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Jennifer Barton, Ph.D. is known for her development of miniature endoscopes that combine multiple optical imaging techniques, particularly optical coherence tomography and fluorescence spectroscopy. She evaluates the suitability of these endoscopic techniques for detecting early cancer development in patients and pre-clinical models. She has a particular interest in the early detection of ovarian cancer, the most deadly gynecological malignancy. Additionally, her research into light-tissue interaction and dynamic optical properties of blood laid the groundwork for a novel therapeutic laser to treat disorders of the skin’s blood vessels. She has published over 100 peer-reviewed journal papers in these research areas. She is currently Professor of Biomedical Engineering, Electrical and Computer Engineering, Optical Sciences, Agriculture-Biosystems Engineering, and Medical Imaging at the University of Arizona. She has served as department head of Biomedical Engineering, Associate Vice President for Research, and is currently Director of the BIO5 Institute, a collaborative research institute dedicated to solving complex biology-based problems affecting humanity. She is a fellow of SPIE – the International Optics Society, and a fellow of the American Institute for Medical and Biological Engineering. Keywords: bioimaging, biomedical optics, biomedical engineering, bioengineering, cancer, endoscopesShow Less
VOSviewer
Courses
- MDABEMeasurement and Data Analysis in Biomedical Engineering
- BOBBiomedical Optics and Biophotonics
Grants
- Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
Principal Investigator (PI)
2022
$1.7M
Active - WARE-Care: A Novel RF-Based System to Assess and Prevent Falling
Co-Investigator (COI)
2022
$220.5K
Active - Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
Principal Investigator (PI)
2022
$97.1K
Active - MRI: Development of Integrated Multi-Access Entangled Photon Sources and Single-Photon Detector Array Instrument for Interdisciplinary Quantum Information Research
Co-Investigator (COI)
2018
$1000.0K
Active - Optical Imaging Falloposcope for Early Ovarian Cancer Detection: In Vivo Feasibility and Safety
Principal Investigator (PI)
2018
$862.5K
Active - Outpatient Screening for Early-Stage High-Grade Serous Ovarian Cancer in Higher Risk Women
Principal Investigator (PI)
2021
$39.8K
- Development of In Vitro Diagnostic Multivariate Index Assay Using Liquid-Based Cervical Cytology Specimen and/or Serum/Plasma Biomarkers for the Detection of Early Stage or Low-Volume Ovarian Cancer
Principal Investigator (PI)
2019
$186.5K
- Furthering the Foundation of Clinical Optical Biopsies
Co-Investigator (COI)
2019
$30.0K
- Combined optical coherence tomography and autofluorescence imaging for screening of early-stage esophageal cancer
Principal Investigator (PI)
2019
$5.0K
- Molecular and Imaging Assessment of Fallopian Tube Health
Principal Investigator (PI)
2018
$385.2K
Technologies / Patents
Books
- Combined Endoscopic Optical Coherence Tomography and Laser Induced Fluorescence in Optical Coherence Tomography: Technology and Applications , Drexler and Fujimoto
2015
News
- Tapping into technology to improve health care research
2022
- Researchers pilot 'itty bitty' device for earlier ovarian cancer detection
2022
- Trading Pipets for Keyboards: KEYS Internship Goes Virtual
2020
- UArizona Researchers Pivot to Tackle COVID-19
2020
- I-Squared Awards Honor Researchers and Technology Champions
2019
- Interdisciplinary UA Researchers Get Tangled Up in Quantum Computing
2019
- Novel Study Could Help Treat, Diagnosis, Prevent Cervical Cancer
2019
- Stopping Cancer With a Smartphone
2018
- $1.5M Gift to UA to Help Shape Biomedical Engineers of Tomorrow
2018
- Tucson Festival of Books to Celebrate 10th Anniversary
2018
- UA Researchers Make Next Move in Fight Against Ovarian Cancer
2018
- Giving Students the KEYS to STEM Success
2018
- Celebrating Women in Medicine Month with Felicia Goodrum
2018
- KEYS Program Pairs Young Scientists With UA Research Mentors
2017
- UA Researcher Gets Grant for Ovarian Cancer Screening Device
2016
- UA Engineers Zero In on Ovarian Cancer
2016
- Barton Named Interim Director of BIO5
2015
- New Technology May Help Surgeons Save Lives
2015
- UA Ranked Second in the Nation for Physical Sciences Research Funding
2014
- UA Launches Defense and Security Research Institute
2014
