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Photo of Craig Aspinwall(aspinwal)

Craig Aspinwall

Department Head,
Professor, Biomedical Engineering,
Member of the Graduate Faculty,
Professor, Chemistry and Biochemistry - Med,
Professor, Chemistry and Biochemistry-Sci,
Professor, BIO5 Institute,

Chemistry & Biochemistry - Sci
aspinwal@arizona.edu
520/621-6338
UAVitae logogoogle scholar logoOrcid logo
Grant: $7.9M
Craig Aspinwall experts in biomaterials, tissue engineering, drug delivery, regenerative medicine, diabetes, analytical chemistry, pharmacology, biosensors, ion channels, insulin secretion, microfluidics, polymer chemistry, mass spectrometry, pancreatic cancer, exocytosis, materials science, biomedical engineering, proteomics, biophysics, membranes, nanomaterials, biochemistry, molecular biology, chemistry, catalysis, biomechanics, immunology, bioengineering, cryopreservation, insulin resistance, bioinorganic chemistry, physiology, calcium signaling, bioinformatics, computational biology, biomedical informatics, spectroscopy, fluorescence microscopy, biomedical optics, medicinal chemistry, single molecule biophysics, electrophoresis, photocatalysis, cancer biology, lipids, toxicology, scanning probe microscopy, membrane proteins, phospholipid membranes, environmental engineering, environmental nanotechnology, cell biology, nanomedicine, mems, pharmaceutics
Courses
Bioanalytical Chemistry 
Instrumental Analysis 
Advanced Analytical Chemistry Laboratory 
Analytical Separations 
Analytical Chemistry 
Recent Grants
Logo of Label Free, Biomimetic Sensors for Hormones and Neurotransmitters funding agency
2020 $600.0KActive
Label Free, Biomimetic Sensors for Hormones and Neurotransmitters
Logo of I-Corps: Scintillating Nanoparticles for Low Energy Radioisotope Analytical Workflows funding agency
2020 $50.0KActive
I-Corps: Scintillating Nanoparticles for Low Energy Radioisotope Analytical Workflows
Logo of Core-Shell Nanoparticles for Direct Detection of Radioisotopes in Aqueous Environments funding agency
2018 $360.0K
Core-Shell Nanoparticles for Direct Detection of Radioisotopes in Aqueous Environments
Logo of Bio/Chemical Mapping of Pancreatic Cell Activity funding agency
2016 $174.2K
Bio/Chemical Mapping of Pancreatic Cell Activity
Logo of Nanoshell Sensors For Cellular Analysis funding agency
2015 $1.2M
Nanoshell Sensors For Cellular Analysis
Logo of Hybrid nanomaterials for dynamic, intracellular radioisotope detection funding agency
2014 $388.3K
Hybrid nanomaterials for dynamic, intracellular radioisotope detection
Logo of Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes funding agency
2012 $1.6M
Sniffer Biosensors Based on Ion Channel-GPCR Chimeras and Polylipid Membranes
Logo of Stabilized Biomimetic Separation Media funding agency
2011 $1.1M
Stabilized Biomimetic Separation Media
Logo of Ion Channel/Membrane Arrays on Electroactive Waveguides for Biomolecular Assays funding agency
2006 $1.9M
Ion Channel/Membrane Arrays on Electroactive Waveguides for Biomolecular Assays
Logo of Career: Cross-Linked Phospholipid Nanosensors for Intracellular Investigations funding agency
2006 $548.1K
Career: Cross-Linked Phospholipid Nanosensors for Intracellular Investigations
Technologies / Patents
Logo of Surface-Modified Interfaces Of Pneumatic Valves With Enhanced Electrical Properties
2022Surface-Modified Interfaces Of Pneumatic Valves With Enhanced Electrical Properties 
Logo of Rapid Conductance Based Ion Channel Analysis
2021Rapid Conductance Based Ion Channel Analysis 
Logo of Systems and Methods of Preparing Stabilized Lipid Assemblies
2020Systems and Methods of Preparing Stabilized Lipid Assemblies 
Logo of Systems and Methods of Preparing Stabilized Lipid Assemblies
1899Systems and Methods of Preparing Stabilized Lipid Assemblies 
Logo of Stabilized Vesicle-Functionalized Microparticles for Chemical Separations and Rapid Formation of Polymer Frits in Silica Capillaries Using Spatially-Defined Thermal Polymerization
