Metalloproteinases are a group of enzymes that play a crucial role in various biological processes, such as tissue remodeling, wound healing, cell migration, and inflammation. These enzymes are responsible for breaking down proteins in the extracellular matrix and have been implicated in various diseases, including cancer, arthritis, and cardiovascular diseases. Metalloproteinases require metal ions, usually zinc, in their active site to function properly. There are several families of metalloproteinases, including matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM), and A Disintegrin and Metalloproteinase with Thrombosponin motifs (ADAMTS). Research in the field of metalloproteinases focuses on understanding their structure, function, regulation, and role in various diseases. Scientists are also exploring the potential of metalloproteinases as therapeutic targets for the treatment of diseases, as well as the development of inhibitors to modulate their activity.