- Photo Essay: UA Training the Next Generation of STEM Specialists
2014
- American Indian Studies Becomes Department, Plans to Offer Bachelor's Degree
2014
- Graduate Interdisciplinary Programs Build Collaboration, Productivity
2013
- Grant to Fuel Baking Soda Cancer Therapy Research
2012
- UA a Big Winner at AZBio Awards
2012
- New Technology Helps Patients Suffering Joint Damage
2012
- Open Access Week 2012: Raising Awareness at the UA
2012
- Electrical and Computer Engineering Celebrates 100 Years
2010
- Researchers Honored at Innovation Day
2009
- Innovation Day Exhibitor Deadline Approaching
2009
- Research Team Designing Holographic Imaging System for Ovarian Cancer
2009
- BIO5 Names New Associate, Assistant Directors
2009
- BIO5 to Host 7th Arizona Biosciences Leadership Symposium
2008
- Research Pushes Back Threshold of Early Cancer Detection
2008
- Society for Optical Engineering Monthly Planner Features Two UA Professors
2005
- Biomedical Engineers Developing Better, More Sensitive Way to Detect Pre-cancers
2002
- Under The Skin
1999
Publications (131)
Recent
- Ovarian Cancer Detection Using Optical Coherence Tomography and Convolutional Neural Networks
2022
- Study of fallopian tube anatomy and mechanical properties to determine pressure limits for endoscopic exploration
2022
- Using FDA-approved drugs as off-label fluorescent dyes for optical biopsies: from in silico design toproof-of-concept
2021
- Sub-millimeter endoscope demonstrates feasibility of in vivo reflectance imaging, fluorescence imaging, and cell collection in the fallopian tubes
2021
- Effect of an Added Mass on the Vibration Characteristics for Raster Scanning of a Cantilevered Optical Fiber
2021
- Triple-modality co-registered endoscope featuring wide-field reflectance imaging, and high-resolution multiphoton and optical coherence microscopy
2021
- Karyometry Identifies a Distinguishing Fallopian Tube Epithelium Phenotype in Subjects at High Risk for Ovarian Cancer
2021
- Falloposcope Modifications for Clinical Trials
2020
- Use of embedded and patterned dichroic surfaces with reflective optical power to enable multiple optical paths in a micro-objective
2020
- Reengineering a falloposcope imaging system for clinical use
2020
- Fluorescence and Multiphoton Imaging for Tissue Characterization of a Model of Postmenopausal Ovarian Cancer
2020
- Using customized computational analyses to evaluate the feasibility and risk of endoscopes with an SNR analysis as an example (Conference Presentation)
2020
- Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue
2019
- 3D printed lens for depth of field imaging
2019
- Comparison of Reproductive Function in Female Transgenic and Wildtype C57BL/6 Mice
2019
- Insight into the mechanisms of type III minocycline-induced pigmentation removal: A case of repeated immediate pigment clearing with the Q-switched 755-nm alexandrite laser over a 13-year period
2019
- Quantification of multiphoton and fluorescence images of reproductive tissues from a mouse ovarian cancer model shows promise for early disease detection
2019
- Watt-level all-fiber optical parametric chirped-pulse amplifier working at 1300 nm
2019
- Comparison of Markers of Reproductive Function in Female C57Bl/6 versus TgMISIIR-TAg Transgenic Mice: Effect of VCD exposure on Ovarian Failure.
2018
- All-fiber dissipative soliton Raman laser based on phosphosilicate fiber
2018
- Compact fiber-based multi-photon endoscope working at 1700 nm
2018
- Does Mutated K-RAS Oncogene Attenuate the Effect of Sulindac in Colon Cancer Chemoprevention?
2018
- Three-dimensional texture analysis of optical coherence tomography images of ovarian tissue
2018
- Volume holographic imaging endoscopic design and construction techniques
2017
- Wavelength-coded volume holographic imaging endoscope for multidepth imaging
2017
- In vivo endoscopic Doppler optical coherence tomography imaging of the colon
2017
- Design and characterization of a combined OCT and wide field imaging falloposcope for ovarian cancer detection
2017
- Ultraminiature optical design for multispectral fluorescence imaging endoscopes
2017
- Intermittent Dosing with Sulindac Provides Effective Colorectal Cancer Chemoprevention in the Azoxymethane-Treated Mouse Model
2017
- Three-photon imaging of ovarian cancer
2016
- Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts
2016
- Design of an everting balloon to deploy a microendoscope to the fallopian tubes.