1899Stabilized Vesicle-Functionalized Microparticles for Chemical Separations and Rapid Formation of Polymer Frits in Silica Capillaries Using Spatially-Defined Thermal Polymerization 
News
2019UA Sets Record With 284 Inventions Disclosed in FY 2019 
2019Developing a High-Resolution Picture of Disease Biology 
2010Four UA Students Named Goldwater Scholars 
2004Spying on a Cell - New Nanosensors a Body Can Live With 
2003UA Chemist Probes Cells for Causes of Diabetes 
Publications (67)
Recent
2023Investigating Daptomycin–Membrane Interactions Using Native MS and Fast Photochemical Oxidation of Peptides in Nanodiscs 
2022Surface Modified Nano-Electrospray Needles Improve Sensitivity for Native Mass Spectrometry 
2022Quantification of intracellular HNO delivery with capillary zone electrophoresis 
2021Nanomechanical properties of artificial lipid bilayers composed of fluid and polymerizable lipids 
2021Direct interaction of the ATP-sensitive K+ channel by the tyrosine kinase inhibitors imatinib, sunitinib and nilotinib 
2019Hybrid Nanoparticle Platform for Nanoscale Scintillation Proximity Assay 
2019Nanodomain Formation in Planar Supported Lipid Bilayers Composed of Fluid and Polymerized Dienoyl Lipids 
2019Surface Modification of Glass/PDMS Microfluidic Valve Assemblies Enhances Valve Electrical Resistance 
2018Polystyrene-Core, Silica-Shell Scintillant Nanoparticles for Low-Energy Radionuclide Quantification in Aqueous Media 
2018Rapid formation of polymer frits in fused silica capillaries using spatially defined thermal free-radical initiated polymerization 
2018Expression, purification, and electrophysiological characterization of a recombinant, fluorescent Kir6.2 in mammalian cells 
2018Enhanced Fluorescent Protein Activity in Polymer Scaffold-Stabilized Phospholipid Nanoshells Using Neutral Redox Initiator Polymerization Conditions 
2017Enhanced Temporal Resolution with Ion Channel-Functionalized Sensors Using a Conductance-Based Measurement Protocol 
2015Methacrylate Polymer Scaffolding Enhances the Stability of Suspended Lipid Bilayers for Ion Channel Recordings and Biosensor Development 
2015Aptamer-functionalized porous phospholipid nanoshells for direct measurement of Hg(2+) in urine 
2015Highly stabilized, polymer-lipid membranes prepared on silica microparticles as stationary phases for capillary chromatography 
2015Fate of fluorescent core-shell silica nanoparticles during simulated secondary wastewater treatment 
2015Emerging trends in precision fabrication of microapertures to support suspended lipid membranes for sensors, sequencing, and beyond 
2014Hybrid phospholipid bilayer coatings for separations of cationic proteins in capillary zone electrophoresis 
2014Stabilized phospholipid membranes in chromatography: toward membrane protein-functionalized stationary phases 
2014Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent 
2014Ion channel probes for scanning ion conductance microscopy 
2014Glutathione sulfinamide serves as a selective, endogenous biomarker for nitroxyl after exposure to therapeutic levels of donors 
2013Evidence for Ca sup 2+ /sup -regulated ATP release in gastrointestinal stromal tumors 
2013Decreased aperture surface energy enhances electrical, mechanical, and temporal stability of suspended lipid membranes 
2013Practical considerations for preparing polymerized phospholipid bilayer capillary coatings for protein separations 
2013Evidence for Ca2+-regulated ATP release in gastrointestinal stromal tumors 
2013Photolithographic fabrication of microapertures with well-defined, three-dimensional geometries for suspended lipid membrane studies 
2012Determination of pore sizes and relative porosity in porous nanoshell architectures using dextran retention with single monomer resolution and proton permeation 
2012Online photolytic optical gating of caged fluorophores in capillary zone electrophoresis utilizing an ultraviolet light-emitting diode 
2012Composite nanoparticles: the best of two worlds 
