The University of Arizona
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Suwon Kim

Member of the Graduate Faculty | Associate Professor, Genetics - GIDP | Associate Professor, Cancer Biology - GIDP | Associate Professor, Basic Medical Sciences | Associate Professor, Clinical Translational Sciences

College of Medicine - Phoenix
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9+ Collaborators
$1.1M / $1.2M Funding
30+ Publications

About

We investigate tumor suppressor TS) genes in cancer and how TS deficiencies lead to tumor formation and progression. We have characterized Inhibitor of Growth 4 ING4) TS in breast cancer, of which deficiency is correlated with metastatic and therapy-resistant tumors. We have defined ING4 as a transcriptional regulator that plays a critical role in tumor-immune modulation and hormone response. Ongoing studies include the molecular mechanism of ING4 and TSs in neuroblastoma and lung cancer.

Research Area

breast cancer, cancer, genetics, tumor suppressor, gene expression, tumorigenesis, immunology, patient survival, ing4, cell migration

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    Recent

    Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer

    2024
    metastatic progression, immune response, cancer metastasis

    Cxcl10 chemokine induces migration of ING4-deficient breast cancer cells via a novel crosstalk mechanism between the Cxcr3 and Egfr receptors

    2022
    breast cancer, chemokine, cell migration, crosstalk mechanism, receptor interaction

    Abstract 2426: GNG4 is a candidate G-protein gamma;subunit downstream of the Cxcl10/Cxcr3 axis that mediates cell migration in breast cancer

    2022
    cancer, cell migration, g-protein signaling, gene expression, immunology

    Abstract 1978: ING4 deficiency results in recurrent crosstalk between Cxcl10/Cxcr3 and Egfr in breast cancer cells

    2021
    breast cancer, genetics, cell signaling, cancer biology, tumor suppressor

    Single-Cell RNA Sequencing of a Postmenopausal Normal Breast Tissue Identifies Multiple Cell Types That Contribute to Breast Cancer

    2020
    breast cancer, rna sequencing, cell types, postmenopausal, normal breast tissue

    Abstract 3412: Genomic signature of trastuzumab neoadjuvant therapy predictive of patient survival in HER2-positive breast cancer

    2019
    genomic signature, neoadjuvant therapy, predictive biomarkers, patient survival, her2-positive breast cancer

    Abstract 3425: Mutations in DNA repair and microtubule assembly genes found in triple negative breast tumors treated with neoadjuvant chemotherapy

    2019
    breast cancer, dna repair, chemotherapy, gene mutations, tumor treatment

    Abstract 3453: CXCL10 contributes to aggressive disease progression in ING4-deficient breast cancer

    2019
    breast cancer, disease progression, cxcl10, ing4, aggressive

    PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer

    2019
    breast cancer, pd-1, gene expression, neoadjuvant treatment, patient survival

    Tumor suppressor insufficiency: What’s in an expression?

    2018
    cancer, gene expression, tumor biology, cellular pathways, genetics

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    • Cellular, Molecular and Neural Biology

    • Thesis

    • Individualized Scientific Writing

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