KMap
Courses
  • BC
    Bioanalytical Chemistry

  • AS
    Analytical Separations

  • IA
    Instrumental Analysis

  • AC
    Analytical Chemistry

  • AAC
    Advanced Analytical Chemistry Laboratory

Student Thesis/Dissertation
  • New Instrumentation and Methods for Analyzing Biological Compounds for Drug Discovery and Discovering Novel Disease Markers

    2018

    doctoral
  • Developing Nanoparticle-Based Platforms for Applications in Nanosensing and Bioanalyses

    2018

    doctoral
  • New Approaches to Advance Ion Channel Sensor Development

    2018

    doctoral
  • Development of Bioanalytical Assays Using Scintillant Polymer-Core Silica-Shell Nanoparticles

    2018

    doctoral
  • I. Development of Rapid Conductance-Based Protocols for Measuring Ion Channel Activity; II. Expression, Characterization, and Purification of the ATP-Sensitive, Inwardly-Rectifying K+ Channel, Kir6.2, and Ion Channel-Coupled Receptors

    2017

    doctoral
  • Development of Novel Separation and Sensor Platforms Based on Polymerized Phospholipid Vesicles

    2016

    doctoral
  • Fabrication of Polystyrene Core-Silica Shell Nanoparticles for Scintillation Proximity Assay (SPA) Biosensors

    2015

    masters
  • Cell-Free Expression of M2Kir6.2 ICCR for Direct Reconstitution into Micropipette Suspended Black Lipid Membranes

    2015

    masters
  • Identification and Validation of Protein Biomarkers for Invasive Aspergillosis; Development of Surface-Induced Dissociation Device and Paper Spray Ionization Source for Protein Complex Studies

    2015

    doctoral
Grants
  • Funding agency logo
    Label Free, Biomimetic Sensors for Hormones and Neurotransmitters

    Principal Investigator (PI)

    2020

    $600.0K
    Active
  • Funding agency logo
    I-Corps: Scintillating Nanoparticles for Low Energy Radioisotope Analytical Workflows

    Principal Investigator (PI)

    2020

    $50.0K
  • Funding agency logo
    Core-Shell Nanoparticles for Direct Detection of Radioisotopes in Aqueous Environments

    Principal Investigator (PI)

    2018

    $360.0K
  • Funding agency logo
    Bio/Chemical Mapping of Pancreatic Cell Activity

    Principal Investigator (PI)

    2016

    $174.2K
  • Funding agency logo
    Nanoshell Sensors For Cellular Analysis

    Principal Investigator (PI)

    2015

    $1.2M
  • Funding agency logo
    Hybrid nanomaterials for dynamic, intracellular radioisotope detection

    Principal Investigator (PI)

    2014

    $388.3K
  • Funding agency logo
    Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes

    Co-Investigator (COI)

    2012

    $1.6M
  • Funding agency logo
    Stabilized Biomimetic Separation Media

    Principal Investigator (PI)

    2011

    $1.1M
  • Funding agency logo
    Ion Channel/Membrane Arrays on Electroactive Waveguides for Biomolecular Assays

    Co-Investigator (COI)

    2006

    $1.9M
  • Funding agency logo
    Career: Cross-Linked Phospholipid Nanosensors for Intracellular Investigations

    Principal Investigator (PI)

    2006

    $548.1K
Technologies / Patents
      News
      • UA Sets Record With 284 Inventions Disclosed in FY 2019

        2019

      • Developing a High-Resolution Picture of Disease Biology

        2019

      • Four UA Students Named Goldwater Scholars

        2010

      • Spying on a Cell - New Nanosensors a Body Can Live With

        2004

      • UA Chemist Probes Cells for Causes of Diabetes

        2003

      Publications (64)
      Recent
      • Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs

        2023

      • Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry

        2022

      • Quantification of intracellular HNO delivery with capillary zone electrophoresis

        2022

      • Direct interaction of the ATP-sensitive K+ channel by the tyrosine kinase inhibitors imatinib, sunitinib and nilotinib

        2021

      • Nanomechanical properties of artificial lipid bilayers composed of fluid and polymerizable lipids

        2021

      • Surface Modification of Glass/PDMS Microfluidic Valve Assemblies Enhances Valve Electrical Resistance

        2019

      • Nanodomain Formation in Planar Supported Lipid Bilayers Composed of Fluid and Polymerized Dienoyl Lipids

        2019

      • Hybrid Nanoparticle Platform for Nanoscale Scintillation Proximity Assay

        2019

      • Expression, purification, and electrophysiological characterization of a recombinant, fluorescent Kir6.2 in mammalian cells

        2018

      • Enhanced Fluorescent Protein Activity in Polymer Scaffold-Stabilized Phospholipid Nanoshells Using Neutral Redox Initiator Polymerization Conditions

        2018

      • Polystyrene-Core, Silica-Shell Scintillant Nanoparticles for Low-Energy Radionuclide Quantification in Aqueous Media

        2018

      • Rapid formation of polymer frits in fused silica capillaries using spatially defined thermal free-radical initiated polymerization

        2018

      • Enhanced Temporal Resolution with Ion Channel-Functionalized Sensors Using a Conductance-Based Measurement Protocol