2016
- Optical coherence tomography imaging of colonic crypts in a mouse model of colorectal cancer
2016
- Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early-stage cancer detection
2016
- Multispectral fluorescence imaging of human ovarian and Fallopian tube tissue for early stage cancer detection
2015
- In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis
2015
- Stray light mitigation in a novel endoscope for fallopian tubes
2015
- A six-color four-laser mobile platform for Multi-spectral Fluorescence Imaging Endoscopy
2015
- Using optical coherence tomography to examine additives in Chinese Song Jun glaze
2015
- In vivo molecular imaging of colorectal cancer using quantum dots targeted to vascular endothelial growth factor receptor 2 and optical coherence tomography/laser-induced fluorescence dual-modality imaging
2015
- Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography
2015
- Dual optical modality endoscopic imaging of cancer development in the mouse colon
2015
- Multispectral fluorescence imaging of human ovarian and fallopian tube tissue for early stage cancer detection (abstract)
2015
- MILD TEMPERATURE HYPERTHERMIA INDUCING DOPPLER OPTICAL COHERENCE TOMOGRAPHY ENDOSCOPE FOR EARLY DETECTION OF COLORECTAL CANCER IN A MOUSE MODEL
2015
- Expanding Functionality of Commercial Optical Coherence Tomography Systems by Integrating a Custom Endoscope
2015
- OPTICAL IMAGING FALLOPOSCOPE FOR MINIMALLY INVASIVE OVARIAN CANCER DETECTION
2014
- Healing Tissue Response with ITU (Intense Therapy Ultrasound) in Musculoskeletal Tissue, Feasibility Study
2014
- Quantum dots targeted to vascular endothelial growth factor receptor 2 as a contrast agent for the detection of colorectal cancer
2014
- Simultaneous multiplane imaging of human ovarian cancer by volume holographic imaging
2014
- Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system
2014
- FEASIBILITY OF MODULATING HEALING TISSUE RESPONSE BY ITU (INTENSE THERAPY ULTRASOUND) IN MUSCULOSKELETAL TISSUE
2014
- Optical design of an optical coherence tomography and multispectral fluorescence imaging endoscope to detect early stage ovarian cancer
2014
- Objective assessment of multimodality optical coherence tomography and second-harmonic generation image quality of ex vivo mouse ovaries using human observers
2014
- In vivo time-serial multi-modality optical imaging in a mouse model of ovarian tumorigenesis
2014
- Diagnostic potential of multimodal imaging of ovarian tissue using optical coherence tomography and second-harmonic generation microscopy
2014
- DUAL-MODALITY ENDOSCOPIC IMAGING OF CANCER IN MOUSE COLON
2014
- Volume Holographic Reflection Endoscope for In-Vivo Ovarian Cancer Clinical Studies
2014
- Spiral-scanning, side-viewing optical coherence tomography endoscope for three-dimensional fully sampled in vivo imaging of the mouse colon
2013
- Fluorescence-based SMC and OCT endoscope to study aberrant crypt foci in the mouse colon
2013
- 7,12-dimethylbenz[a]anthracene-induced malignancies in a mouse model of menopause
2013
- In vivo three-dimensional optical coherence tomography and multiphoton microscopy in a mouse model of ovarian neoplasia
2013
- Two-photon excited fluorescence imaging of endogenous contrast in a mouse model of ovarian cancer
2013
- Analysis of second-harmonic-generation microscopy in a mouse model of ovarian carcinoma
2012
- Endoscopic spectral domain optical coherence tomography of murine colonic morphology to determine effectiveness of chemopreventive and chemotherapeutic agents in colorectal cancer
2012
- Analysis of Second-Harmonic Generation Microscopy in a Mouse Model of Ovarian Carcinoma
2012
- Fluorescence-based surface magnifying chromoendoscopy and optical coherence tomography endoscope
2012
- Using optical coherence tomography to characterize thick-glaze structure: Chinese Southern Song Guan glaze case study
2012
- Multi-modality optical imaging of ovarian cancer in post-menopausal mouse model
2011
- Optical polarimetry for noninvasive glucose sensing enabled by Sagnac interferometry
2011
- Ultrahigh resolution all-reflective optical coherence tomography system with a compact fiber-based supercontinuum source
2011
- Novel focused OCT-LIF endoscope
2011
- Feasibility of optical coherence tomography imaging to characterize renal neoplasms: limitations in resolution and depth of penetration
2011
- Spatial-spectral volume holographic systems: resolution dependence on effective thickness
2011
- Volume Holographic Spectral-Spatial Imaging of Biological Tissue
2011
- Analysis of diffracted image patterns from volume holographic imaging systems and applications to image processing
2011
- In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
2011
- Phase-contrast volume holographic imaging system
2011
- Confocal-rainbow volume holographic imaging system
2011
