrane NMR: a dynamic research area
1985
- Thermotropic behavior of retinal rod membranes and dispersions of extracted phospholipids
1985
- Dependence of deuterium spin-lattice relaxation rates of multilamellar phospholipid dispersions on orientational order
1985
- 14N NMR of lipid bilayers: Effects of ions and anesthetics
1984
- The quadrupolar spectrum of a spin I 1 in a lipid bilayer in the presence of paramagnetic ions
1984
- Unified picture for spin-lattice relaxation of lipid bilayers and biomembranes
1983
- New view of lipid bilayer dynamics from 2H and 13C NMR relaxation time measurements
1983
- Theory of spin-lattice relaxation in lipid bilayers and biological membranes. Dipolar relaxation
1983
- Lipid bilayer dynamics and rhodopsin-lipid interactions: New approach using high-resolution solid-state 13C NMR
1983
- Proton, carbon-13, and phosphorus-31 NMR methods for the investigation of rhodopsin-lipid interactions in retinal rod outer segment membranes
1982
- Theory of spin-lattice relaxation in lipid bilayers and biological membranes. 2H and 14N quadrupolar relaxation
1982
- Retinal rod outer segment lipids form bilayers in the presence and absence of rhodopsin: a 31P NMR study
1981
- Orientation and frequency dependence of the deuterium spin-lattice relaxation in multilamellar phospholipid dispersions: implications for dynamic models of membrane structure
1981
- Histidyl and tyrosyl residue ionization studies of subtilisin novo
1979
- Structural dynamics in phospholipid bilayers from deuterium spin-lattice relaxation time measurements
1979
- Deuterium relaxation and molecular dynamics in lipid bilayers
1979
- Influence of cholesterol on the polar region of phosphatidylcholine and phosphatidylethanolamine bilayers
1978
- Quenching of the tyrosyl and tryptophyl fluorescence of subtilisins Carlsberg and Novo by iodide
1977
- Proton spin lattice relaxation of retinal rod outer segment membranes and liposomes of extracted phospholipids
1977
- Resolution of independently titrating spectral components of the ultraviolet circular dichroism of subtilisin enzymes by matrix rank analysis
1977
- Interpretation of 100- and 360-MHz proton magnetic resonance spectra of retinal rod outer segment disk membranes
1977
- Ion-induced changes in head grouconformation of lecithin bilayers
1977
- 1H-NMR studies of protein-lipid interactions in retinal rod outer segment disc membranes
1976
- Circular dichroism and gel filtration behavior of subtilisin enzymes in concentrated solutions of guanidine hydrochloride
1975
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