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I am a Physics Professor at the Univ. of Arizona, holding joint appointments in the Dept. of Mol. and Cell. Biology, and the College of Optical Sciences. I am also a member of the Biological Physics Program, Chemical Physics Program, and Biological Chemistry Program, and an affiliated member of Applied Mathematics. I received my PhD in 1993 from the University of Amsterdam in The Netherlands.
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Courses
  • HIM
    Honors Introductory Mechanics

  • IOT
    Introductory Optics and Thermodynamics

  • EIS
    Explorations in Integrated Science

  • HIOT
    Honors Introductory Optics and Thermodynamics

  • IM
    Introductory Mechanics

  • TP
    Thermal Physics

  • SM
    Statistical Mechanics

  • MTP
    Mathematical Techniques in Physics

  • O
    Optics

  • TSGC
    The Science of Good Cooking

  • MB
    Molecular Biophysics

  • MP
    Medical Physics

Grants
  • Funding agency logo
    Undergraduate Scholarships in Integrated Science

    Co-Investigator (COI)

    2006

    $500.0K
News
  • Want to Silence a Gene? Pull Here.

    2011

  • Four UA Students Named Goldwater Scholars

    2010

Publications (46)
Recent
  • -1 Programmed Ribosomal Frameshifting as a Force-Dependent Process

    2016

  • A stochastic model of translation with -1 programmed ribosomal frameshifting

    2014

  • Proposal of a new imaging method with trapped gold nano particles and the properties of multi-photon emission

    2014

  • Cation Binding and Screening Effects on Single-Stranded Helix Formation in Poly(A) RNA

    2012

  • Mechanical unfolding of the beet western yellow virus -1 frameshift signal

    2011

  • Optical trapping and unfolding of RNA

    2011

  • Mechanical unfolding of the Beet Western Yellow Virus - 1 frameshift signal

    2011

  • Stretching Poly(A) to Investigate Elastic Behavior at Low Ionic Strength

    2011

  • Downstream DNA tension regulates the stability of the T7 RNA polymerase initiation complex

    2011

  • Simultaneous calibration of optical tweezers spring constant and position detector response

    2010

  • Simulated and Mechanical Unfolding of the Beet Western Yellow Virus −1 Frameshift Signal

    2010

  • Identifying and quantifying load-dependence in transcription initiation by T7 RNA Polymerase

    2009

  • Optical force model based on sequential ray tracing

    2009

  • A method for quantifying the force dependence of initiation by T7 RNA polymerase

    2009

  • Interaction of the HIV-1 frameshift signal with the ribosome

    2009

  • Phase measurements of barrier crossings in a periodically modulated double-well potential

    2009

  • Footprinting analysis of BWYV pseudoknot-ribosome complexes

    2009

  • An objective, model-independent method for detection of non-uniform steps in noisy signals

    2008

  • Translation Against An Applied Force.

    2008

  • Inferring kinetic pathways, rates, and force dependence from nonprocessive optical tweezers experiments: a maximum likelihood approach

    2008

  • Translation against an applied force

    2007

  • Biocompatible Writing of Data into DNA

    2007

  • A rapid, objective method for detection of non-uniform steps in noisy signals.

    2007

  • Stretching of homopolymeric RNA reveals single-stranded helices and base-stacking

    2007

  • Suppression of noise in a noisy optical trap

    2004

  • Elastic properties of a single-stranded charged homopolymeric ribonucleotide

    2004

  • Noise suppression and spectral decomposition for state-dependent noise in the presence of a stationary fluctuating input

    2004

  • Single-molecule techniques for drug discovery

    2004

  • Colloidal epitaxy: Playing with the boundary conditions of colloidal crystallization

    2003

  • Force production by single kinesin motors

    2000

  • Single kinesin molecules studied with a molecular force clamp

    1999

  • [38] Versatile optical traps with feedback control

    1998

  • Construction of multiple-beam optical traps with nanometer-resolution position sensing

    1996

  • New method for fluorescence lifetime imaging in bilateral-confocal microscopy by double-pulse excitation

    1995

  • Double-pulse fluorescence lifetime imaging in confocal microscopy

    1995

  • Real-time confocal microscopy

    1994

  • Fluorescence bleach rate imaging

    1994

  • Fluorescence saturation in confocal microscopy

    1994

  • Micromanipulation by 'multiple' optical traps created by a single fast scanning trap integrated with the bilateral confocal scanning laser microscope

    1993

  • Isolation of single yeast cells by optical trapping

    1993

  • Imaging modes for bilateral confocal scanning microscopy

    1993

  • High-sensitivity confocal imaging with bilateral scanning and CCD detectors

    1992

  • Confocal microscopy for the life sciences

    1992

  • Single beam optical trapping integrated in a confocal microscope for biological applications

    1991

  • Confocal imaging with bilateral scanning and array detectors

    1991

  • Confocal microscopy for the biological and material sciences: principle, applications, limitations

    1991

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