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Picture of Jil Tardiff

Jil Tardiff

Professor, Physiological Sciences - GIDP | Professor, Medicine | Professor, Cellular and Molecular Medicine | Professor, Biomedical Engineering | Professor, BIO5 Institute | Member of the Graduate Faculty

Biomedical Engineering

Collaboration(19)

Patrick Wightman
John Konhilas
Jennifer Barton
Edward Bedrick
Paul Langlais

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Grants(23)

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Publications(143)

Recent

Insights into the Mechanism of the Cardiac Drug Omecamtiv Mecarbil─A Computational Study

2022

cardiac drugs, mechanism, omecamtiv mecarbil, cardiac health

Structure and Dynamics of the Flexible Cardiac Troponin T Linker Domain in a Fully Reconstituted Thin Filament

2022

protein structure, cardiac physiology, molecular dynamics, muscle contraction, biophysical studies

Sex‐Related Differences in Genetic Cardiomyopathies

2022

genetic cardiomyopathies, sex differences, genetics, cardiovascular diseases, gender disparities

Targeted therapies for cardiac diseases

2022

cardiac diseases, targeted therapies, cardiovascular research, precision medicine, drug development

Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure

2022

myosin modulators, cardiomyopathies, heart failure

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different Mutations

2022

genotype, atrial fibrillation, hypertrophic cardiomyopathy, pathogenesis, mutations

Thin filament cardiomyopathies: A review of genetics, disease mechanisms, and emerging therapeutics

2022

cardiomyopathies, genetics, disease mechanisms, therapeutics, emerging treatments

Free-Energy Surfaces of Two Cardiac Thin Filament Conformational Changes during Muscle Contraction

2022

cardiac muscle contraction, protein conformation, free-energy surfaces, thin filament, muscle mechanics

Mapping the Cardiac Troponin T Linker Region to Actin and Determining Pathogenic Point Mutational Effects

2021

cardiac troponin t, actin, mutational effects, pathogenic, mapping

Exploring the Effects of Mutations and Thick Filament Proteins on Myofilament Calcium Kinetics Via Stopped-Flow

2021

genetic mutations, protein interactions, muscle contraction, biochemical kinetics, experimental techniques