KMap

Craig Aspinwall

Department Head,

Professor, Biomedical Engineering,

Member of the Graduate Faculty,

Professor, Chemistry and Biochemistry - Med,

Professor, Chemistry and Biochemistry-Sci,

Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
aspinwal@arizona.edu

520/621-6338

Grant: $7.9M

Craig Aspinwall experts in biomaterials, tissue engineering, drug delivery, regenerative medicine, diabetes, analytical chemistry, pharmacology, biosensors, ion channels, insulin secretion, microfluidics, polymer chemistry, mass spectrometry, pancreatic cancer, exocytosis, materials science, biomedical engineering, proteomics, biophysics, membranes, nanomaterials, biochemistry, molecular biology, chemistry, catalysis, biomechanics, immunology, bioengineering, cryopreservation, insulin resistance, bioinorganic chemistry, physiology, calcium signaling, bioinformatics, computational biology, biomedical informatics, spectroscopy, fluorescence microscopy, biomedical optics, medicinal chemistry, single molecule biophysics, electrophoresis, photocatalysis, cancer biology, lipids, toxicology, scanning probe microscopy, membrane proteins, phospholipid membranes, environmental engineering, environmental nanotechnology, cell biology, nanomedicine, mems, pharmaceutics

Courses

Bioanalytical Chemistry

Instrumental Analysis

Advanced Analytical Chemistry Laboratory

Analytical Separations

Analytical Chemistry

Recent Grants

	2020	$600.0K	Active
Label Free, Biomimetic Sensors for Hormones and Neurotransmitters
	2020	$50.0K	Active
I-Corps: Scintillating Nanoparticles for Low Energy Radioisotope Analytical Workflows
	2018	$360.0K
Core-Shell Nanoparticles for Direct Detection of Radioisotopes in Aqueous Environments
	2016	$174.2K
Bio/Chemical Mapping of Pancreatic Cell Activity
	2015	$1.2M
Nanoshell Sensors For Cellular Analysis
	2014	$388.3K
Hybrid nanomaterials for dynamic, intracellular radioisotope detection
	2012	$1.6M
Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes
	2011	$1.1M
Stabilized Biomimetic Separation Media
	2006	$1.9M
Ion Channel/Membrane Arrays on Electroactive Waveguides for Biomolecular Assays
	2006	$548.1K
Career: Cross-Linked Phospholipid Nanosensors for Intracellular Investigations

Technologies / Patents

	2022	Surface-Modified Interfaces Of Pneumatic Valves With Enhanced Electrical Properties
	2021	Rapid Conductance Based Ion Channel Analysis
	2020	Systems and Methods of Preparing Stabilized Lipid Assemblies
	1899	Systems and Methods of Preparing Stabilized Lipid Assemblies
	1899	Stabilized Vesicle-Functionalized Microparticles for Chemical Separations and Rapid Formation of Polymer Frits in Silica Capillaries Using Spatially-Defined Thermal Polymerization

News

2019	UA Sets Record With 284 Inventions Disclosed in FY 2019
2019	Developing a High-Resolution Picture of Disease Biology
2010	Four UA Students Named Goldwater Scholars
2004	Spying on a Cell - New Nanosensors a Body Can Live With
2003	UA Chemist Probes Cells for Causes of Diabetes

Publications (67)

