HIF2α, or hypoxia-inducible factor 2 alpha, is a transcription factor that plays a critical role in response to low oxygen levels in the cellular environment, a condition known as hypoxia. HIF2α is part of the HIF family of proteins, which regulate the expression of genes involved in various cellular processes, including metabolism, angiogenesis, and cell proliferation. Research on HIF2α has focused on understanding its role in cancer, as tumors often experience low oxygen levels due to poor blood supply and rapid growth. Studies have shown that HIF2α can promote tumor growth and metastasis by regulating the expression of genes involved in angiogenesis and metastasis. Targeting HIF2α is being explored as a potential therapeutic strategy for inhibiting tumor growth and improving the efficacy of cancer treatments. In addition to cancer, HIF2α has also been implicated in other diseases and conditions, such as pulmonary hypertension, ischemic heart disease, and kidney disease. Further research on HIF2α may lead to the development of novel therapies for a variety of hypoxia-related disorders.