2011Polymerized planar suspended lipid bilayers for single ion channel recordings: comparison of several dienoyl lipids 
2010Analysis of protein kinase A activity in insulin-secreting cells using a cell-penetrating protein substrate and capillary electrophoresis 
2010Fractional polymerization of a suspended planar bilayer creates a fluid, highly stable membrane for ion channel recordings 
2009Polymer-stabilized phospholipid vesicles with a controllable, pH-dependent disassembly mechanism 
2009Enhanced long-term stability for single ion channel recordings using suspended poly(lipid) bilayers 
2007Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: Indications for a long-chain acyl-CoA ester binding motif 
2007High-sensitivity detection of biological amines using fast Hadamard transform CE coupled with photolytic optical gating 
2007Design, characterization, and utilization of a fast fluorescence derivatization reaction utilizing o-phthaldialdehyde coupled with fluorescent thiols 
2007Fabrication and characterization of spatially defined, multiple component, chemically functionalized domains in enclosed silica channels using cross-linked phospholipid membranes 
2007Preparation and characterization of poly(lipid)-coated, fluorophore-doped silica nanoparticles for biolabeling and cellular imaging 
2007Preparation and characterization of cross-linked phospholipid bilayer capillary coatings for protein separations 
2006High-speed capillary zone electrophoresis with online photolytic optical injection 
2006Emerging investigators special issue 
2006Nanometre-sized molecular oxygen sensors prepared from polymer stabilized phospholipid vesicles 
2006Stabilized porous phospholipid nanoshells 
2006Fast Hadamard transform capillary electrophoresis for on-line, time-resolved chemical monitoring 
2006Capillary electrophoresis with a UV light-emitting diode source for chemical monitoring of native and derivatized fluorescent compounds 
2005In situ fabrication of three-dimensional chemical patterns in fused silica separation capillaries with polymerized phospholipids 
2005Screening populations of individual cells for secretory heterogeneity 
2004Removal of Ca2+ channel β3 subunit enhances Ca2+ oscillation frequency and insulin exocytosis 
2004Long-Chain CoA esters activate human pancreatic beta-cell KATP channels: Potential role in Type 2 diabetes 
2004Removal of Ca sup 2+ /sup channel β sub 3 /sub subunit enhances Ca sup 2+ /sup oscillation frequency and insulin exocytosis 
2000Detection of secretion from single pancreatic β-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy 
2000Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca sup 2+ /sup stores in insulin-stimulated insulin secretion in β-cells 
1999Detection of multiple patterns of oscillatory oxygen consumption in single mouse islets of Langerhans 
1999Insulin-stimulated insulin secretion in single pancreatic beta cells 
1999Oxygen microsensor and its application to single cells and mouse pancreatic islets 
1999Secretion from islets and single islet cells following cryopreservation 
1998Effect of cryopreservation on canine islet insulin secretion as measured by amperometric techniques 
1998On-line competitive immunoassay based on capillary electrophoresis applied to monitoring insulin secretion from single islets of Langerhans 
1997Ruthenium catalyst for amperometric determination of insulin at physiological pH 
1997Dual microcolumn immunoassay applied to determination of insulin secretion from single islets of Langerhans and insulin in serum 
1997Effects of intravesicular H+ and extracellular H+ and Zn2+ on insulin secretion in pancreatic beta cells 
1997Effects of intravesicular H sup + /sup and extracellular H sup + /sup and Zn sup 2+ /sup on insulin secretion in pancreatic beta cells 
1996Extracellular pH is required for rapid release of insulin from Zn - insulin precipitates in β-cell secretory vesicles during exocytosis 
1993Asymmetric electrode kinetics induced by concurrent metal-ligand bond dissociation 
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