Recent

2023	Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs
2022	Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry
2022	Quantification of intracellular HNO delivery with capillary zone electrophoresis
2021	Nanomechanical properties of artificial lipid bilayers composed of fluid and polymerizable lipids
2021	Direct interaction of the ATP-sensitive K+ channel by the tyrosine kinase inhibitors imatinib, sunitinib and nilotinib
2019	Hybrid Nanoparticle Platform for Nanoscale Scintillation Proximity Assay
2019	Nanodomain Formation in Planar Supported Lipid Bilayers Composed of Fluid and Polymerized Dienoyl Lipids
2019	Surface Modification of Glass/PDMS Microfluidic Valve Assemblies Enhances Valve Electrical Resistance
2018	Polystyrene-Core, Silica-Shell Scintillant Nanoparticles for Low-Energy Radionuclide Quantification in Aqueous Media
2018	Rapid formation of polymer frits in fused silica capillaries using spatially defined thermal free-radical initiated polymerization
2018	Expression, purification, and electrophysiological characterization of a recombinant, fluorescent Kir6.2 in mammalian cells
2018	Enhanced Fluorescent Protein Activity in Polymer Scaffold-Stabilized Phospholipid Nanoshells Using Neutral Redox Initiator Polymerization Conditions
2017	Enhanced Temporal Resolution with Ion Channel-Functionalized Sensors Using a Conductance-Based Measurement Protocol
2015	Methacrylate Polymer Scaffolding Enhances the Stability of Suspended Lipid Bilayers for Ion Channel Recordings and Biosensor Development
2015	Aptamer-functionalized porous phospholipid nanoshells for direct measurement of Hg(2+) in urine
2015	Highly stabilized, polymer-lipid membranes prepared on silica microparticles as stationary phases for capillary chromatography
2015	Fate of fluorescent core-shell silica nanoparticles during simulated secondary wastewater treatment
2015	Emerging trends in precision fabrication of microapertures to support suspended lipid membranes for sensors, sequencing, and beyond
2014	Hybrid phospholipid bilayer coatings for separations of cationic proteins in capillary zone electrophoresis
2014	Stabilized phospholipid membranes in chromatography: toward membrane protein-functionalized stationary phases
2014	Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent
2014	Ion channel probes for scanning ion conductance microscopy
2014	Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors
2013	Evidence for Ca sup 2+ /sup -regulated ATP release in gastrointestinal stromal tumors
2013	Decreased aperture surface energy enhances electrical, mechanical, and temporal stability of suspended lipid membranes
2013	Practical considerations for preparing polymerized phospholipid bilayer capillary coatings for protein separations
2013	Evidence for Ca2+-regulated ATP release in gastrointestinal stromal tumors
2013	Photolithographic fabrication of microapertures with well-defined, three-dimensional geometries for suspended lipid membrane studies
2012	Determination of pore sizes and relative porosity in porous nanoshell architectures using dextran retention with single monomer resolution and proton permeation
2012	Online photolytic optical gating of caged fluorophores in capillary zone electrophoresis utilizing an ultraviolet light-emitting diode
2012	Composite nanoparticles: the best of two worlds
2011	Polymerized planar suspended lipid bilayers for single ion channel recordings: comparison of several dienoyl lipids
2010	Analysis of protein kinase A activity in insulin-secreting cells using a cell-penetrating protein substrate and capillary electrophoresis
2010	Fractional polymerization of a suspended planar bilayer creates a fluid, highly stable membrane for ion channel recordings
2009	Polymer-stabilized phospholipid vesicles with a controllable, pH-dependent disassembly mechanism
2009	Enhanced long-term stability for single ion channel recordings using suspended poly(lipid) bilayers
2007	Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: Indications for a long-chain acyl-CoA ester binding motif
2007	High-sensitivity detection of biological amines using fast Hadamard transform CE coupled with photolytic optical gating
2007	Design, characterization, and utilization of a fast fluorescence derivatization reaction utilizing o-phthaldialdehyde coupled with fluorescent thiols
2007	Fabrication and characterization of spatially defined, multiple component, chemically functionalized domains in enclosed silica channels using cross-linked phospholipid membranes
2007	Preparation and characterization of poly(lipid)-coated, fluorophore-doped silica nanoparticles for biolabeling and cellular imaging
2007	Preparation and characterization of cross-linked phospholipid bilayer capillary coatings for protein separations
2006	High-speed capillary zone electrophoresis with online photolytic optical injection
2006	Emerging investigators special issue
2006	Nanometre-sized molecular oxygen sensors prepared from polymer stabilized phospholipid vesicles
2006	Stabilized porous phospholipid nanoshells
2006	Fast Hadamard transform capillary electrophoresis for on-line, time-resolved chemical monitoring
2006	Capillary electrophoresis with a UV light-emitting diode source for chemical monitoring of native and derivatized fluorescent compounds
2005	In situ fabrication of three-dimensional chemical patterns in fused silica separation capillaries with polymerized phospholipids
2005	Screening populations of individual cells for secretory heterogeneity
2004	Removal of Ca2+ channel β3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis
2004	Long-Chain CoA esters activate human pancreatic beta-cell KATP channels: Potential role in Type 2 diabetes
2004	Removal of Ca sup 2+ /sup channel β sub 3 /sub subunit enhances Ca sup 2+ /sup oscillation frequency and insulin exocytosis
2000	Detection of secretion from single pancreatic β-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy
2000	Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca sup 2+ /sup stores in insulin-stimulated insulin secretion in β-cells
1999	Detection of multiple patterns of oscillatory oxygen consumption in single mouse islets of Langerhans
1999	Insulin-stimulated insulin secretion in single pancreatic beta cells
1999	Oxygen microsensor and its application to single cells and mouse pancreatic islets
1999	Secretion from islets and single islet cells following cryopreservation
1998	Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques
1998	On-line competitive immunoassay based on capillary electrophoresis applied to monitoring insulin secretion from single islets of Langerhans
1997	Ruthenium catalyst for amperometric determination of insulin at physiological pH
1997	Dual microcolumn immunoassay applied to determination of insulin secretion from single islets of Langerhans and insulin in serum
1997	Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells
1997	Effects of intravesicular H sup + /sup and extracellular H sup + /sup and Zn sup 2+ /sup on insulin secretion in pancreatic beta cells
1996	Extracellular pH is required for rapid release of insulin from Zn - insulin precipitates in β-cell secretory vesicles during exocytosis
1993	Asymmetric electrode kinetics induced by concurrent metal-ligand bond dissociation

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