Unresectable refers to a medical condition or situation where a tumor or abnormal growth cannot be completely removed through surgery. This term is often used in the context of cancer treatment, where some tumors are located in difficult-to-reach areas or have spread to nearby tissues, making complete surgical removal impossible. In the field of oncology, researchers and clinicians work to develop alternative treatment options for patients with unresectable tumors, such as radiation therapy, chemotherapy, targeted therapy, immunotherapy, and other novel approaches. The goal of these treatments is to shrink the tumor, alleviate symptoms, and improve the patient's quality of life. Research in the area of unresectable tumors focuses on developing more effective and personalized treatment strategies, as well as improving early detection methods to identify these tumors at an earlier stage when they may still be resectable. Additionally, researchers may also be interested in studying the underlying mechanisms of tumor growth and resistance to treatment in unresectable tumors to identify new therapeutic targets and improve patient outcomes.