Dr. Vedantham’s research interests are in the design, development and clinical translation of novel x-ray imaging systems and imaging techniques with particular focus on oncological and interventional imaging. He along with his collaborators and colleagues had made major contributions to breast cancer imaging including small-field digital mammography for stereotactic core-biopsies, full-field digital mammography and digital breast tomosynthesis. Currently, he is working on developing advanced tomographic techniques and systems for breast imaging and its clinical translation. This design, development and clinical translation oriented research is funded by the National Institutes of Health. He is also conducting research in interventional imaging with a focus on the development of advanced detector technology.