- New Scheme for Polarimetric Glucose Sensing without Polarizers
2010
- 7,12-Dimethylbenz[A]Anthracene Induces Sertoli-Leydig-Cell Tumors in the Follicle-Depleted Ovaries of Mice Treated with 4-Vinylcyclohexene Diepoxide
2010
- Optical Design for a Spatial-Spectral Volume Holographic Imaging System
2010
- Simulations and experiments of aperiodic and multiplexed gratings in volume holographic imaging systems
2010
- Focused OCT and LIF Endoscope
2010
- Simultaneous optical coherence tomography and laser induced fluorescence imaging in rat model of ovarian carcinogenesis
2010
- Ovarian neoplasm development by 7,12-dimethylbenz[a]anthracene (DMBA) in a chemically-induced rat model of ovarian failure
2009
- Automated contact lens measurement using optical coherence tomography
2009
- Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis
2009
- A concentric three element radial scanning optical coherence tomography endoscope
2009
- Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice
2009
- Design of a Handheld Optical Coherence Microscopy Endoscope
2009
- Laparoscopic optical coherence tomography imaging of human ovarian cancer
2009
- In vivo imaging using a VEGF-based near-infrared fluorescent probe for early cancer diagnosis in the AOM-treated mouse model
2009
- Laser-induced fluorescence imaging of subsurface tissue structures with a volume holographic spatial-spectral imaging system
2008
- Inherent homogenous media dispersion compensation in frequency domain optical coherence tomography by accurate k-sampling
2008
- Imaging stented tissue engineered blood vessel mimics
2008
- Scatter sensitive microscopic techniques to identify contrasting mucosal structures in ultrahigh-resolution optical coherence tomograms of mouse colon
2008
- Use of hyperosmotic chemical agent to improve the laser treatment of cutaneous vascular lesions
2008
- Biodegradable plasmon resonant nanoshells
2008
- Fiber array fabrication technique for 15-mu m-diameter single-mode fibers
2008
- Multiplexing volume holographic gratings for a spectral-spatial imaging system
2008
- Laparoscopic optical coherence tomographic imaging of human ovarian cancer
2008
- An automatic algorithm for detecting stent endothelialization from volumetric optical coherence tomography datasets
2008
- Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents
2008
- Fluorescent and scattering contrast agents in a mouse model of colorectal cancer
2008
- Optimization of multiplexed holographic gratings in PQ-PMMA for spectral-spatial imaging filters
2008
- Biophotonics - Big images small features
2007
- Automatic segmentation of cell nuclei in bladder and skin tissue for karyometric analysis - art. no. 66330V
2007
- Using methemoglobin as a magnetic resonance imaging contrast agent
2007
- Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography
2007
- Simultaneous optical coherence and multiphoton microscopy of skin-equivalent tissue models - art. no. 66270X
2007
- Ex vivo optical coherence tomography and laser-induced fluorescence spectroscopy imaging of murine gastrointestinal tract
2007
- Using optical coherence tomography to evaluate skin sun damage and precancer
2007
- Optical coherence tomography with plasmon resonant nanorods of gold
2007
- Serial endoscopy in azoxymethane treated mice using ultra-high resolution optical coherence tomography - art. no. 643208
2007
- Imaging stented blood vessel mimics with optical coherence tomography
2007
- Coupling and cross-talk effects in 12-15 microm diameter single-mode fiber arrays for simultaneous transmission and photon collection from scattering media
2007
- Optical coherence and multiphoton microscopy of skin-equivalent tissue models
2007
- Parallel optical coherence tomography system
2007
- Texture analysis of speckle in optical coherence tomography images of tissue phantoms
2006
- Tissue-engineered vascular grafts as in vitro blood vessel mimics for the evaluation of endothelialization of intravascular devices
2006
- Task-based imaging of colon cancer in the Apc(Min/+) mouse model
2006
- In vivo ultrahigh-resolution optical coherence tomography of mouse colon with an achromatized endoscope
2006
- Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model
2006
- Quantitative evaluation of optical coherence tomography signal enhancement with gold nanoshells
2006
- Nanoshells as contrast agents for scatter-based optical imaging
2006
- Effects of pulsation frequency and endothelial integrity on enhanced arterial transmural filtration produced by pulsatile pressure
2005
- Analog CMOS circuit design and characterization for optical coherence tomography signal processing
2004
- Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement
2004
- Texture analysis of optical coherence tomography images: feasibility for tissue classification
2003
- Recruitment of tendon crimp with applied tensile strain
2002