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Picture of Jil Tardiff

Jil Tardiff

Professor, BIO5 Institute | Professor, Biomedical Engineering | Professor, Physiological Sciences - GIDP | Professor, Medicine | Member of the Graduate Faculty | Professor, Cellular and Molecular Medicine

Biomedical Engineering

Collaboration(24)

John Konhilas
Paul Langlais
Elizabeth Juneman
Ryan Sprissler
Edward Bedrick

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Grants(22)

Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation
Active·2024·$31.9K / $638.2K·
External
Co-Investigator (COI)
cardiac, myosin, protein, structural dynamics, regulation
Sex-specific Myofilament Dysfunction in Postmenopausal HFpEF
Active·2023·$0 / $447.8K·
External
Key Personnel (KP)
cardiovascular disease, myocardial dysfunction, gender differences, postmenopausal health, myofilament dysfunction
Blunting of the Myofilament Beta-Adrenergic Response in HCM: Structural-Dynamic Mechanisms
Active·2023·$85K·
External
Co-Investigator (COI)
cardiomyopathy, myofilament, beta-adrenergic, structural dynamics, biomedical research
Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics
Active·2022·$172.4K / $1.4M·
External
Co-Investigator (COI)
muscle regulation, protein structure, skeletal muscle dynamics, cardiac muscle function, sarcomere organization
Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics
Active·2022·$0 / $122K·
External
Co-Investigator (COI)
muscle regulation, protein structure, skeletal muscle dynamics, cardiac muscle function, sarcomere organization

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Publications(143)

Recent

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different Mutations

2022

genotype, atrial fibrillation, hypertrophic cardiomyopathy, pathogenesis, mutations

Sex‐Related Differences in Genetic Cardiomyopathies

2022

genetic cardiomyopathies, sex differences, genetics, cardiovascular diseases, gender disparities

Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics

2022

cardiomyopathies, genetics, disease mechanisms, therapeutics, emerging treatments

Targeted therapies for cardiac diseases

2022

cardiac diseases, targeted therapies, cardiovascular research, precision medicine, drug development

Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure

2022

myosin modulators, cardiomyopathies, heart failure

Insights into the Mechanism of the Cardiac Drug Omecamtiv Mecarbil─A Computational Study

2022

cardiac drugs, mechanism, omecamtiv mecarbil, cardiac health

Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament

2022

protein structure, cardiac physiology, molecular dynamics, muscle contraction, biophysical studies

Free-Energy Surfaces of Two Cardiac Thin Filament Conformational Changes during Muscle Contraction

2022

cardiac muscle contraction, protein conformation, free-energy surfaces, thin filament, muscle mechanics

A Proposed Mechanism for the Initial Myosin Binding Event on the Cardiac Thin Filament: A Metadynamics Study

2021

cardiac muscle, molecular dynamics, myosin binding, muscle contraction, biophysical interactions

Mapping the Cardiac Troponin T Linker Region to Actin and Determining Pathogenic Point Mutational Effects

2021

cardiac troponin t, actin, mutational effects, pathogenic, mapping