        2017

      • Fate of fluorescent core-shell silica nanoparticles during simulated secondary wastewater treatment

        2015

      • Aptamer-functionalized porous phospholipid nanoshells for direct measurement of Hg(2+ in urine

        2015

      • Methacrylate Polymer Scaffolding Enhances the Stability of Suspended Lipid Bilayers for Ion Channel Recordings and Biosensor Development

        2015

      • Highly stabilized, polymer-lipid membranes prepared on silica microparticles as stationary phases for capillary chromatography

        2015

      • Ion channel probes for scanning ion conductance microscopy

        2014

      • Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors

        2014

      • Hybrid phospholipid bilayer coatings for separations of cationic proteins in capillary zone electrophoresis

        2014

      • Stabilized phospholipid membranes in chromatography: toward membrane protein-functionalized stationary phases

        2014

      • Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

        2014

      • Practical considerations for preparing polymerized phospholipid bilayer capillary coatings for protein separations

        2013

      • Decreased aperture surface energy enhances electrical, mechanical, and temporal stability of suspended lipid membranes

        2013

      • Photolithographic fabrication of microapertures with well-defined, three-dimensional geometries for suspended lipid membrane studies

        2013

      • Evidence for Ca su2+ su-regulated ATP release in gastrointestinal stromal tumors

        2013

      • Online photolytic optical gating of caged fluorophores in capillary zone electrophoresis utilizing an ultraviolet light-emitting diode

        2012

      • Composite nanoparticles: The best of two worlds

        2012

      • Determination of pore sizes and relative porosity in porous nanoshell architectures using dextran retention with single monomer resolution and proton permeation

        2012

      • Polymerized planar suspended lipid bilayers for single ion channel recordings: Comparison of several dienoyl lipids

        2011

      • Analysis of protein kinase A activity in insulin-secreting cells using a cell-penetrating protein substrate and capillary electrophoresis

        2010

      • Fractional polymerization of a suspended planar bilayer creates a fluid, highly stable membrane for ion channel recordings

        2010

      • Enhanced long-term stability for single ion channel recordings using suspended poly(lipid) bilayers

        2009

      • Polymer-stabilized phospholipid vesicles with a controllable, pH-dependent disassembly mechanism

        2009

      • Fabrication and characterization of spatially defined, multiple component, chemically functionalized domains in enclosed silica channels using cross-linked phospholipid membranes

        2007

      • Single residue K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: Indications for a long-chain acyl-CoA ester binding motif

        2007

      • Preparation and characterization of cross-linked phospholipid bilayer capillary coatings for protein separations

        2007

      • Design, characterization, and utilization of a fast fluorescence derivatization reaction utilizing o-phthaldialdehyde coupled with fluorescent thiols

        2007

      • Preparation and characterization of poly(lipid)coated, fluorophore-doped silica nanoparticles for biolabeling and cellular imaging

        2007

      • High-sensitivity detection of biological amines using fast Hadamard transform CE coupled with photolytic optical gating

        2007

      • High-speed capillary zone electrophoresis with online photolytic optical injection

        2006

      • Nanometre-sized molecular oxygen sensors prepared from polymer stabilized phospholipid vesicles

        2006

      • Stabilized porous phospholipid nanoshells

        2006

      • Emerging investigators special issue

        2006

      • Capillary electrophoresis with a UV light-emitting diode source for chemical monitoring of native and derivatized fluorescent compounds

        2006

      • Fast Hadamard transform capillary electrophoresis for on-line, time-resolved chemical monitoring

        2006

      • In situ fabrication of three-dimensional chemical patterns in fused silica separation capillaries with polymerized phospholipids

        2005

      • Screening populations of individual cells for secretory heterogeneity

        2005

      • Long-Chain CoA esters activate human pancreatic beta-cell KATP channels: Potential role in Type 2 diabetes

        2004

      • Removal of Ca su2+ su channel β sub 3 sub subunit enhances Ca su2+ su oscillation frequency and insulin exocytosis

        2004

      • Detection of secretion from single pancreatic β-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy

        2000

      • Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca su2+ su stores in insulin-stimulated insulin secretion in β-cells

        2000

      • Oxygen microsensor and its application to single cells and mouse pancreatic islets

        1999

      • Secretion from islets and single islet cells following cryopreservation

        1999

      • Detection of multiple patterns of oscillatory oxygen consumption in single mouse islets of Langerhans

        1999

      • Insulin-stimulated insulin secretion in single pancreatic beta cells

        1999

      • On-line competitive immunoassay based on capillary electrophoresis applied to monitoring insulin secretion from single islets of Langerhans

        1998

      • Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques

        1998

      • Ruthenium catalyst for amperometric determination of insulin at physiological pH

        1997

      • Dual microcolumn immunoassay applied to determination of insulin secretion from single islets of Langerhans and insulin in serum

        1997

      • Effects of intravesicular H su+ su and extracellular H su+ su and Zn su2+ su on insulin secretion in pancreatic beta cells

        1997

      • Extracellular pH is required for rapid release of insulin from Zn insulin precipitates in β-cell secretory vesicles during exocytosis

        1996

      • Asymmetric electrode kinetics induced by concurrent metal-ligand bond dissociation

        1993

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